{"id":"9114fc55-1787-53ea-be93-226002f0cfd5","stable_key":"7484635e-cc8f-5cd6-a978-6dc5775a7db5:berberine-adenoma-cancer-null","predicate":"cancer_benefit_not_estimable_from_zero_events_in","statement":"No colorectal cancers were detected during follow-up in either trial group.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d94cd348-89be-5950-b0ae-1b69b96fc606","mechanism_event_label":"Zero observed cancers do not establish a cancer-prevention effect.","subject":{"id":"7bbe0633-b2f1-510f-adc0-3c4d0ddad05d","slug":"berberine","display_name":"Berberine","entity_type_key":"small_molecule"},"object":{"id":"36855e0b-82e3-53ac-a63b-96955476c9cc","slug":"colorectal-cancer-incidence","display_name":"Colorectal cancer incidence","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d94cd348-89be-5950-b0ae-1b69b96fc606","stable_key":"7484635e-cc8f-5cd6-a978-6dc5775a7db5:berberine-adenoma-cancer-null-event","event_type":"observed_intervention","label":"Zero observed cancers do not establish a cancer-prevention effect.","description":"No colorectal cancers were detected during follow-up in either trial group.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"7bbe0633-b2f1-510f-adc0-3c4d0ddad05d","slug":"berberine","display_name":"Berberine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"36855e0b-82e3-53ac-a63b-96955476c9cc","slug":"colorectal-cancer-incidence","display_name":"Colorectal cancer incidence","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/berberine-research/31926918.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0045a39cfd796c9db7aa81e0a9c4bea8004396e137d842519e03664560c4878c\", \"start_char\": 0, \"end_char\": 2466, \"text_sha256\": \"0045a39cfd796c9db7aa81e0a9c4bea8004396e137d842519e03664560c4878c\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Multicenter double-blind randomized placebo-controlled trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Berberine 0.3 g twice daily; colonoscopy follow-up up to two years","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Modified intention-to-treat analysis excluded participants without efficacy data. Adenoma recurrence is not colorectal-cancer mortality or proof of cancer treatment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Berberine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"berberine","display_name":"Berberine","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Adults after colorectal polypectomy; 1108 randomized, 891 in full analysis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Zero observed cancers do not establish a cancer-prevention effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[berberine-p31926918] Berberine versus placebo for the prevention of recurrence of colorectal adenoma: a multicentre, double-blinded, randomised controlled study. (2020). https://pubmed.ncbi.nlm.nih.gov/31926918/ DOI: 10.1016/s2468-1253(19)30409-1","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Adenoma recurrence","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0a88a7ae-3d57-5843-99c5-b8ff781c07d2","evidence_kind":"source_excerpt","locator":"Lines 1312-1323","start_line":1312,"end_line":1323,"excerpt":"### berberine-adenoma-cancer-null\nNo colorectal cancers were detected during follow-up in either trial group.\nCondition category: normal\nnutrient_topic: Berberine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Zero observed cancers do not establish a cancer-prevention effect.\norganism: Adults after colorectal polypectomy; 1108 randomized, 891 in full analysis\ntissue_or_cell_type: Adenoma recurrence\nexperimental_model: Multicenter double-blind randomized placebo-controlled trial\nlimitations: Modified intention-to-treat analysis excluded participants without efficacy data. Adenoma recurrence is not colorectal-cancer mortality or proof of cancer treatment.\nexposure: Berberine 0.3 g twice daily; colonoscopy follow-up up to two years\nevidence_span: {\"source_cache\": \"artifacts/berberine-research/31926918.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0045a39cfd796c9db7aa81e0a9c4bea8004396e137d842519e03664560c4878c\", \"start_char\": 0, \"end_char\": 2466, \"text_sha256\": \"0045a39cfd796c9db7aa81e0a9c4bea8004396e137d842519e03664560c4878c\"}\n[berberine-p31926918] Berberine versus placebo for the prevention of recurrence of colorectal adenoma: a multicentre, double-blinded, randomised controlled study. (2020). https://pubmed.ncbi.nlm.nih.gov/31926918/ DOI: 10.1016/s2468-1253(19)30409-1","model_system":"Multicenter double-blind randomized placebo-controlled trial","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [berberine-p31926918] Berberine versus placebo for the prevention of recurrence of colorectal adenoma: a multicentre, double-blinded, randomised controlled study. (2020). https://pubmed.ncbi.nlm.nih.gov/31926918/ DOI: 10.1016/s2468-1253(19)30409-1","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"9bb61e1d-e5cf-5b05-a9ca-409291f7a313","stable_key":"import-7484635e-cc8f-5cd6-a978-6dc5775a7db5","title":"Berberine: metabolism, nutrient connections and drug interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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