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(2013). https://pubmed.ncbi.nlm.nih.gov/23143414/ DOI: 10.1038/nchembio.1114","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"retina","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"8968a7aa-87ee-5ece-be2a-46d01b9f7d6f","evidence_kind":"source_excerpt","locator":"Lines 603-616","start_line":603,"end_line":616,"excerpt":"### vae-des1-gene-transfer-9cis\nIntravitreal adenovirus expressing human DES1 increased retinal 9-cis-retinal in Rpe65-null mice relative to the RFP control virus.\nCondition category: machinery_impairment\nnutrient_topic: Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Extra DES1 increased an alternative cis-retinal isomer in the mutant eyes.\norganism: Homo sapiens transgene in Mus musculus\ntissue_or_cell_type: retina\nexperimental_model: Adenoviral human DES1 versus RFP in Rpe65-null mice\nlimitations: 11-cis-retinoids remained undetectable in this comparison; viral cell targeting was not exclusive.\nexposure: Retinoids measured one day after injection; Figure 4a without added intravitreal retinol.\ncross_nutrient: false\nevidence_location: Figure 4a; Results: Gene therapy of rpe65-null mice\nnutrient: Vitamin A\n[vav-kaylor2013] Identification of DES1 as a vitamin A isomerase in Müller glial cells of the retina. 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