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It shows the nitric oxide effect reverses with exposure time, which a single time point would miss.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake.","comparator":null,"unit":null,"notes":"","entity":{"slug":"hyperbaric-oxygen","display_name":"Hyperbaric oxygen therapy","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Rat","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The seizure and the blood-flow change are separate events with separate causes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[hbot-p10749833] Nitric oxide and cerebral blood flow responses to hyperbaric oxygen. (2000). https://pubmed.ncbi.nlm.nih.gov/10749833/ DOI: 10.1152/jappl.2000.88.4.1381","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Brain","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"09ff8b4c-4cd4-59cb-8349-c5338b09b407","evidence_kind":"source_excerpt","locator":"Lines 218-229","start_line":218,"end_line":229,"excerpt":"### hbot-seizure-glutamate-independent-flow\nThe NMDA receptor inhibitor MK-801 did not alter the cerebrovascular responses to oxygen at 5 ATA but prevented the electroencephalographic spikes.\nCondition category: normal\nnutrient_topic: Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake.\nplain_language: The seizure and the blood-flow change are separate events with separate causes.\norganism: Rat\ntissue_or_cell_type: Brain\nexperimental_model: Regional cerebral blood flow and electroencephalography in anaesthetised rats\nlimitations: A time-course study at toxic pressures. It shows the nitric oxide effect reverses with exposure time, which a single time point would miss.\nexposure: Oxygen at 1, 3, 4 and 5 ATA with L-NAME, L-arginine, nitric oxide donors or MK-801\nevidence_span: {\"source_cache\": \"artifacts/hbot-research/10749833.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"1470d09e77b6d6f6af3131a6f7db2cca647dde3655662a1c83f9d5d375f1c687\", \"start_char\": 0, \"end_char\": 1283, \"text_sha256\": \"1470d09e77b6d6f6af3131a6f7db2cca647dde3655662a1c83f9d5d375f1c687\"}\n[hbot-p10749833] Nitric oxide and cerebral blood flow responses to hyperbaric oxygen. (2000). https://pubmed.ncbi.nlm.nih.gov/10749833/ DOI: 10.1152/jappl.2000.88.4.1381","model_system":"Regional cerebral blood flow and electroencephalography in anaesthetised rats","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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