Component
Coumarin-derived covalent binding to human liver microsomal proteins
Coumarin-derived covalent binding to human liver microsomal proteins. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Coumarin-derived material bound covalently to human microsomal proteins, averaging 4.8 pmol/min/mg.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/coumarin-research/7839702.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ca24fcb6d3561aa6605b2a53ff463aa6e2ca085d785d1f77615498580d84e909", "start_char": 0, "end_char": 1457, "text_sha256": "ca24fcb6d3561aa6605b2a53ff463aa6e2ca085d785d1f77615498580d84e909"}
- experimental_model
- Radiolabeled substrate metabolism in 12 human liver microsomal samples
- exposure
- 50 micromolar [3-14C]coumarin
- limitations
- Donor-panel correlations do not assign enzyme causality; older grouping of 3-hydroxylation products is not adopted as an epoxide mechanism.
- nutrient_topic
- Coumarin research collection; topical membership is not evidence of a direct dietary effect. · Coumarin
- organism
- Human
- plain_language
- A small measured fraction became attached to proteins.
- primary_references
- [coumarin-p7839702] Metabolism of [3-14C] coumarin by human liver microsomes. (1994). https://pubmed.ncbi.nlm.nih.gov/7839702/ DOI: 10.3109/00498259409043279
- tissue_or_cell_type
- Liver microsomes
Coumarin: metabolism, signaling and nutrient connections (2026-09-17) · lines 202–213
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Radiolabeled substrate metabolism in 12 human liver microsomal samples · source_derived_draft · unverified_draft
### coumarin-microsomal-binding Coumarin-derived material bound covalently to human microsomal proteins, averaging 4.8 pmol/min/mg. Condition category: normal nutrient_topic: Coumarin research collection; topical membership is not evidence of a direct dietary effect. plain_language: A small measured fraction became attached to proteins. organism: Human tissue_or_cell_type: Liver microsomes experimental_model: Radiolabeled substrate metabolism in 12 human liver microsomal samples limitations: Donor-panel correlations do not assign enzyme causality; older grouping of 3-hydroxylation products is not adopted as an epoxide mechanism. exposure: 50 micromolar [3-14C]coumarin evidence_span: {"source_cache": "artifacts/coumarin-research/7839702.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ca24fcb6d3561aa6605b2a53ff463aa6e2ca085d785d1f77615498580d84e909", "start_char": 0, "end_char": 1457, "text_sha256": "ca24fcb6d3561aa6605b2a53ff463aa6e2ca085d785d1f77615498580d84e909"} [coumarin-p7839702] Metabolism of [3-14C] coumarin by human liver microsomes. (1994). https://pubmed.ncbi.nlm.nih.gov/7839702/ DOI: 10.3109/00498259409043279
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.