{"id":"fa2fe2fe-cfeb-51e0-85cf-5bf08da0a792","stable_key":"fe6af7fc-7372-5c4f-9c2f-2bbf56695397:phosphorus-high-intake-atp-association","predicate":"is_inversely_associated_with","statement":"Higher reported phosphate intake was associated with lower resting ATP synthesis (r=−0.62, p=0.03) in the 13-person pilot.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"81dbc63d-f768-5ca0-9fc6-1083713ed7c1","mechanism_event_label":"More reported dietary phosphorus did not imply better energetics; this association does not establish causation.","subject":{"id":"1f7aade3-9bb2-584b-a71c-638dd878f6e9","slug":"dietary-phosphate-intake-density","display_name":"Dietary phosphate intake normalized to total energy intake","entity_type_key":"cellular_process"},"object":{"id":"31cb5a3d-e5e6-528f-bfc5-8395c826f0db","slug":"human-muscle-atp-synthetic-flux","display_name":"Human skeletal-muscle ATP synthetic flux by 31P-MRS","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"81dbc63d-f768-5ca0-9fc6-1083713ed7c1","stable_key":"fe6af7fc-7372-5c4f-9c2f-2bbf56695397:phosphorus-high-intake-atp-association-event","event_type":"observed_intervention","label":"More reported dietary phosphorus did not imply better energetics; this association does not establish causation.","description":"Higher reported phosphate intake was associated with lower resting ATP synthesis (r=−0.62, p=0.03) in the 13-person pilot.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1f7aade3-9bb2-584b-a71c-638dd878f6e9","slug":"dietary-phosphate-intake-density","display_name":"Dietary phosphate intake normalized to total energy intake","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"31cb5a3d-e5e6-528f-bfc5-8395c826f0db","slug":"human-muscle-atp-synthetic-flux","display_name":"Human skeletal-muscle ATP synthetic flux by 31P-MRS","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/phosphorus-research/38482570.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"11f6599b477ce87228e00e4d562eb0c70615dceebb82a983188e9b0fcd8e730f\", \"start_char\": 0, \"end_char\": 2164, \"text_sha256\": \"11f6599b477ce87228e00e4d562eb0c70615dceebb82a983188e9b0fcd8e730f\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Small cross-sectional diet-recall and 31P-MRS association study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"24-hour dietary recall normalized to energy; calf-muscle MRS at rest/exercise","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Observational pilot with n=13, not a controlled excess-phosphate intervention. The source uses a phosphocreatinine wording error; PCr is represented as phosphocreatine.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Phosphorus research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"phosphorus","display_name":"Phosphorus","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"More reported dietary phosphorus did not imply better energetics; this association does not establish causation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[phosphorus-p38482570] Association between dietary phosphate intake and skeletal muscle energetics in adults without cardiovascular disease. (2024). https://pubmed.ncbi.nlm.nih.gov/38482570/ DOI: 10.1152/japplphysiol.00818.2023","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Thirteen adults without cardiopulmonary disease","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4896c7df-302a-5e0e-856e-ed07550a41de","evidence_kind":"source_excerpt","locator":"Lines 1245-1256","start_line":1245,"end_line":1256,"excerpt":"### phosphorus-high-intake-atp-association\nHigher reported phosphate intake was associated with lower resting ATP synthesis (r=−0.62, p=0.03) in the 13-person pilot.\nCondition category: normal\nnutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: More reported dietary phosphorus did not imply better energetics; this association does not establish causation.\norganism: Human\ntissue_or_cell_type: Thirteen adults without cardiopulmonary disease\nexperimental_model: Small cross-sectional diet-recall and 31P-MRS association study\nlimitations: Observational pilot with n=13, not a controlled excess-phosphate intervention. The source uses a phosphocreatinine wording error; PCr is represented as phosphocreatine.\nexposure: 24-hour dietary recall normalized to energy; calf-muscle MRS at rest/exercise\nevidence_span: {\"source_cache\": \"artifacts/phosphorus-research/38482570.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"11f6599b477ce87228e00e4d562eb0c70615dceebb82a983188e9b0fcd8e730f\", \"start_char\": 0, \"end_char\": 2164, \"text_sha256\": \"11f6599b477ce87228e00e4d562eb0c70615dceebb82a983188e9b0fcd8e730f\"}\n[phosphorus-p38482570] Association between dietary phosphate intake and skeletal muscle energetics in adults without cardiovascular disease. (2024). https://pubmed.ncbi.nlm.nih.gov/38482570/ DOI: 10.1152/japplphysiol.00818.2023","model_system":"Small cross-sectional diet-recall and 31P-MRS association study","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [phosphorus-p38482570] Association between dietary phosphate intake and skeletal muscle energetics in adults without cardiovascular disease. (2024). https://pubmed.ncbi.nlm.nih.gov/38482570/ DOI: 10.1152/japplphysiol.00818.2023","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"cfdefe70-3a09-5e2e-97c8-46626382e4b4","stable_key":"import-fe6af7fc-7372-5c4f-9c2f-2bbf56695397","title":"Phosphorus: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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