{"id":"22897849-29ed-552c-947d-8459f546cd4d","stable_key":"182336c6-ed36-5ec6-8a09-25c31096262e:dim-i3c-pk-nonlinear","predicate":"dose_changes","statement":"Mean DIM peak concentration rose from 61 to 607 ng/mL between 400 and 1000 mg I3C, with no further increase at 1200 mg and substantial individual variation.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"c8e37aa7-0cbc-5ab0-945f-55947fc3fe5e","mechanism_event_label":"Exposure did not continue rising proportionally as the precursor dose increased.","subject":{"id":"0e7ccfc7-b9a1-53e0-88f4-a061579ad94d","slug":"indole-3-carbinol","display_name":"Indole-3-carbinol / I3C","entity_type_key":"small_molecule"},"object":{"id":"6918867f-aec7-5aac-b2dc-3d2560092128","slug":"dim-plasma-exposure","display_name":"Plasma DIM exposure","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c8e37aa7-0cbc-5ab0-945f-55947fc3fe5e","stable_key":"182336c6-ed36-5ec6-8a09-25c31096262e:dim-i3c-pk-nonlinear-event","event_type":"observed_intervention","label":"Exposure did not continue rising proportionally as the precursor dose increased.","description":"Mean DIM peak concentration rose from 61 to 607 ng/mL between 400 and 1000 mg I3C, with no further increase at 1200 mg and substantial individual variation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0e7ccfc7-b9a1-53e0-88f4-a061579ad94d","slug":"indole-3-carbinol","display_name":"Indole-3-carbinol / I3C","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6918867f-aec7-5aac-b2dc-3d2560092128","slug":"dim-plasma-exposure","display_name":"Plasma DIM exposure","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/dim-research/17164373.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"610f95545a8b0fa523b17baa7798c2936b9af5bc789257b3fc98bb0aae2bc298\", \"start_char\": 0, \"end_char\": 1606, \"text_sha256\": \"610f95545a8b0fa523b17baa7798c2936b9af5bc789257b3fc98bb0aae2bc298\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Phase I single- and repeated-dose pharmacokinetics","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"I3C single doses 400-1200 mg and repeated-dose follow-up","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"I3C intervention, not purified DIM. Assay detection limits and interindividual variation matter.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"dim","display_name":"3,3'-Diindolylmethane / DIM","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Women given I3C","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Exposure did not continue rising proportionally as the precursor dose increased.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[dim-p17164373] Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmethane. (2006). https://pubmed.ncbi.nlm.nih.gov/17164373/ DOI: 10.1158/1055-9965.epi-06-0396","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma I3C and condensation products","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0eada988-8288-5647-ad92-b2fc9a185be8","evidence_kind":"source_excerpt","locator":"Lines 181-192","start_line":181,"end_line":192,"excerpt":"### dim-i3c-pk-nonlinear\nMean DIM peak concentration rose from 61 to 607 ng/mL between 400 and 1000 mg I3C, with no further increase at 1200 mg and substantial individual variation.\nCondition category: normal\nnutrient_topic: Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Exposure did not continue rising proportionally as the precursor dose increased.\norganism: Women given I3C\ntissue_or_cell_type: Plasma I3C and condensation products\nexperimental_model: Phase I single- and repeated-dose pharmacokinetics\nlimitations: I3C intervention, not purified DIM. Assay detection limits and interindividual variation matter.\nexposure: I3C single doses 400-1200 mg and repeated-dose follow-up\nevidence_span: {\"source_cache\": \"artifacts/dim-research/17164373.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"610f95545a8b0fa523b17baa7798c2936b9af5bc789257b3fc98bb0aae2bc298\", \"start_char\": 0, \"end_char\": 1606, \"text_sha256\": \"610f95545a8b0fa523b17baa7798c2936b9af5bc789257b3fc98bb0aae2bc298\"}\n[dim-p17164373] Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmethane. (2006). https://pubmed.ncbi.nlm.nih.gov/17164373/ DOI: 10.1158/1055-9965.epi-06-0396","model_system":"Phase I single- and repeated-dose pharmacokinetics","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [dim-p17164373] Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmethane. (2006). https://pubmed.ncbi.nlm.nih.gov/17164373/ DOI: 10.1158/1055-9965.epi-06-0396","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b6d70682-97f9-5893-a03c-f9f88836033c","stable_key":"import-182336c6-ed36-5ec6-8a09-25c31096262e","title":"Diindolylmethane (DIM): formation, receptor signaling, metabolism and drug interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"31e14060de904976d2f5d439f2bc9c8a99a72d34626c562c78429025e050d404","revision_id":"611094c1-a9cf-5b9b-b255-ac70b571696a","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}