Component
Digit Symbol-Coding performance
Independently recorded substance, clinical endpoint or assay readout. Claims retain study-specific population and measurement context.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
High folate within low B12 status was associated with greater odds of cognitive impairment defined by Digit Symbol-Coding score below 34 (OR 2.6; 95% CI 1.1–6.1).
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- cross_nutrient
- Does not prove folic acid worsens neurologic injury or that methylfolate resolves B12 deficiency.
- experimental_model
- Cross-sectional NHANES 1999–2002 sample of 1459 older adults with normal creatinine and specified clinical exclusions. Cognitive analysis n=1302.
- exposure
- Measured serum folate and B12/MMA; low B12 defined as serum B12 <148 pmol/L or MMA >210 nmol/L; high folate >59 nmol/L.
- limitations
- An association in one test is not causal dementia evidence. In B12-normal participants, high folate was associated with lower impairment odds.
- nutrient_topic
- Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. · Folate (vitamin B9)
- organism
- Homo sapiens
- plain_language
- The observed folate–cognition relationship depended on B12 status.
- primary_references
- [fol-morris2007] Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification (2007). https://pubmed.ncbi.nlm.nih.gov/17209196/ DOI: 10.1093/ajcn/85.1.193
- tissue_or_cell_type
- Human blood or whole-person clinical endpoints
- trigger_kind
- biomarker_context Imported condition classification; unverified.
Folate and folic acid: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1554–1565
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Cross-sectional NHANES 1999–2002 sample of 1459 older adults with normal creatinine and specified clinical exclusions. Cognitive analysis n=1302. · source_derived_draft · unverified_draft
### fol-b12-low-high-folate-cognition High folate within low B12 status was associated with greater odds of cognitive impairment defined by Digit Symbol-Coding score below 34 (OR 2.6; 95% CI 1.1–6.1). Condition category: biomarker_context nutrient_topic: Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: The observed folate–cognition relationship depended on B12 status. organism: Homo sapiens tissue_or_cell_type: Human blood or whole-person clinical endpoints experimental_model: Cross-sectional NHANES 1999–2002 sample of 1459 older adults with normal creatinine and specified clinical exclusions. Cognitive analysis n=1302. limitations: An association in one test is not causal dementia evidence. In B12-normal participants, high folate was associated with lower impairment odds. exposure: Measured serum folate and B12/MMA; low B12 defined as serum B12 <148 pmol/L or MMA >210 nmol/L; high folate >59 nmol/L. cross_nutrient: Does not prove folic acid worsens neurologic injury or that methylfolate resolves B12 deficiency. [fol-morris2007] Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification (2007). https://pubmed.ncbi.nlm.nih.gov/17209196/ DOI: 10.1093/ajcn/85.1.193
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.