{"id":"673451cc-4008-5d3c-bcae-e333a90e542c","stable_key":"96d9034a-2550-5f3c-b767-1767c982533c:lariciresinol-binds-cxcl10","predicate":"binds","statement":"Molecular dynamics simulations indicated lariciresinol was a high-affinity ligand for CXCL10.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"cc8a1372-bc79-5074-aee8-7e297f845776","mechanism_event_label":"Molecular dynamics simulations indicated lariciresinol was a high-affinity ligand for CXCL10.","subject":{"id":"4fcf5405-bafb-54bf-89b8-2fc11e0d9822","slug":"lariciresinol","display_name":"Lariciresinol, enantiomer unresolved","entity_type_key":"small_molecule"},"object":{"id":"aac44dc9-2d8d-5a8a-8fc8-3ad1c590eb66","slug":"cxcl10","display_name":"CXCL10","entity_type_key":"cytokine"},"evidence_count":1,"mechanism_event":{"id":"cc8a1372-bc79-5074-aee8-7e297f845776","stable_key":"96d9034a-2550-5f3c-b767-1767c982533c:lariciresinol-binds-cxcl10-event","event_type":"observed_relationship","label":"Molecular dynamics simulations indicated lariciresinol was a high-affinity ligand for CXCL10.","description":"Molecular dynamics simulations indicated lariciresinol was a high-affinity ligand for CXCL10.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4fcf5405-bafb-54bf-89b8-2fc11e0d9822","slug":"lariciresinol","display_name":"Lariciresinol, enantiomer unresolved","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"aac44dc9-2d8d-5a8a-8fc8-3ad1c590eb66","slug":"cxcl10","display_name":"CXCL10","entity_type_key":"cytokine"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"Not applicable","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Molecular docking and molecular dynamics simulation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Lariciresinol, selected among gut microbiota metabolites in a network analysis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A simulated binding result. The study is computational with unspecified in vitro validation and its authors describe it as hypothesis-generating; no cell line, knockdown or binding measurement is reported in the abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Molecular docking and molecular dynamics simulation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Molecular dynamics simulations indicated lariciresinol was a high-affinity ligand for CXCL10.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Integrative multi-omics analysis identifies CXCL10 as a gut microbiota-associated target in breast cancer. (2025). https://pubmed.ncbi.nlm.nih.gov/41298864/ DOI: 10.1186/s13568-025-01989-0","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In silico","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Ligand binding to a chemokine","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"343222c0-05a9-57c2-8909-c7820aff46fb","evidence_kind":"source_excerpt","locator":"Lines 242-251","start_line":242,"end_line":251,"excerpt":"## lariciresinol-binds-cxcl10\nMolecular dynamics simulations indicated lariciresinol was a high-affinity ligand for CXCL10.\nModel/species: Molecular docking and molecular dynamics simulation\nTissue/system: Ligand binding to a chemokine\nExposure: Lariciresinol, selected among gut microbiota metabolites in a network analysis\nRoute: In silico\nDuration: Not applicable\nLimits: A simulated binding result. The study is computational with unspecified in vitro validation and its authors describe it as hypothesis-generating; no cell line, knockdown or binding measurement is reported in the abstract.\nPrimary reference: Integrative multi-omics analysis identifies CXCL10 as a gut microbiota-associated target in breast cancer. (2025). https://pubmed.ncbi.nlm.nih.gov/41298864/ DOI: 10.1186/s13568-025-01989-0\nAccess: Primary PubMed abstract and indexed metadata reviewed. 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