Component
DNA damage in HT-29 and HCT-116 cells
DNA damage in HT-29 and HCT-116 cells. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Nasunin and its deacylated derivatives protected against DNA damage in a dose-dependent manner.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/nasunin-research/25442541.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "14f1cfb323570e36200958bb6acb4c083621b7b02ebda1e793d133b3ea95b1c7", "start_char": 0, "end_char": 1299, "text_sha256": "14f1cfb323570e36200958bb6acb4c083621b7b02ebda1e793d133b3ea95b1c7"}
- experimental_model
- Comparative anthocyanin exposure in cultured colon cancer lines
- exposure
- Nasunin and differently glycosylated delphinidin derivatives; quantitative regimens not specified in indexed abstract
- limitations
- Primary experiments are described despite an additional Review index tag. Protein association does not establish GSR-mediated causality; these are cancer cells, not normal colon tissue or patients.
- nutrient_topic
- Nasunin research collection; topical membership is not evidence of a direct dietary effect. · Nasunin
- organism
- Human HT-29 and HCT-116 cells
- plain_language
- A weaker ROS assay result did not eliminate the separate DNA-protection finding.
- primary_references
- [nasunin-p25442541] Effect of glycosylation patterns of Chinese eggplant anthocyanins and other derivatives on antioxidant effectiveness in human colon cell lines. (2015). https://pubmed.ncbi.nlm.nih.gov/25442541/ DOI: 10.1016/j.foodchem.2014.08.100
- tissue_or_cell_type
- ROS, glutathione reductase protein and DNA damage
Nasunin: identity, redox chemistry and nutrient connections (2026-09-17) · lines 705–716
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Comparative anthocyanin exposure in cultured colon cancer lines · source_derived_draft · unverified_draft
### nasunin-colon-dna-protection Nasunin and its deacylated derivatives protected against DNA damage in a dose-dependent manner. Condition category: normal nutrient_topic: Nasunin research collection; topical membership is not evidence of a direct dietary effect. plain_language: A weaker ROS assay result did not eliminate the separate DNA-protection finding. organism: Human HT-29 and HCT-116 cells tissue_or_cell_type: ROS, glutathione reductase protein and DNA damage experimental_model: Comparative anthocyanin exposure in cultured colon cancer lines limitations: Primary experiments are described despite an additional Review index tag. Protein association does not establish GSR-mediated causality; these are cancer cells, not normal colon tissue or patients. exposure: Nasunin and differently glycosylated delphinidin derivatives; quantitative regimens not specified in indexed abstract evidence_span: {"source_cache": "artifacts/nasunin-research/25442541.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "14f1cfb323570e36200958bb6acb4c083621b7b02ebda1e793d133b3ea95b1c7", "start_char": 0, "end_char": 1299, "text_sha256": "14f1cfb323570e36200958bb6acb4c083621b7b02ebda1e793d133b3ea95b1c7"} [nasunin-p25442541] Effect of glycosylation patterns of Chinese eggplant anthocyanins and other derivatives on antioxidant effectiveness in human colon cell lines. (2015). https://pubmed.ncbi.nlm.nih.gov/25442541/ DOI: 10.1016/j.foodchem.2014.08.100
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.