Component

Central nervous system oxygen toxicity seizure

Central nervous system oxygen toxicity seizure. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. The NMDA receptor inhibitor MK-801 did not alter the cerebrovascular responses to oxygen at 5 ATA but prevented the electroencephalographic spikes.

    Hyperbaric oxygen therapy → Central nervous system oxygen toxicity seizure source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/hbot-research/10749833.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1470d09e77b6d6f6af3131a6f7db2cca647dde3655662a1c83f9d5d375f1c687", "start_char": 0, "end_char": 1283, "text_sha256": "1470d09e77b6d6f6af3131a6f7db2cca647dde3655662a1c83f9d5d375f1c687"}
    experimental_model
    Regional cerebral blood flow and electroencephalography in anaesthetised rats
    exposure
    Oxygen at 1, 3, 4 and 5 ATA with L-NAME, L-arginine, nitric oxide donors or MK-801
    limitations
    A time-course study at toxic pressures. It shows the nitric oxide effect reverses with exposure time, which a single time point would miss.
    nutrient_topic
    Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Hyperbaric oxygen therapy
    organism
    Rat
    plain_language
    The seizure and the blood-flow change are separate events with separate causes.
    primary_references
    [hbot-p10749833] Nitric oxide and cerebral blood flow responses to hyperbaric oxygen. (2000). https://pubmed.ncbi.nlm.nih.gov/10749833/ DOI: 10.1152/jappl.2000.88.4.1381
    tissue_or_cell_type
    Brain

    Hyperbaric oxygen: the exposure, its reactive species, the signals they carry, and the nutrient-dependent enzymes that handle them (2026-09-19) · lines 218–229

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Regional cerebral blood flow and electroencephalography in anaesthetised rats · source_derived_draft · unverified_draft

    ### hbot-seizure-glutamate-independent-flow The NMDA receptor inhibitor MK-801 did not alter the cerebrovascular responses to oxygen at 5 ATA but prevented the electroencephalographic spikes. Condition category: normal nutrient_topic: Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: The seizure and the blood-flow change are separate events with separate causes. organism: Rat tissue_or_cell_type: Brain experimental_model: Regional cerebral blood flow and electroencephalography in anaesthetised rats limitations: A time-course study at toxic pressures. It shows the nitric oxide effect reverses with exposure time, which a single time point would miss. exposure: Oxygen at 1, 3, 4 and 5 ATA with L-NAME, L-arginine, nitric oxide donors or MK-801 evidence_span: {"source_cache": "artifacts/hbot-research/10749833.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1470d09e77b6d6f6af3131a6f7db2cca647dde3655662a1c83f9d5d375f1c687", "start_char": 0, "end_char": 1283, "text_sha256": "1470d09e77b6d6f6af3131a6f7db2cca647dde3655662a1c83f9d5d375f1c687"} [hbot-p10749833] Nitric oxide and cerebral blood flow responses to hyperbaric oxygen. (2000). https://pubmed.ncbi.nlm.nih.gov/10749833/ DOI: 10.1152/jappl.2000.88.4.1381
    Complete structured claim and evidence

  2. Two seizures were documented in 80,679 patient-treatments, an incidence of 2.4 per 100,000 patient-treatments, both in a multiplace chamber at 2.4 ATA with oxygen by mask.

    Hyperbaric oxygen therapy → Central nervous system oxygen toxicity seizure source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/hbot-research/15559001.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "5507526d06e294cc1dfe4ce0be912be957c850b3d7e8243c7fd947c5a10c2c82", "start_char": 0, "end_char": 1303, "text_sha256": "5507526d06e294cc1dfe4ce0be912be957c850b3d7e8243c7fd947c5a10c2c82"}
    experimental_model
    Retrospective review of 80,679 patient-treatments in two university hyperbaric departments
    exposure
    Routine hyperbaric oxygen protocols, including 2.4 ATA by mask with air breaks
    limitations
    A retrospective incidence count. It describes risk under appropriate exclusion criteria and treatment profiles, and does not estimate risk for an individual.
    nutrient_topic
    Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Hyperbaric oxygen therapy
    organism
    Human
    plain_language
    The feared brain side effect happened about twice in eighty thousand treatments.
    primary_references
    [hbot-p15559001] Seizure incidence in 80,000 patient treatments with hyperbaric oxygen. (2004). https://pubmed.ncbi.nlm.nih.gov/15559001/
    tissue_or_cell_type
    Central nervous system

    Hyperbaric oxygen: the exposure, its reactive species, the signals they carry, and the nutrient-dependent enzymes that handle them (2026-09-19) · lines 140–151

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Retrospective review of 80,679 patient-treatments in two university hyperbaric departments · source_derived_draft · unverified_draft

    ### hbot-seizure-incidence Two seizures were documented in 80,679 patient-treatments, an incidence of 2.4 per 100,000 patient-treatments, both in a multiplace chamber at 2.4 ATA with oxygen by mask. Condition category: normal nutrient_topic: Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: The feared brain side effect happened about twice in eighty thousand treatments. organism: Human tissue_or_cell_type: Central nervous system experimental_model: Retrospective review of 80,679 patient-treatments in two university hyperbaric departments limitations: A retrospective incidence count. It describes risk under appropriate exclusion criteria and treatment profiles, and does not estimate risk for an individual. exposure: Routine hyperbaric oxygen protocols, including 2.4 ATA by mask with air breaks evidence_span: {"source_cache": "artifacts/hbot-research/15559001.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "5507526d06e294cc1dfe4ce0be912be957c850b3d7e8243c7fd947c5a10c2c82", "start_char": 0, "end_char": 1303, "text_sha256": "5507526d06e294cc1dfe4ce0be912be957c850b3d7e8243c7fd947c5a10c2c82"} [hbot-p15559001] Seizure incidence in 80,000 patient treatments with hyperbaric oxygen. (2004). https://pubmed.ncbi.nlm.nih.gov/15559001/
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Blood flow fell by 26 to 43% at 3 and 4 ATA, but at 5 ATA it fell over 30 minutes then gradually returned to pre-exposure levels, preceding the onset of electroencephalographic spiking.

    Hyperbaric oxygen therapy → Regional cerebral blood flow source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/hbot-research/10749833.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1470d09e77b6d6f6af3131a6f7db2cca647dde3655662a1c83f9d5d375f1c687", "start_char": 0, "end_char": 1283, "text_sha256": "1470d09e77b6d6f6af3131a6f7db2cca647dde3655662a1c83f9d5d375f1c687"}
    experimental_model
    Regional cerebral blood flow and electroencephalography in anaesthetised rats
    exposure
    Oxygen at 1, 3, 4 and 5 ATA with L-NAME, L-arginine, nitric oxide donors or MK-801
    limitations
    A time-course study at toxic pressures. It shows the nitric oxide effect reverses with exposure time, which a single time point would miss.
    nutrient_topic
    Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Hyperbaric oxygen therapy
    organism
    Rat
    plain_language
    The vessel response flips during a long exposure, and the flip comes just before the seizure activity.
    primary_references
    [hbot-p10749833] Nitric oxide and cerebral blood flow responses to hyperbaric oxygen. (2000). https://pubmed.ncbi.nlm.nih.gov/10749833/ DOI: 10.1152/jappl.2000.88.4.1381
    tissue_or_cell_type
    Brain

    Hyperbaric oxygen: the exposure, its reactive species, the signals they carry, and the nutrient-dependent enzymes that handle them (2026-09-19) · lines 192–203

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Regional cerebral blood flow and electroencephalography in anaesthetised rats · source_derived_draft · unverified_draft

    ### hbot-cbf-time-course Blood flow fell by 26 to 43% at 3 and 4 ATA, but at 5 ATA it fell over 30 minutes then gradually returned to pre-exposure levels, preceding the onset of electroencephalographic spiking. Condition category: normal nutrient_topic: Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: The vessel response flips during a long exposure, and the flip comes just before the seizure activity. organism: Rat tissue_or_cell_type: Brain experimental_model: Regional cerebral blood flow and electroencephalography in anaesthetised rats limitations: A time-course study at toxic pressures. It shows the nitric oxide effect reverses with exposure time, which a single time point would miss. exposure: Oxygen at 1, 3, 4 and 5 ATA with L-NAME, L-arginine, nitric oxide donors or MK-801 evidence_span: {"source_cache": "artifacts/hbot-research/10749833.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1470d09e77b6d6f6af3131a6f7db2cca647dde3655662a1c83f9d5d375f1c687", "start_char": 0, "end_char": 1283, "text_sha256": "1470d09e77b6d6f6af3131a6f7db2cca647dde3655662a1c83f9d5d375f1c687"} [hbot-p10749833] Nitric oxide and cerebral blood flow responses to hyperbaric oxygen. (2000). https://pubmed.ncbi.nlm.nih.gov/10749833/ DOI: 10.1152/jappl.2000.88.4.1381
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards