Component

Depolarisation-induced suppression of inhibition

Depolarisation-induced suppression of inhibition. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

Where it participates (unsigned role)

  1. Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses, travelling from the depolarised postsynaptic neuron back to the presynaptic terminal.

    2-Arachidonoylglycerol / 2-AG → Retrograde endocannabinoid signalling from postsynaptic neuron to presynaptic terminal source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/thc-research/11279497.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f93de867c0ce253b42d9c248504f4471431310bdc0629fec2a8c49d2eba55e8e", "start_char": 0, "end_char": 1117, "text_sha256": "f93de867c0ce253b42d9c248504f4471431310bdc0629fec2a8c49d2eba55e8e"}
    experimental_model
    Paired recordings in rat hippocampal slices with CB1 antagonists
    exposure
    Postsynaptic depolarisation with presynaptic release measurement
    limitations
    Establishes the direction of the signal, which is what makes the system a feedback loop rather than a transmitter pathway.
    nutrient_topic
    THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
    organism
    Rat
    plain_language
    The signal runs backwards across the synapse, which almost nothing else does.
    primary_references
    [thc-p11279497] Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses. (2001). https://pubmed.ncbi.nlm.nih.gov/11279497/ DOI: 10.1038/35069076
    tissue_or_cell_type
    Hippocampus

    THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 270–281

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Paired recordings in rat hippocampal slices with CB1 antagonists · source_derived_draft · unverified_draft

    ### thc-retrograde-hippocampus Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses, travelling from the depolarised postsynaptic neuron back to the presynaptic terminal. Condition category: normal nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: The signal runs backwards across the synapse, which almost nothing else does. organism: Rat tissue_or_cell_type: Hippocampus experimental_model: Paired recordings in rat hippocampal slices with CB1 antagonists limitations: Establishes the direction of the signal, which is what makes the system a feedback loop rather than a transmitter pathway. exposure: Postsynaptic depolarisation with presynaptic release measurement evidence_span: {"source_cache": "artifacts/thc-research/11279497.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f93de867c0ce253b42d9c248504f4471431310bdc0629fec2a8c49d2eba55e8e", "start_char": 0, "end_char": 1117, "text_sha256": "f93de867c0ce253b42d9c248504f4471431310bdc0629fec2a8c49d2eba55e8e"} [thc-p11279497] Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses. (2001). https://pubmed.ncbi.nlm.nih.gov/11279497/ DOI: 10.1038/35069076
    Complete structured claim and evidence

  2. Endogenous cannabinoids mediate retrograde signals from depolarised postsynaptic neurons to presynaptic terminals, suppressing transmitter release.

    2-Arachidonoylglycerol / 2-AG → GABA release from inhibitory terminals source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/thc-research/11301031.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e3604f96d0bb63e313cf39b0905f250a3d05ec58f88529cceda5fda4bbda8006", "start_char": 0, "end_char": 1026, "text_sha256": "e3604f96d0bb63e313cf39b0905f250a3d05ec58f88529cceda5fda4bbda8006"}
    experimental_model
    Recordings from depolarised postsynaptic neurons with presynaptic terminal measurement
    exposure
    Depolarisation-induced suppression with cannabinoid antagonists
    limitations
    An independent report of the same retrograde mechanism from a different group in the same year.
    nutrient_topic
    THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
    organism
    Rodent
    plain_language
    A second laboratory saw the same backwards signal in the same year.
    primary_references
    [thc-p11301031] Endogenous cannabinoids mediate retrograde signals from depolarized postsynaptic neurons to presynaptic terminals. (2001). https://pubmed.ncbi.nlm.nih.gov/11301031/ DOI: 10.1016/s0896-6273(01)00247-1
    tissue_or_cell_type
    Hippocampus

    THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 283–294

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Recordings from depolarised postsynaptic neurons with presynaptic terminal measurement · source_derived_draft · unverified_draft

    ### thc-retrograde-independent Endogenous cannabinoids mediate retrograde signals from depolarised postsynaptic neurons to presynaptic terminals, suppressing transmitter release. Condition category: normal nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: A second laboratory saw the same backwards signal in the same year. organism: Rodent tissue_or_cell_type: Hippocampus experimental_model: Recordings from depolarised postsynaptic neurons with presynaptic terminal measurement limitations: An independent report of the same retrograde mechanism from a different group in the same year. exposure: Depolarisation-induced suppression with cannabinoid antagonists evidence_span: {"source_cache": "artifacts/thc-research/11301031.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e3604f96d0bb63e313cf39b0905f250a3d05ec58f88529cceda5fda4bbda8006", "start_char": 0, "end_char": 1026, "text_sha256": "e3604f96d0bb63e313cf39b0905f250a3d05ec58f88529cceda5fda4bbda8006"} [thc-p11301031] Endogenous cannabinoids mediate retrograde signals from depolarized postsynaptic neurons to presynaptic terminals. (2001). https://pubmed.ncbi.nlm.nih.gov/11301031/ DOI: 10.1016/s0896-6273(01)00247-1
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards