{"id":"9aebda29-bbfc-5461-b6de-9a995193ac48","stable_key":"27e0c1cf-7726-5164-8b15-27a631584cd0:choline-citicoline-tbi-null","predicate":"has_no_significant_effect","statement":"The 90-day global functional/cognitive outcome did not differ significantly with citicoline: odds ratio 0.98, 95% CI 0.83–1.15.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"3af94002-17ee-51c6-a723-d88d44b3f836","mechanism_event_label":"A plausible biochemical precursor did not improve this clinical trial’s outcome.","subject":{"id":"a3f7d46d-ea2d-5cd0-a5f4-d1091a53f99c","slug":"citicoline-trial-intervention","display_name":"Citicoline treatment in the COBRIT and ICTUS trials","entity_type_key":"chemical_species"},"object":{"id":"739076f6-f449-51a6-83ee-e55ca1bad016","slug":"cobrit-global-outcome","display_name":"COBRIT global functional/cognitive outcome at 90 days","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"3af94002-17ee-51c6-a723-d88d44b3f836","stable_key":"27e0c1cf-7726-5164-8b15-27a631584cd0:choline-citicoline-tbi-null-event","event_type":"observed_intervention","label":"A plausible biochemical precursor did not improve this clinical trial’s outcome.","description":"The 90-day global functional/cognitive outcome did not differ significantly with citicoline: odds ratio 0.98, 95% CI 0.83–1.15.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e1f22bfd-771d-5405-b2d4-ff5f4ae4d95f","slug":"cdp-choline","display_name":"CDP-choline","entity_type_key":"small_molecule"},"role":"active_molecular_identity","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a3f7d46d-ea2d-5cd0-a5f4-d1091a53f99c","slug":"citicoline-trial-intervention","display_name":"Citicoline treatment in the COBRIT and ICTUS trials","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"739076f6-f449-51a6-83ee-e55ca1bad016","slug":"cobrit-global-outcome","display_name":"COBRIT global functional/cognitive outcome at 90 days","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/choline-research/23168823.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"57ad3435837e866a92fad1e25c19d9a4919f522026731b48ba7df3b345664186\", \"start_char\": 0, \"end_char\": 2347, \"text_sha256\": \"57ad3435837e866a92fad1e25c19d9a4919f522026731b48ba7df3b345664186\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"COBRIT phase 3 randomized double-blind placebo-controlled trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Citicoline 2000 mg/day enteral/oral for 90 days","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Drug-form intervention after brain injury, not correction of documented dietary choline deficiency.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Choline research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"choline","display_name":"Choline","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A plausible biochemical precursor did not improve this clinical trial’s outcome.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[choline-p23168823] Effect of citicoline on functional and cognitive status among patients with traumatic brain injury: Citicoline Brain Injury Treatment Trial (COBRIT). (2012). https://pubmed.ncbi.nlm.nih.gov/23168823/ DOI: 10.1001/jama.2012.13256","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"1213 people with complicated mild, moderate or severe traumatic brain injury","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"05e8a510-d5e4-5d26-b544-18a6291c978b","evidence_kind":"source_excerpt","locator":"Lines 1322-1333","start_line":1322,"end_line":1333,"excerpt":"### choline-citicoline-tbi-null\nThe 90-day global functional/cognitive outcome did not differ significantly with citicoline: odds ratio 0.98, 95% CI 0.83–1.15.\nCondition category: normal\nnutrient_topic: Choline research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A plausible biochemical precursor did not improve this clinical trial’s outcome.\norganism: Human\ntissue_or_cell_type: 1213 people with complicated mild, moderate or severe traumatic brain injury\nexperimental_model: COBRIT phase 3 randomized double-blind placebo-controlled trial\nlimitations: Drug-form intervention after brain injury, not correction of documented dietary choline deficiency.\nexposure: Citicoline 2000 mg/day enteral/oral for 90 days\nevidence_span: {\"source_cache\": \"artifacts/choline-research/23168823.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"57ad3435837e866a92fad1e25c19d9a4919f522026731b48ba7df3b345664186\", \"start_char\": 0, \"end_char\": 2347, \"text_sha256\": \"57ad3435837e866a92fad1e25c19d9a4919f522026731b48ba7df3b345664186\"}\n[choline-p23168823] Effect of citicoline on functional and cognitive status among patients with traumatic brain injury: Citicoline Brain Injury Treatment Trial (COBRIT). (2012). https://pubmed.ncbi.nlm.nih.gov/23168823/ DOI: 10.1001/jama.2012.13256","model_system":"COBRIT phase 3 randomized double-blind placebo-controlled trial","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [choline-p23168823] Effect of citicoline on functional and cognitive status among patients with traumatic brain injury: Citicoline Brain Injury Treatment Trial (COBRIT). (2012). https://pubmed.ncbi.nlm.nih.gov/23168823/ DOI: 10.1001/jama.2012.13256","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"0ba2f05e-5cf5-5bd7-ae5d-0ab4945fcb7b","stable_key":"import-27e0c1cf-7726-5164-8b15-27a631584cd0","title":"Choline: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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