Component

Plasma DIM exposure

Plasma DIM exposure. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Mean peak DIM concentrations were 32, 104 and 108 ng/mL after the reported 100, 200 and 300 mg doses, respectively.

    3,3'-Diindolylmethane / DIM → Plasma DIM exposure source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/dim-research/18843002.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c6685bdd57ec7598e6a1fbbbe46f4c8708e0a9a700ed19ebbbc5e35a84c3c60c", "start_char": 0, "end_char": 1513, "text_sha256": "c6685bdd57ec7598e6a1fbbbe46f4c8708e0a9a700ed19ebbbc5e35a84c3c60c"}
    experimental_model
    Single ascending-dose randomized pharmacokinetic study
    exposure
    Absorption-enhanced BR-DIM; small dose cohorts
    limitations
    Formulation-specific, small single-dose cohorts; not a universal safe dose, long-term safety threshold or clinical-efficacy study.
    nutrient_topic
    Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect. · 3,3'-Diindolylmethane / DIM
    organism
    Healthy nonsmoking drug-free adults
    plain_language
    Doubling a dose did not reliably double blood exposure.
    primary_references
    [dim-p18843002] Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjects. (2008). https://pubmed.ncbi.nlm.nih.gov/18843002/ DOI: 10.1158/1055-9965.epi-08-0520
    tissue_or_cell_type
    Plasma DIM

    Diindolylmethane (DIM): formation, receptor signaling, metabolism and drug interactions (2026-09-17) · lines 194–205

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Single ascending-dose randomized pharmacokinetic study · source_derived_draft · unverified_draft

    ### dim-dim-pk Mean peak DIM concentrations were 32, 104 and 108 ng/mL after the reported 100, 200 and 300 mg doses, respectively. Condition category: normal nutrient_topic: Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect. plain_language: Doubling a dose did not reliably double blood exposure. organism: Healthy nonsmoking drug-free adults tissue_or_cell_type: Plasma DIM experimental_model: Single ascending-dose randomized pharmacokinetic study limitations: Formulation-specific, small single-dose cohorts; not a universal safe dose, long-term safety threshold or clinical-efficacy study. exposure: Absorption-enhanced BR-DIM; small dose cohorts evidence_span: {"source_cache": "artifacts/dim-research/18843002.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c6685bdd57ec7598e6a1fbbbe46f4c8708e0a9a700ed19ebbbc5e35a84c3c60c", "start_char": 0, "end_char": 1513, "text_sha256": "c6685bdd57ec7598e6a1fbbbe46f4c8708e0a9a700ed19ebbbc5e35a84c3c60c"} [dim-p18843002] Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjects. (2008). https://pubmed.ncbi.nlm.nih.gov/18843002/ DOI: 10.1158/1055-9965.epi-08-0520
    Complete structured claim and evidence

  2. Mean DIM peak concentration rose from 61 to 607 ng/mL between 400 and 1000 mg I3C, with no further increase at 1200 mg and substantial individual variation.

    Indole-3-carbinol / I3C → Plasma DIM exposure source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/dim-research/17164373.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "610f95545a8b0fa523b17baa7798c2936b9af5bc789257b3fc98bb0aae2bc298", "start_char": 0, "end_char": 1606, "text_sha256": "610f95545a8b0fa523b17baa7798c2936b9af5bc789257b3fc98bb0aae2bc298"}
    experimental_model
    Phase I single- and repeated-dose pharmacokinetics
    exposure
    I3C single doses 400-1200 mg and repeated-dose follow-up
    limitations
    I3C intervention, not purified DIM. Assay detection limits and interindividual variation matter.
    nutrient_topic
    Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect. · 3,3'-Diindolylmethane / DIM
    organism
    Women given I3C
    plain_language
    Exposure did not continue rising proportionally as the precursor dose increased.
    primary_references
    [dim-p17164373] Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmethane. (2006). https://pubmed.ncbi.nlm.nih.gov/17164373/ DOI: 10.1158/1055-9965.epi-06-0396
    tissue_or_cell_type
    Plasma I3C and condensation products

    Diindolylmethane (DIM): formation, receptor signaling, metabolism and drug interactions (2026-09-17) · lines 181–192

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Phase I single- and repeated-dose pharmacokinetics · source_derived_draft · unverified_draft

    ### dim-i3c-pk-nonlinear Mean DIM peak concentration rose from 61 to 607 ng/mL between 400 and 1000 mg I3C, with no further increase at 1200 mg and substantial individual variation. Condition category: normal nutrient_topic: Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect. plain_language: Exposure did not continue rising proportionally as the precursor dose increased. organism: Women given I3C tissue_or_cell_type: Plasma I3C and condensation products experimental_model: Phase I single- and repeated-dose pharmacokinetics limitations: I3C intervention, not purified DIM. Assay detection limits and interindividual variation matter. exposure: I3C single doses 400-1200 mg and repeated-dose follow-up evidence_span: {"source_cache": "artifacts/dim-research/17164373.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "610f95545a8b0fa523b17baa7798c2936b9af5bc789257b3fc98bb0aae2bc298", "start_char": 0, "end_char": 1606, "text_sha256": "610f95545a8b0fa523b17baa7798c2936b9af5bc789257b3fc98bb0aae2bc298"} [dim-p17164373] Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmethane. (2006). https://pubmed.ncbi.nlm.nih.gov/17164373/ DOI: 10.1158/1055-9965.epi-06-0396
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards