Component
Circulating erythropoietin concentration
Independent biological entity. Read linked claims for experimental scope and context.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Male Gulo-null mice deprived of vitamin C for approximately five weeks retained a robust plasma erythropoietin response to 24 h at 8% oxygen, similar to supplemented controls, despite plasma ascorbate at or below 1 µM and scorbutic weight loss.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- cross_nutrient
- false
- evidence_location
- Figure 5C–D; Animal studies
- experimental_model
- Dietary withdrawal in adult male Gulo-null mice with supplemented-genotype controls
- exposure
- Maintenance 0.33 g/L ascorbic acid drinking water; withdrawal about 35–36 days; 8% inspired oxygen for 24 h.
- limitations
- Dietary deficiency in a synthesis-null animal; does not establish that every HIF target or tissue is unaffected, nor a safe human deficiency threshold.
- nutrient_topic
- Vitamin C research collection; topical membership is not evidence of a direct dietary effect. · Vitamin C
- organism
- Mus musculus
- plain_language
- Even severely vitamin-C-depleted mice retained this measured hormonal response to low oxygen.
- primary_references
- [c-reg-nytko] Vitamin C is dispensable for oxygen sensing in vivo. (2011). https://pubmed.ncbi.nlm.nih.gov/21346252/ DOI: 10.1182/blood-2010-09-307637
- tissue_or_cell_type
- Plasma erythropoietin; kidney Epo mRNA supporting endpoint
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1187–1199
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Dietary withdrawal in adult male Gulo-null mice with supplemented-genotype controls · source_derived_draft · unverified_draft
### c-reg-gulo-depletion-epo-preserved Male Gulo-null mice deprived of vitamin C for approximately five weeks retained a robust plasma erythropoietin response to 24 h at 8% oxygen, similar to supplemented controls, despite plasma ascorbate at or below 1 µM and scorbutic weight loss. Condition category: nutrient_deficiency nutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect. plain_language: Even severely vitamin-C-depleted mice retained this measured hormonal response to low oxygen. organism: Mus musculus tissue_or_cell_type: Plasma erythropoietin; kidney Epo mRNA supporting endpoint experimental_model: Dietary withdrawal in adult male Gulo-null mice with supplemented-genotype controls limitations: Dietary deficiency in a synthesis-null animal; does not establish that every HIF target or tissue is unaffected, nor a safe human deficiency threshold. exposure: Maintenance 0.33 g/L ascorbic acid drinking water; withdrawal about 35–36 days; 8% inspired oxygen for 24 h. cross_nutrient: false evidence_location: Figure 5C–D; Animal studies [c-reg-nytko] Vitamin C is dispensable for oxygen sensing in vivo. (2011). https://pubmed.ncbi.nlm.nih.gov/21346252/ DOI: 10.1182/blood-2010-09-307637
Complete structured claim and evidenceVitamin A increased circulating EPO and hemoglobin in schoolchildren with poor nutrient status.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- cross_nutrient
- Vitamin A -> EPO/iron use.
- experimental_model
- Randomized ten-month follow-up.
- limitations
- EPO was measured, not blocked; its mediation of the hemoglobin response remains inferred.
- nutrient_topic
- Vitamin A research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
- organism
- Homo sapiens
- plain_language
- Vitamin A can influence the signal that supports red-cell production.
- primary_references
- [va-zimmermann2006-iron] Vitamin A supplementation in children with poor vitamin A and iron status increases erythropoietin and hemoglobin concentrations without changing total body iron (2006). https://pubmed.ncbi.nlm.nih.gov/16960172/ DOI: 10.1093/ajcn/84.3.580
- tissue_or_cell_type
- Blood
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17) · lines 1460–1470
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized ten-month follow-up. · source_derived_draft · unverified_draft
### va-repletion-erythropoietin Vitamin A increased circulating EPO and hemoglobin in schoolchildren with poor nutrient status. Condition category: nutrient_deficiency nutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect. plain_language: Vitamin A can influence the signal that supports red-cell production. organism: Homo sapiens tissue_or_cell_type: Blood experimental_model: Randomized ten-month follow-up. limitations: EPO was measured, not blocked; its mediation of the hemoglobin response remains inferred. cross_nutrient: Vitamin A -> EPO/iron use. [va-zimmermann2006-iron] Vitamin A supplementation in children with poor vitamin A and iron status increases erythropoietin and hemoglobin concentrations without changing total body iron (2006). https://pubmed.ncbi.nlm.nih.gov/16960172/ DOI: 10.1093/ajcn/84.3.580
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.