Dietary phosphate intake normalized to total energy intake: molecular mechanisms & dependencies

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

Human evidence only

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

Higher reported phosphate intake was associated with lower resting ATP synthesis (r=−0.62, p=0.03) in the 13-person pilot.
Dietary phosphate intake normalized to total energy intake → Human skeletal-muscle ATP synthetic flux by 31P-MRS source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/phosphorus-research/38482570.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "11f6599b477ce87228e00e4d562eb0c70615dceebb82a983188e9b0fcd8e730f", "start_char": 0, "end_char": 2164, "text_sha256": "11f6599b477ce87228e00e4d562eb0c70615dceebb82a983188e9b0fcd8e730f"}
experimental_model
Small cross-sectional diet-recall and 31P-MRS association study
exposure
24-hour dietary recall normalized to energy; calf-muscle MRS at rest/exercise
limitations
Observational pilot with n=13, not a controlled excess-phosphate intervention. The source uses a phosphocreatinine wording error; PCr is represented as phosphocreatine.
nutrient_topic
Phosphorus research collection; topical membership is not evidence of a direct dietary effect. · Phosphorus
organism
Human
plain_language
More reported dietary phosphorus did not imply better energetics; this association does not establish causation.
primary_references
[phosphorus-p38482570] Association between dietary phosphate intake and skeletal muscle energetics in adults without cardiovascular disease. (2024). https://pubmed.ncbi.nlm.nih.gov/38482570/ DOI: 10.1152/japplphysiol.00818.2023
tissue_or_cell_type
Thirteen adults without cardiopulmonary disease
Phosphorus: metabolism, signaling and nutrient connections (2026-09-17) · lines 1245–1256
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Small cross-sectional diet-recall and 31P-MRS association study · source_derived_draft · unverified_draft
### phosphorus-high-intake-atp-association Higher reported phosphate intake was associated with lower resting ATP synthesis (r=−0.62, p=0.03) in the 13-person pilot. Condition category: normal nutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect. plain_language: More reported dietary phosphorus did not imply better energetics; this association does not establish causation. organism: Human tissue_or_cell_type: Thirteen adults without cardiopulmonary disease experimental_model: Small cross-sectional diet-recall and 31P-MRS association study limitations: Observational pilot with n=13, not a controlled excess-phosphate intervention. The source uses a phosphocreatinine wording error; PCr is represented as phosphocreatine. exposure: 24-hour dietary recall normalized to energy; calf-muscle MRS at rest/exercise evidence_span: {"source_cache": "artifacts/phosphorus-research/38482570.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "11f6599b477ce87228e00e4d562eb0c70615dceebb82a983188e9b0fcd8e730f", "start_char": 0, "end_char": 2164, "text_sha256": "11f6599b477ce87228e00e4d562eb0c70615dceebb82a983188e9b0fcd8e730f"} [phosphorus-p38482570] Association between dietary phosphate intake and skeletal muscle energetics in adults without cardiovascular disease. (2024). https://pubmed.ncbi.nlm.nih.gov/38482570/ DOI: 10.1152/japplphysiol.00818.2023
Complete structured claim and evidence
Higher reported phosphate intake was associated with greater exercise-related phosphocreatine depletion in the pilot.
Dietary phosphate intake normalized to total energy intake → Human muscle phosphocreatine depletion during exercise source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/phosphorus-research/38482570.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "11f6599b477ce87228e00e4d562eb0c70615dceebb82a983188e9b0fcd8e730f", "start_char": 0, "end_char": 2164, "text_sha256": "11f6599b477ce87228e00e4d562eb0c70615dceebb82a983188e9b0fcd8e730f"}
experimental_model
Small cross-sectional diet-recall and 31P-MRS association study
exposure
24-hour dietary recall normalized to energy; calf-muscle MRS at rest/exercise
limitations
Observational pilot with n=13, not a controlled excess-phosphate intervention. The source uses a phosphocreatinine wording error; PCr is represented as phosphocreatine.
nutrient_topic
Phosphorus research collection; topical membership is not evidence of a direct dietary effect. · Phosphorus
organism
Human
plain_language
The phosphocreatine response also differed with reported intake.
primary_references
[phosphorus-p38482570] Association between dietary phosphate intake and skeletal muscle energetics in adults without cardiovascular disease. (2024). https://pubmed.ncbi.nlm.nih.gov/38482570/ DOI: 10.1152/japplphysiol.00818.2023
tissue_or_cell_type
Thirteen adults without cardiopulmonary disease
Phosphorus: metabolism, signaling and nutrient connections (2026-09-17) · lines 1258–1269
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Small cross-sectional diet-recall and 31P-MRS association study · source_derived_draft · unverified_draft
### phosphorus-high-intake-pcr Higher reported phosphate intake was associated with greater exercise-related phosphocreatine depletion in the pilot. Condition category: normal nutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect. plain_language: The phosphocreatine response also differed with reported intake. organism: Human tissue_or_cell_type: Thirteen adults without cardiopulmonary disease experimental_model: Small cross-sectional diet-recall and 31P-MRS association study limitations: Observational pilot with n=13, not a controlled excess-phosphate intervention. The source uses a phosphocreatinine wording error; PCr is represented as phosphocreatine. exposure: 24-hour dietary recall normalized to energy; calf-muscle MRS at rest/exercise evidence_span: {"source_cache": "artifacts/phosphorus-research/38482570.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "11f6599b477ce87228e00e4d562eb0c70615dceebb82a983188e9b0fcd8e730f", "start_char": 0, "end_char": 2164, "text_sha256": "11f6599b477ce87228e00e4d562eb0c70615dceebb82a983188e9b0fcd8e730f"} [phosphorus-p38482570] Association between dietary phosphate intake and skeletal muscle energetics in adults without cardiovascular disease. (2024). https://pubmed.ncbi.nlm.nih.gov/38482570/ DOI: 10.1152/japplphysiol.00818.2023
Complete structured claim and evidence

The events it takes part in

A mechanism often involves more than two components. These are the full events, with every participant and its role.

Situations it appears in

Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.

In the sources

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Open hypotheses

Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.

This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

Dietary phosphate intake normalized to total energy intake