Component

Dimethylglycine

Independently recorded entity or measured process. Linked claims specify compartment, assay and experimental scope.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Rat DMGDH catalyzes oxidative demethylation of dimethylglycine to sarcosine.

    Rat dimethylglycine dehydrogenase / Dmgdh → Dimethylglycine source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/choline-research/24858690.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e00bbb8f1c2c805e9d7261c286bace5758abd277bc95b3e0a830bd9cdb82a34f", "start_char": 0, "end_char": 1506, "text_sha256": "e00bbb8f1c2c805e9d7261c286bace5758abd277bc95b3e0a830bd9cdb82a34f"}
    experimental_model
    Rat DMGDH crystallography and enzyme characterization
    exposure
    Dimethylglycine turnover and THF-bound structures
    limitations
    Species and assay context retained. The proposed intramolecular transfer route is not represented as a directly observed moving intermediate.
    nutrient_topic
    Choline research collection; topical membership is not evidence of a direct dietary effect. · Choline
    organism
    Rat recombinant enzyme
    plain_language
    After betaine donates one methyl group, another enzyme handles the remaining dimethylglycine.
    primary_references
    [choline-p24858690] Folate in demethylation: the crystal structure of the rat dimethylglycine dehydrogenase complexed with tetrahydrofolate. (2014). https://pubmed.ncbi.nlm.nih.gov/24858690/ DOI: 10.1016/j.bbrc.2014.05.064
    tissue_or_cell_type
    Mitochondrial-enzyme preparation

    Choline: metabolism, signaling and nutrient connections (2026-09-17) · lines 659–670

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Rat DMGDH crystallography and enzyme characterization · source_derived_draft · unverified_draft

    ### choline-dmgdh-sarcosine Rat DMGDH catalyzes oxidative demethylation of dimethylglycine to sarcosine. Condition category: normal nutrient_topic: Choline research collection; topical membership is not evidence of a direct dietary effect. plain_language: After betaine donates one methyl group, another enzyme handles the remaining dimethylglycine. organism: Rat recombinant enzyme tissue_or_cell_type: Mitochondrial-enzyme preparation experimental_model: Rat DMGDH crystallography and enzyme characterization limitations: Species and assay context retained. The proposed intramolecular transfer route is not represented as a directly observed moving intermediate. exposure: Dimethylglycine turnover and THF-bound structures evidence_span: {"source_cache": "artifacts/choline-research/24858690.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e00bbb8f1c2c805e9d7261c286bace5758abd277bc95b3e0a830bd9cdb82a34f", "start_char": 0, "end_char": 1506, "text_sha256": "e00bbb8f1c2c805e9d7261c286bace5758abd277bc95b3e0a830bd9cdb82a34f"} [choline-p24858690] Folate in demethylation: the crystal structure of the rat dimethylglycine dehydrogenase complexed with tetrahydrofolate. (2014). https://pubmed.ncbi.nlm.nih.gov/24858690/ DOI: 10.1016/j.bbrc.2014.05.064
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Plasma creatine decreased 40% in both meal states; creatinine fell 9% and dimethylglycine 16% postprandially.

    Vitamin B6 → Creatine source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    nutrient_deficiency Imported condition classification; unverified.
    cross_nutrient
    Plasma metabolites connect B6 status with one-carbon metabolism without establishing a complete causal chain.
    experimental_model
    Twenty-three healthy adults; paired pre/postprandial LC-MS/MS metabolite profiling.
    exposure
    28 days below 0.35 mg/day B6. Related restriction research program; do not count paper totals as independent trial replications.
    limitations
    This does not establish exhausted SAM, impaired muscle phosphocreatine or a direct PLP requirement for creatine methylation.
    nutrient_topic
    Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin B6
    organism
    Homo sapiens
    plain_language
    B6 restriction changed selected methylation-related metabolites.
    primary_references
    [b6-dasilva2013] Metabolite profile analysis reveals functional effects of 28-day vitamin B-6 restriction on one-carbon metabolism and tryptophan catabolic pathways in healthy men and women (2013). https://pubmed.ncbi.nlm.nih.gov/23966327/ DOI: 10.3945/jn.113.180588
    tissue_or_cell_type
    Human blood and whole-body measurements
    trigger_kind
    nutrient_deficiency Imported condition classification; unverified.

    Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1423–1434

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Twenty-three healthy adults; paired pre/postprandial LC-MS/MS metabolite profiling. · source_derived_draft · unverified_draft

    ### b6-restriction-creatine-profile Plasma creatine decreased 40% in both meal states; creatinine fell 9% and dimethylglycine 16% postprandially. Condition category: nutrient_deficiency nutrient_topic: Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. plain_language: B6 restriction changed selected methylation-related metabolites. organism: Homo sapiens tissue_or_cell_type: Human blood and whole-body measurements experimental_model: Twenty-three healthy adults; paired pre/postprandial LC-MS/MS metabolite profiling. limitations: This does not establish exhausted SAM, impaired muscle phosphocreatine or a direct PLP requirement for creatine methylation. exposure: 28 days below 0.35 mg/day B6. Related restriction research program; do not count paper totals as independent trial replications. cross_nutrient: Plasma metabolites connect B6 status with one-carbon metabolism without establishing a complete causal chain. [b6-dasilva2013] Metabolite profile analysis reveals functional effects of 28-day vitamin B-6 restriction on one-carbon metabolism and tryptophan catabolic pathways in healthy men and women (2013). https://pubmed.ncbi.nlm.nih.gov/23966327/ DOI: 10.3945/jn.113.180588
    Complete structured claim and evidence

  2. In the THF-coupled DMGDH pathway, a removed one-carbon unit is captured as 5,10-methylenetetrahydrofolate rather than released as free formaldehyde.

    Tetrahydrofolate → 5,10-Methylenetetrahydrofolate source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/choline-research/24858690.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e00bbb8f1c2c805e9d7261c286bace5758abd277bc95b3e0a830bd9cdb82a34f", "start_char": 0, "end_char": 1506, "text_sha256": "e00bbb8f1c2c805e9d7261c286bace5758abd277bc95b3e0a830bd9cdb82a34f"}
    experimental_model
    Rat DMGDH crystallography and enzyme characterization
    exposure
    Dimethylglycine turnover and THF-bound structures
    limitations
    Pathway chemistry interpreted with rat enzyme structures; not proof that dietary folate rescue restores every human choline-dependent function.
    nutrient_topic
    Choline research collection; topical membership is not evidence of a direct dietary effect. · Choline
    organism
    Rat recombinant enzyme
    plain_language
    Choline-derived methyl metabolism feeds the folate pool.
    primary_references
    [choline-p24858690] Folate in demethylation: the crystal structure of the rat dimethylglycine dehydrogenase complexed with tetrahydrofolate. (2014). https://pubmed.ncbi.nlm.nih.gov/24858690/ DOI: 10.1016/j.bbrc.2014.05.064
    tissue_or_cell_type
    Mitochondrial-enzyme preparation

    Choline: metabolism, signaling and nutrient connections (2026-09-17) · lines 685–696

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Rat DMGDH crystallography and enzyme characterization · source_derived_draft · unverified_draft

    ### choline-dmgdh-one-carbon In the THF-coupled DMGDH pathway, a removed one-carbon unit is captured as 5,10-methylenetetrahydrofolate rather than released as free formaldehyde. Condition category: normal nutrient_topic: Choline research collection; topical membership is not evidence of a direct dietary effect. plain_language: Choline-derived methyl metabolism feeds the folate pool. organism: Rat recombinant enzyme tissue_or_cell_type: Mitochondrial-enzyme preparation experimental_model: Rat DMGDH crystallography and enzyme characterization limitations: Pathway chemistry interpreted with rat enzyme structures; not proof that dietary folate rescue restores every human choline-dependent function. exposure: Dimethylglycine turnover and THF-bound structures evidence_span: {"source_cache": "artifacts/choline-research/24858690.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e00bbb8f1c2c805e9d7261c286bace5758abd277bc95b3e0a830bd9cdb82a34f", "start_char": 0, "end_char": 1506, "text_sha256": "e00bbb8f1c2c805e9d7261c286bace5758abd277bc95b3e0a830bd9cdb82a34f"} [choline-p24858690] Folate in demethylation: the crystal structure of the rat dimethylglycine dehydrogenase complexed with tetrahydrofolate. (2014). https://pubmed.ncbi.nlm.nih.gov/24858690/ DOI: 10.1016/j.bbrc.2014.05.064
    Complete structured claim and evidence

  3. Purified human BHMT uses betaine and homocysteine in the alternative methionine-forming reaction.

    Betaine-homocysteine S-methyltransferase / BHMT → L-Methionine source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    Betaine/choline and folate routes meet at homocysteine.
    experimental_model
    Recombinant human BHMT and human liver-derived BHMT.
    limitations
    Does not establish complete folate substitution in vivo.
    nutrient_topic
    Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. · Folate (vitamin B9)
    organism
    Homo sapiens
    plain_language
    Betaine supplies another recycling route.
    primary_references
    [millian-1998] Human betaine-homocysteine methyltransferase is a zinc metalloenzyme (1998). https://pubmed.ncbi.nlm.nih.gov/9681996/ DOI: 10.1006/abbi.1998.0757
    tissue_or_cell_type
    Recombinant and liver-derived enzyme

    Folate and folic acid: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 610–620

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Recombinant human BHMT and human liver-derived BHMT. · source_derived_draft · unverified_draft

    ### folate-methyl-bhmt-reaction Purified human BHMT uses betaine and homocysteine in the alternative methionine-forming reaction. Condition category: normal nutrient_topic: Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: Betaine supplies another recycling route. organism: Homo sapiens tissue_or_cell_type: Recombinant and liver-derived enzyme experimental_model: Recombinant human BHMT and human liver-derived BHMT. limitations: Does not establish complete folate substitution in vivo. cross_nutrient: Betaine/choline and folate routes meet at homocysteine. [millian-1998] Human betaine-homocysteine methyltransferase is a zinc metalloenzyme (1998). https://pubmed.ncbi.nlm.nih.gov/9681996/ DOI: 10.1006/abbi.1998.0757
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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