{"id":"e08ddc37-6e66-5cbf-a579-bd03031d3c21","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-repletion-erythropoietin","predicate":"supplementation_increases","statement":"Vitamin A increased circulating EPO and hemoglobin in schoolchildren with poor nutrient status.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"6455ddaf-c704-52cb-a572-d37e84e65681","mechanism_event_label":"Vitamin A can influence the signal that supports red-cell production.","subject":{"id":"ce392c9e-6483-5914-b18b-d6a2520dbbf6","slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"},"object":{"id":"5edaae24-82b7-570f-9510-0aba98ebde06","slug":"circulating-erythropoietin","display_name":"Circulating erythropoietin concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6455ddaf-c704-52cb-a572-d37e84e65681","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-repletion-erythropoietin-event","event_type":"observed_intervention","label":"Vitamin A can influence the signal that supports red-cell production.","description":"Vitamin A increased circulating EPO and hemoglobin in schoolchildren with poor nutrient status.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"47ad89a2-2a43-51b7-8af4-f415f606b5b6","slug":"epo","display_name":"Erythropoietin","entity_type_key":"protein"},"role":"measured_hormone","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"role":"nutrient_context","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2f3a8d0b-7b92-58d2-afc9-dd26a7cd1e0e","slug":"blood-hemoglobin-concentration","display_name":"Blood hemoglobin concentration","entity_type_key":"cellular_process"},"role":"parallel_endpoint","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"ce392c9e-6483-5914-b18b-d6a2520dbbf6","slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"5edaae24-82b7-570f-9510-0aba98ebde06","slug":"circulating-erythropoietin","display_name":"Circulating erythropoietin concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"Vitamin A -> EPO/iron use.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized ten-month follow-up.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"EPO was measured, not blocked; its mediation of the hemoglobin response remains inferred.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin A research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Vitamin A can influence the signal that supports red-cell production.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[va-zimmermann2006-iron] Vitamin A supplementation in children with poor vitamin A and iron status increases erythropoietin and hemoglobin concentrations without changing total body iron (2006). https://pubmed.ncbi.nlm.nih.gov/16960172/ DOI: 10.1093/ajcn/84.3.580","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Blood","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"5077cf97-7f25-5a76-b71b-1ca351837de0","evidence_kind":"source_excerpt","locator":"Lines 1460-1470","start_line":1460,"end_line":1470,"excerpt":"### va-repletion-erythropoietin\nVitamin A increased circulating EPO and hemoglobin in schoolchildren with poor nutrient status.\nCondition category: nutrient_deficiency\nnutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Vitamin A can influence the signal that supports red-cell production.\norganism: Homo sapiens\ntissue_or_cell_type: Blood\nexperimental_model: Randomized ten-month follow-up.\nlimitations: EPO was measured, not blocked; its mediation of the hemoglobin response remains inferred.\ncross_nutrient: Vitamin A -> EPO/iron use.\n[va-zimmermann2006-iron] Vitamin A supplementation in children with poor vitamin A and iron status increases erythropoietin and hemoglobin concentrations without changing total body iron (2006). https://pubmed.ncbi.nlm.nih.gov/16960172/ DOI: 10.1093/ajcn/84.3.580","model_system":"Randomized ten-month follow-up.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [va-zimmermann2006-iron] Vitamin A supplementation in children with poor vitamin A and iron status increases erythropoietin and hemoglobin concentrations without changing total body iron (2006). https://pubmed.ncbi.nlm.nih.gov/16960172/ DOI: 10.1093/ajcn/84.3.580","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"0c5474e2-be48-547b-b287-9c07a59c9ff1","stable_key":"import-dff9f743-3766-5f20-a71e-d6d2bd5bfb6f","title":"Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b217224b262abbd77d6a0c8c9beefff9c022fae4d31e2a5273915d769b9a6546","revision_id":"61008909-871f-575c-b5e2-21542689ea3c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}