Component
Colorectal cancer incidence
Colorectal cancer incidence. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
No colorectal cancers were detected during follow-up in either trial group.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/berberine-research/31926918.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0045a39cfd796c9db7aa81e0a9c4bea8004396e137d842519e03664560c4878c", "start_char": 0, "end_char": 2466, "text_sha256": "0045a39cfd796c9db7aa81e0a9c4bea8004396e137d842519e03664560c4878c"}
- experimental_model
- Multicenter double-blind randomized placebo-controlled trial
- exposure
- Berberine 0.3 g twice daily; colonoscopy follow-up up to two years
- limitations
- Modified intention-to-treat analysis excluded participants without efficacy data. Adenoma recurrence is not colorectal-cancer mortality or proof of cancer treatment.
- nutrient_topic
- Berberine research collection; topical membership is not evidence of a direct dietary effect. · Berberine
- organism
- Adults after colorectal polypectomy; 1108 randomized, 891 in full analysis
- plain_language
- Zero observed cancers do not establish a cancer-prevention effect.
- primary_references
- [berberine-p31926918] Berberine versus placebo for the prevention of recurrence of colorectal adenoma: a multicentre, double-blinded, randomised controlled study. (2020). https://pubmed.ncbi.nlm.nih.gov/31926918/ DOI: 10.1016/s2468-1253(19)30409-1
- tissue_or_cell_type
- Adenoma recurrence
Berberine: metabolism, nutrient connections and drug interactions (2026-09-17) · lines 1312–1323
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Multicenter double-blind randomized placebo-controlled trial · source_derived_draft · unverified_draft
### berberine-adenoma-cancer-null No colorectal cancers were detected during follow-up in either trial group. Condition category: normal nutrient_topic: Berberine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Zero observed cancers do not establish a cancer-prevention effect. organism: Adults after colorectal polypectomy; 1108 randomized, 891 in full analysis tissue_or_cell_type: Adenoma recurrence experimental_model: Multicenter double-blind randomized placebo-controlled trial limitations: Modified intention-to-treat analysis excluded participants without efficacy data. Adenoma recurrence is not colorectal-cancer mortality or proof of cancer treatment. exposure: Berberine 0.3 g twice daily; colonoscopy follow-up up to two years evidence_span: {"source_cache": "artifacts/berberine-research/31926918.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0045a39cfd796c9db7aa81e0a9c4bea8004396e137d842519e03664560c4878c", "start_char": 0, "end_char": 2466, "text_sha256": "0045a39cfd796c9db7aa81e0a9c4bea8004396e137d842519e03664560c4878c"} [berberine-p31926918] Berberine versus placebo for the prevention of recurrence of colorectal adenoma: a multicentre, double-blinded, randomised controlled study. (2020). https://pubmed.ncbi.nlm.nih.gov/31926918/ DOI: 10.1016/s2468-1253(19)30409-1
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.