Component
COBRIT global functional/cognitive outcome at 90 days
COBRIT global functional/cognitive outcome at 90 days. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The 90-day global functional/cognitive outcome did not differ significantly with citicoline: odds ratio 0.98, 95% CI 0.83–1.15.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/choline-research/23168823.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "57ad3435837e866a92fad1e25c19d9a4919f522026731b48ba7df3b345664186", "start_char": 0, "end_char": 2347, "text_sha256": "57ad3435837e866a92fad1e25c19d9a4919f522026731b48ba7df3b345664186"}
- experimental_model
- COBRIT phase 3 randomized double-blind placebo-controlled trial
- exposure
- Citicoline 2000 mg/day enteral/oral for 90 days
- limitations
- Drug-form intervention after brain injury, not correction of documented dietary choline deficiency.
- nutrient_topic
- Choline research collection; topical membership is not evidence of a direct dietary effect. · Choline
- organism
- Human
- plain_language
- A plausible biochemical precursor did not improve this clinical trial’s outcome.
- primary_references
- [choline-p23168823] Effect of citicoline on functional and cognitive status among patients with traumatic brain injury: Citicoline Brain Injury Treatment Trial (COBRIT). (2012). https://pubmed.ncbi.nlm.nih.gov/23168823/ DOI: 10.1001/jama.2012.13256
- tissue_or_cell_type
- 1213 people with complicated mild, moderate or severe traumatic brain injury
Choline: metabolism, signaling and nutrient connections (2026-09-17) · lines 1322–1333
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · COBRIT phase 3 randomized double-blind placebo-controlled trial · source_derived_draft · unverified_draft
### choline-citicoline-tbi-null The 90-day global functional/cognitive outcome did not differ significantly with citicoline: odds ratio 0.98, 95% CI 0.83–1.15. Condition category: normal nutrient_topic: Choline research collection; topical membership is not evidence of a direct dietary effect. plain_language: A plausible biochemical precursor did not improve this clinical trial’s outcome. organism: Human tissue_or_cell_type: 1213 people with complicated mild, moderate or severe traumatic brain injury experimental_model: COBRIT phase 3 randomized double-blind placebo-controlled trial limitations: Drug-form intervention after brain injury, not correction of documented dietary choline deficiency. exposure: Citicoline 2000 mg/day enteral/oral for 90 days evidence_span: {"source_cache": "artifacts/choline-research/23168823.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "57ad3435837e866a92fad1e25c19d9a4919f522026731b48ba7df3b345664186", "start_char": 0, "end_char": 2347, "text_sha256": "57ad3435837e866a92fad1e25c19d9a4919f522026731b48ba7df3b345664186"} [choline-p23168823] Effect of citicoline on functional and cognitive status among patients with traumatic brain injury: Citicoline Brain Injury Treatment Trial (COBRIT). (2012). https://pubmed.ncbi.nlm.nih.gov/23168823/ DOI: 10.1001/jama.2012.13256
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.