Endocannabinoid tone in the nervous system: molecular mechanisms & dependencies

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

Human evidence only

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

Where it participates (unsigned role)

Fatty acid amide hydrolase is the principal enzyme hydrolysing fatty acid amides including anandamide, terminating their signalling.
Fatty acid amide hydrolase / FAAH → Anandamide / arachidonylethanolamide source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/thc-research/15952893.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3213ef73e4fe6ef00bd2a0f1c09319ebc1e000f9cfd200ce3c1852f1e045c62c", "start_char": 0, "end_char": 724, "text_sha256": "3213ef73e4fe6ef00bd2a0f1c09319ebc1e000f9cfd200ce3c1852f1e045c62c"}
experimental_model
Review of fatty acid amide hydrolase structure and function
exposure
Hydrolysis of fatty acid amides including anandamide
limitations
A review, labelled as such, used for the enzymology. The structural claim is recorded from the crystal structure paper separately.
nutrient_topic
THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
organism
Mammalian enzyme
plain_language
One enzyme destroys the natural ligand within seconds of it being made.
primary_references
[thc-p15952893] Structure and function of fatty acid amide hydrolase. (2005). https://pubmed.ncbi.nlm.nih.gov/15952893/ DOI: 10.1146/annurev.biochem.74.082803.133450
tissue_or_cell_type
Membrane-bound enzyme
THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 361–372
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Review of fatty acid amide hydrolase structure and function · source_derived_draft · unverified_draft
### thc-faah-degrades-anandamide Fatty acid amide hydrolase is the principal enzyme hydrolysing fatty acid amides including anandamide, terminating their signalling. Condition category: normal nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: One enzyme destroys the natural ligand within seconds of it being made. organism: Mammalian enzyme tissue_or_cell_type: Membrane-bound enzyme experimental_model: Review of fatty acid amide hydrolase structure and function limitations: A review, labelled as such, used for the enzymology. The structural claim is recorded from the crystal structure paper separately. exposure: Hydrolysis of fatty acid amides including anandamide evidence_span: {"source_cache": "artifacts/thc-research/15952893.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3213ef73e4fe6ef00bd2a0f1c09319ebc1e000f9cfd200ce3c1852f1e045c62c", "start_char": 0, "end_char": 724, "text_sha256": "3213ef73e4fe6ef00bd2a0f1c09319ebc1e000f9cfd200ce3c1852f1e045c62c"} [thc-p15952893] Structure and function of fatty acid amide hydrolase. (2005). https://pubmed.ncbi.nlm.nih.gov/15952893/ DOI: 10.1146/annurev.biochem.74.082803.133450
Complete structured claim and evidence
Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system.
Monoacylglycerol lipase / MGLL → 2-Arachidonoylglycerol / 2-AG source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/thc-research/20855465.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ab326436e1ae7e9672e4170f62162a4ec30278a2a2380fd9c1cc64f1a88d0bf8", "start_char": 0, "end_char": 1490, "text_sha256": "ab326436e1ae7e9672e4170f62162a4ec30278a2a2380fd9c1cc64f1a88d0bf8"}
experimental_model
Monoacylglycerol lipase manipulation with endocannabinoid measurement
exposure
MAGL inhibition and genetic disruption
limitations
Establishes the enzyme as the tone-setting step for the other endocannabinoid.
nutrient_topic
THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
organism
Mouse
plain_language
A second enzyme controls how much of the other messenger is around at rest.
primary_references
[thc-p20855465] Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system. (2010). https://pubmed.ncbi.nlm.nih.gov/20855465/ DOI: 10.1124/mol.110.068304
tissue_or_cell_type
Nervous system
THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 387–398
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Monoacylglycerol lipase manipulation with endocannabinoid measurement · source_derived_draft · unverified_draft
### thc-magl-sets-tone Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system. Condition category: normal nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: A second enzyme controls how much of the other messenger is around at rest. organism: Mouse tissue_or_cell_type: Nervous system experimental_model: Monoacylglycerol lipase manipulation with endocannabinoid measurement limitations: Establishes the enzyme as the tone-setting step for the other endocannabinoid. exposure: MAGL inhibition and genetic disruption evidence_span: {"source_cache": "artifacts/thc-research/20855465.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ab326436e1ae7e9672e4170f62162a4ec30278a2a2380fd9c1cc64f1a88d0bf8", "start_char": 0, "end_char": 1490, "text_sha256": "ab326436e1ae7e9672e4170f62162a4ec30278a2a2380fd9c1cc64f1a88d0bf8"} [thc-p20855465] Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system. (2010). https://pubmed.ncbi.nlm.nih.gov/20855465/ DOI: 10.1124/mol.110.068304
Complete structured claim and evidence

The events it takes part in

A mechanism often involves more than two components. These are the full events, with every participant and its role.

Situations it appears in

Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

Open hypotheses

Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.

This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

Endocannabinoid tone in the nervous system