Component

Cyclosporine A / ciclosporin A

Cyclosporine A / ciclosporin A. Species, exposure and limitations are retained in each linked claim.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. In six transplant recipients, cyclosporine AUC rose 34.5% after 12 days of berberine.

    Berberine → Cyclosporine A / ciclosporin A source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/berberine-research/16133554.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7a86b1b0f9ad77889da596b013f9f229556d53d825dac1b8bb2ba6ed094a68ad", "start_char": 0, "end_char": 2232, "text_sha256": "7a86b1b0f9ad77889da596b013f9f229556d53d825dac1b8bb2ba6ed094a68ad"}
    experimental_model
    Randomized controlled transplant study with separate six-person pharmacokinetic arm
    exposure
    52 recipients per clinical arm; berberine 0.2 g three times daily for three months; six-person 12-day PK comparison
    limitations
    Observed interaction is clinically relevant, but the proposed CYP3A4 explanation was not uniquely established. Baseline change and between-group difference must not be confused.
    nutrient_topic
    Berberine research collection; topical membership is not evidence of a direct dietary effect. · Berberine
    organism
    Renal-transplant recipients
    plain_language
    A pharmacokinetic subset confirmed increased exposure; it is not an instruction to lower the prescribed dose.
    primary_references
    [berberine-p16133554] Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. (2005). https://pubmed.ncbi.nlm.nih.gov/16133554/ DOI: 10.1007/s00228-005-0952-3
    tissue_or_cell_type
    Cyclosporine blood concentrations

    Berberine: metabolism, nutrient connections and drug interactions (2026-09-17) · lines 727–738

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized controlled transplant study with separate six-person pharmacokinetic arm · source_derived_draft · unverified_draft

    ### berberine-cyclosporine-pk In six transplant recipients, cyclosporine AUC rose 34.5% after 12 days of berberine. Condition category: normal nutrient_topic: Berberine research collection; topical membership is not evidence of a direct dietary effect. plain_language: A pharmacokinetic subset confirmed increased exposure; it is not an instruction to lower the prescribed dose. organism: Renal-transplant recipients tissue_or_cell_type: Cyclosporine blood concentrations experimental_model: Randomized controlled transplant study with separate six-person pharmacokinetic arm limitations: Observed interaction is clinically relevant, but the proposed CYP3A4 explanation was not uniquely established. Baseline change and between-group difference must not be confused. exposure: 52 recipients per clinical arm; berberine 0.2 g three times daily for three months; six-person 12-day PK comparison evidence_span: {"source_cache": "artifacts/berberine-research/16133554.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7a86b1b0f9ad77889da596b013f9f229556d53d825dac1b8bb2ba6ed094a68ad", "start_char": 0, "end_char": 2232, "text_sha256": "7a86b1b0f9ad77889da596b013f9f229556d53d825dac1b8bb2ba6ed094a68ad"} [berberine-p16133554] Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. (2005). https://pubmed.ncbi.nlm.nih.gov/16133554/ DOI: 10.1007/s00228-005-0952-3
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Final cyclosporine concentrations were 29.3% higher in the berberine-treated group than in the group without berberine.

    Berberine → Blood cyclosporine exposure source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/berberine-research/16133554.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7a86b1b0f9ad77889da596b013f9f229556d53d825dac1b8bb2ba6ed094a68ad", "start_char": 0, "end_char": 2232, "text_sha256": "7a86b1b0f9ad77889da596b013f9f229556d53d825dac1b8bb2ba6ed094a68ad"}
    experimental_model
    Randomized controlled transplant study with separate six-person pharmacokinetic arm
    exposure
    52 recipients per clinical arm; berberine 0.2 g three times daily for three months; six-person 12-day PK comparison
    limitations
    Observed interaction is clinically relevant, but the proposed CYP3A4 explanation was not uniquely established. Baseline change and between-group difference must not be confused.
    nutrient_topic
    Berberine research collection; topical membership is not evidence of a direct dietary effect. · Berberine
    organism
    Renal-transplant recipients
    plain_language
    A transplant medicine had higher blood concentrations with berberine.
    primary_references
    [berberine-p16133554] Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. (2005). https://pubmed.ncbi.nlm.nih.gov/16133554/ DOI: 10.1007/s00228-005-0952-3
    tissue_or_cell_type
    Cyclosporine blood concentrations

    Berberine: metabolism, nutrient connections and drug interactions (2026-09-17) · lines 714–725

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized controlled transplant study with separate six-person pharmacokinetic arm · source_derived_draft · unverified_draft

    ### berberine-cyclosporine-clinical Final cyclosporine concentrations were 29.3% higher in the berberine-treated group than in the group without berberine. Condition category: normal nutrient_topic: Berberine research collection; topical membership is not evidence of a direct dietary effect. plain_language: A transplant medicine had higher blood concentrations with berberine. organism: Renal-transplant recipients tissue_or_cell_type: Cyclosporine blood concentrations experimental_model: Randomized controlled transplant study with separate six-person pharmacokinetic arm limitations: Observed interaction is clinically relevant, but the proposed CYP3A4 explanation was not uniquely established. Baseline change and between-group difference must not be confused. exposure: 52 recipients per clinical arm; berberine 0.2 g three times daily for three months; six-person 12-day PK comparison evidence_span: {"source_cache": "artifacts/berberine-research/16133554.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7a86b1b0f9ad77889da596b013f9f229556d53d825dac1b8bb2ba6ed094a68ad", "start_char": 0, "end_char": 2232, "text_sha256": "7a86b1b0f9ad77889da596b013f9f229556d53d825dac1b8bb2ba6ed094a68ad"} [berberine-p16133554] Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. (2005). https://pubmed.ncbi.nlm.nih.gov/16133554/ DOI: 10.1007/s00228-005-0952-3
    Complete structured claim and evidence

  2. The 3 mg/kg cyclosporine arm showed a 19.2% AUC increase with berberine.

    Berberine → Blood cyclosporine exposure source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/berberine-research/16541194.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1e1c8258a18a8214a1124f3624eff9cb67151c5f54393ff2e3e7322b3bdf53b5", "start_char": 0, "end_char": 1615, "text_sha256": "1e1c8258a18a8214a1124f3624eff9cb67151c5f54393ff2e3e7322b3bdf53b5"}
    experimental_model
    Two small healthy-volunteer pharmacokinetic experiments
    exposure
    3 mg/kg cyclosporine with a single 0.3 g berberine dose; separate 6 mg/kg cyclosporine after 10 days of berberine
    limitations
    Different cyclosporine doses and berberine schedules limit direct comparison. A null arm does not negate the positive arm or transplant finding.
    nutrient_topic
    Berberine research collection; topical membership is not evidence of a direct dietary effect. · Berberine
    organism
    Two groups of six healthy male volunteers
    plain_language
    Interaction size depended on the tested regimen.
    primary_references
    [berberine-p16541194] The effects of berberine on the pharmacokinetics of cyclosporin A in healthy volunteers. (2006). https://pubmed.ncbi.nlm.nih.gov/16541194/ DOI: 10.1358/mf.2006.28.1.962774
    tissue_or_cell_type
    Cyclosporine pharmacokinetics

    Berberine: metabolism, nutrient connections and drug interactions (2026-09-17) · lines 740–751

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Two small healthy-volunteer pharmacokinetic experiments · source_derived_draft · unverified_draft

    ### berberine-cyclosporine-low-dose The 3 mg/kg cyclosporine arm showed a 19.2% AUC increase with berberine. Condition category: normal nutrient_topic: Berberine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Interaction size depended on the tested regimen. organism: Two groups of six healthy male volunteers tissue_or_cell_type: Cyclosporine pharmacokinetics experimental_model: Two small healthy-volunteer pharmacokinetic experiments limitations: Different cyclosporine doses and berberine schedules limit direct comparison. A null arm does not negate the positive arm or transplant finding. exposure: 3 mg/kg cyclosporine with a single 0.3 g berberine dose; separate 6 mg/kg cyclosporine after 10 days of berberine evidence_span: {"source_cache": "artifacts/berberine-research/16541194.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1e1c8258a18a8214a1124f3624eff9cb67151c5f54393ff2e3e7322b3bdf53b5", "start_char": 0, "end_char": 1615, "text_sha256": "1e1c8258a18a8214a1124f3624eff9cb67151c5f54393ff2e3e7322b3bdf53b5"} [berberine-p16541194] The effects of berberine on the pharmacokinetics of cyclosporin A in healthy volunteers. (2006). https://pubmed.ncbi.nlm.nih.gov/16541194/ DOI: 10.1358/mf.2006.28.1.962774
    Complete structured claim and evidence

  3. The separate 6 mg/kg cyclosporine arm found no significant pharmacokinetic change after repeated berberine.

    Berberine → Blood cyclosporine exposure source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/berberine-research/16541194.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1e1c8258a18a8214a1124f3624eff9cb67151c5f54393ff2e3e7322b3bdf53b5", "start_char": 0, "end_char": 1615, "text_sha256": "1e1c8258a18a8214a1124f3624eff9cb67151c5f54393ff2e3e7322b3bdf53b5"}
    experimental_model
    Two small healthy-volunteer pharmacokinetic experiments
    exposure
    3 mg/kg cyclosporine with a single 0.3 g berberine dose; separate 6 mg/kg cyclosporine after 10 days of berberine
    limitations
    Different cyclosporine doses and berberine schedules limit direct comparison. A null arm does not negate the positive arm or transplant finding.
    nutrient_topic
    Berberine research collection; topical membership is not evidence of a direct dietary effect. · Berberine
    organism
    Two groups of six healthy male volunteers
    plain_language
    Both outcomes remain visible with their distinct dosing conditions.
    primary_references
    [berberine-p16541194] The effects of berberine on the pharmacokinetics of cyclosporin A in healthy volunteers. (2006). https://pubmed.ncbi.nlm.nih.gov/16541194/ DOI: 10.1358/mf.2006.28.1.962774
    tissue_or_cell_type
    Cyclosporine pharmacokinetics

    Berberine: metabolism, nutrient connections and drug interactions (2026-09-17) · lines 753–764

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Two small healthy-volunteer pharmacokinetic experiments · source_derived_draft · unverified_draft

    ### berberine-cyclosporine-null-arm The separate 6 mg/kg cyclosporine arm found no significant pharmacokinetic change after repeated berberine. Condition category: normal nutrient_topic: Berberine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Both outcomes remain visible with their distinct dosing conditions. organism: Two groups of six healthy male volunteers tissue_or_cell_type: Cyclosporine pharmacokinetics experimental_model: Two small healthy-volunteer pharmacokinetic experiments limitations: Different cyclosporine doses and berberine schedules limit direct comparison. A null arm does not negate the positive arm or transplant finding. exposure: 3 mg/kg cyclosporine with a single 0.3 g berberine dose; separate 6 mg/kg cyclosporine after 10 days of berberine evidence_span: {"source_cache": "artifacts/berberine-research/16541194.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1e1c8258a18a8214a1124f3624eff9cb67151c5f54393ff2e3e7322b3bdf53b5", "start_char": 0, "end_char": 1615, "text_sha256": "1e1c8258a18a8214a1124f3624eff9cb67151c5f54393ff2e3e7322b3bdf53b5"} [berberine-p16541194] The effects of berberine on the pharmacokinetics of cyclosporin A in healthy volunteers. (2006). https://pubmed.ncbi.nlm.nih.gov/16541194/ DOI: 10.1358/mf.2006.28.1.962774
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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