Component
Adenoviral DES1 expression
Human DES1 overexpression after intravitreal adenoviral delivery; cellular targeting was not exclusive.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Intravitreal adenovirus expressing human DES1 increased retinal 9-cis-retinal in Rpe65-null mice relative to the RFP control virus.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- false
- evidence_location
- Figure 4a; Results: Gene therapy of rpe65-null mice
- experimental_model
- Adenoviral human DES1 versus RFP in Rpe65-null mice
- exposure
- Retinoids measured one day after injection; Figure 4a without added intravitreal retinol.
- limitations
- 11-cis-retinoids remained undetectable in this comparison; viral cell targeting was not exclusive.
- nutrient
- Vitamin A · Vitamin A
- nutrient_topic
- Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
- organism
- Homo sapiens transgene in Mus musculus
- plain_language
- Extra DES1 increased an alternative cis-retinal isomer in the mutant eyes.
- primary_references
- [vav-kaylor2013] Identification of DES1 as a vitamin A isomerase in Müller glial cells of the retina. (2013). https://pubmed.ncbi.nlm.nih.gov/23143414/ DOI: 10.1038/nchembio.1114
- tissue_or_cell_type
- retina
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin A expansion: reproduction, light-driven vision and shared mechanisms (2026-09-17) · lines 603–616
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Adenoviral human DES1 versus RFP in Rpe65-null mice · source_derived_draft · unverified_draft
### vae-des1-gene-transfer-9cis Intravitreal adenovirus expressing human DES1 increased retinal 9-cis-retinal in Rpe65-null mice relative to the RFP control virus. Condition category: machinery_impairment nutrient_topic: Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. plain_language: Extra DES1 increased an alternative cis-retinal isomer in the mutant eyes. organism: Homo sapiens transgene in Mus musculus tissue_or_cell_type: retina experimental_model: Adenoviral human DES1 versus RFP in Rpe65-null mice limitations: 11-cis-retinoids remained undetectable in this comparison; viral cell targeting was not exclusive. exposure: Retinoids measured one day after injection; Figure 4a without added intravitreal retinol. cross_nutrient: false evidence_location: Figure 4a; Results: Gene therapy of rpe65-null mice nutrient: Vitamin A [vav-kaylor2013] Identification of DES1 as a vitamin A isomerase in Müller glial cells of the retina. (2013). https://pubmed.ncbi.nlm.nih.gov/23143414/ DOI: 10.1038/nchembio.1114
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.