Component
CT coronary artery calcium score
CT coronary artery calcium score. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Median CAC rose from 135 to 184 with MK-7 and from 145 to 214 with placebo over two years; adjusted group trajectories differed (P=0.02).
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/k2-research/42268593.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8bd6d3cb0722f549b8a9c8f06feba3165dfd421c4ce0658b75b90a6e64e84a4b", "start_char": 0, "end_char": 2890, "text_sha256": "8bd6d3cb0722f549b8a9c8f06feba3165dfd421c4ce0658b75b90a6e64e84a4b"}
- experimental_model
- Two-year randomized placebo-controlled VitaK-CAC trial
- exposure
- MK-7 360 micrograms/day; baseline CAC 50–400
- limitations
- Published 2026; imaging surrogate, not demonstrated fewer infarctions, improved plaque stability or arterial calcium removal. One author disclosed grants from Gnosis and shares in Coagulation Profile outside this work.
- nutrient_topic
- Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin K2 / menaquinone family
- organism
- 180 randomized symptomatic coronary-disease patients; 85 received MK-7 and 82 placebo
- plain_language
- Calcification still increased in both groups, but progressed more slowly with MK-7 in this trial.
- primary_references
- [k2-p42268593] Two Years of Menaquinone-7 Supplementation and Coronary Artery Calcification: A Randomized Clinical Trial. (2026). https://pubmed.ncbi.nlm.nih.gov/42268593/ DOI: 10.1001/jamacardio.2026.1279
- tissue_or_cell_type
- Coronary CT calcium score and calcium mass
Vitamin K2: menaquinone forms, carboxylation, recycling and nutrient interactions (2026-09-17) · lines 1228–1239
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Two-year randomized placebo-controlled VitaK-CAC trial · source_derived_draft · unverified_draft
### k2-vitak-cac Median CAC rose from 135 to 184 with MK-7 and from 145 to 214 with placebo over two years; adjusted group trajectories differed (P=0.02). Condition category: normal nutrient_topic: Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. plain_language: Calcification still increased in both groups, but progressed more slowly with MK-7 in this trial. organism: 180 randomized symptomatic coronary-disease patients; 85 received MK-7 and 82 placebo tissue_or_cell_type: Coronary CT calcium score and calcium mass experimental_model: Two-year randomized placebo-controlled VitaK-CAC trial limitations: Published 2026; imaging surrogate, not demonstrated fewer infarctions, improved plaque stability or arterial calcium removal. One author disclosed grants from Gnosis and shares in Coagulation Profile outside this work. exposure: MK-7 360 micrograms/day; baseline CAC 50–400 evidence_span: {"source_cache": "artifacts/k2-research/42268593.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "8bd6d3cb0722f549b8a9c8f06feba3165dfd421c4ce0658b75b90a6e64e84a4b", "start_char": 0, "end_char": 2890, "text_sha256": "8bd6d3cb0722f549b8a9c8f06feba3165dfd421c4ce0658b75b90a6e64e84a4b"} [k2-p42268593] Two Years of Menaquinone-7 Supplementation and Coronary Artery Calcification: A Randomized Clinical Trial. (2026). https://pubmed.ncbi.nlm.nih.gov/42268593/ DOI: 10.1001/jamacardio.2026.1279
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.