Component
CXCL10
Interferon-inducible chemokine and ligand of CXCR3.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Molecular dynamics simulations indicated lariciresinol was a high-affinity ligand for CXCL10.
Experimental context and source evidence
- duration
- Not applicable
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- experimental_model
- Molecular docking and molecular dynamics simulation
- exposure
- Lariciresinol, selected among gut microbiota metabolites in a network analysis
- limitations
- A simulated binding result. The study is computational with unspecified in vitro validation and its authors describe it as hypothesis-generating; no cell line, knockdown or binding measurement is reported in the abstract.
- organism
- Molecular docking and molecular dynamics simulation
- plain_language
- Molecular dynamics simulations indicated lariciresinol was a high-affinity ligand for CXCL10.
- primary_references
- Integrative multi-omics analysis identifies CXCL10 as a gut microbiota-associated target in breast cancer. (2025). https://pubmed.ncbi.nlm.nih.gov/41298864/ DOI: 10.1186/s13568-025-01989-0
- route
- In silico
- tissue
- Ligand binding to a chemokine
Lariciresinol: five molecules under one name, and the mechanisms each one carries (2026-09-22) · lines 242–251
Original AI-assisted curation of twelve primary studies, every abstract read and all DOIs cross-checked against live PubMed metadata. Mechanism edges only, with no conclusion or claim of benefit recorded. Three author clusters account for eight of the twelve and carry shared laboratory keys. Study-specific concentrations, negative findings and limitations retained. Not publisher full text. · supports · · source_derived_draft · unverified_draft
## lariciresinol-binds-cxcl10 Molecular dynamics simulations indicated lariciresinol was a high-affinity ligand for CXCL10. Model/species: Molecular docking and molecular dynamics simulation Tissue/system: Ligand binding to a chemokine Exposure: Lariciresinol, selected among gut microbiota metabolites in a network analysis Route: In silico Duration: Not applicable Limits: A simulated binding result. The study is computational with unspecified in vitro validation and its authors describe it as hypothesis-generating; no cell line, knockdown or binding measurement is reported in the abstract. Primary reference: Integrative multi-omics analysis identifies CXCL10 as a gut microbiota-associated target in breast cancer. (2025). https://pubmed.ncbi.nlm.nih.gov/41298864/ DOI: 10.1186/s13568-025-01989-0 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.