Component

Circulating CD34-positive stem and progenitor cells

Circulating CD34-positive stem and progenitor cells. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. CD34-positive cells in human peripheral blood doubled after a single 2.0 ATA exposure and rose eightfold over 20 treatments, without a significant increase in the overall white cell count.

    Hyperbaric oxygen therapy → Circulating CD34-positive stem and progenitor cells source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/hbot-research/16299259.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "76c0554557a30ac9a32f25b74b27edb5f8f8a57ee0c0660dfe5619b78732c730", "start_char": 0, "end_char": 1502, "text_sha256": "76c0554557a30ac9a32f25b74b27edb5f8f8a57ee0c0660dfe5619b78732c730"}
    experimental_model
    Human volunteers, mice, and endothelial nitric oxide synthase knockout mice
    exposure
    2.0 atmospheres absolute oxygen for 2 hours, single and over 20 treatments
    limitations
    The knockout and inhibitor arms carry the causal claim. Progenitor phenotype is defined by surface markers and colony formation, not by a demonstrated contribution to a healed vessel.
    nutrient_topic
    Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Hyperbaric oxygen therapy
    organism
    Human and mouse
    plain_language
    The therapy calls stem cells out of the marrow into the blood.
    primary_references
    [hbot-p16299259] Stem cell mobilization by hyperbaric oxygen. (2006). https://pubmed.ncbi.nlm.nih.gov/16299259/ DOI: 10.1152/ajpheart.00888.2005
    tissue_or_cell_type
    Bone marrow and peripheral blood

    Hyperbaric oxygen: the exposure, its reactive species, the signals they carry, and the nutrient-dependent enzymes that handle them (2026-09-19) · lines 530–541

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human volunteers, mice, and endothelial nitric oxide synthase knockout mice · source_derived_draft · unverified_draft

    ### hbot-cd34-mobilisation CD34-positive cells in human peripheral blood doubled after a single 2.0 ATA exposure and rose eightfold over 20 treatments, without a significant increase in the overall white cell count. Condition category: normal nutrient_topic: Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: The therapy calls stem cells out of the marrow into the blood. organism: Human and mouse tissue_or_cell_type: Bone marrow and peripheral blood experimental_model: Human volunteers, mice, and endothelial nitric oxide synthase knockout mice limitations: The knockout and inhibitor arms carry the causal claim. Progenitor phenotype is defined by surface markers and colony formation, not by a demonstrated contribution to a healed vessel. exposure: 2.0 atmospheres absolute oxygen for 2 hours, single and over 20 treatments evidence_span: {"source_cache": "artifacts/hbot-research/16299259.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "76c0554557a30ac9a32f25b74b27edb5f8f8a57ee0c0660dfe5619b78732c730", "start_char": 0, "end_char": 1502, "text_sha256": "76c0554557a30ac9a32f25b74b27edb5f8f8a57ee0c0660dfe5619b78732c730"} [hbot-p16299259] Stem cell mobilization by hyperbaric oxygen. (2006). https://pubmed.ncbi.nlm.nih.gov/16299259/ DOI: 10.1152/ajpheart.00888.2005
    Complete structured claim and evidence

  2. Diabetic patients showed a more than twofold elevation in circulating stem cells after treatments, and the post-treatment CD34-positive population contained two- to threefold higher levels of hypoxia inducible factors 1, 2 and 3 and of thioredoxin-1.

    Hyperbaric oxygen therapy → Circulating CD34-positive stem and progenitor cells source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/hbot-research/21362081.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a830ae6900d884b73f4e5eac335263db6f9d981a0f95aa45ad3e266c44800e0b", "start_char": 0, "end_char": 1077, "text_sha256": "a830ae6900d884b73f4e5eac335263db6f9d981a0f95aa45ad3e266c44800e0b"}
    experimental_model
    Diabetic patients undergoing hyperbaric oxygen for refractory neuropathic ulcers, with wound margin biopsies
    exposure
    Clinical hyperbaric oxygen therapy courses for refractory lower-extremity ulcers
    limitations
    Human observational measurements within a treatment course, without a randomised comparison. Protein content is measured in the mobilised cells, not in healed tissue.
    nutrient_topic
    Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Hyperbaric oxygen therapy
    organism
    Human
    plain_language
    The cells released carry more of the low-oxygen sensing proteins and more thioredoxin inside them.
    primary_references
    [hbot-p21362081] Vasculogenic stem cell mobilization and wound recruitment in diabetic patients: increased cell number and intracellular regulatory protein content associated with hyperbaric oxygen therapy. (2011). https://pubmed.ncbi.nlm.nih.gov/21362081/ DOI: 10.1111/j.1524-475x.2010.00660.x
    tissue_or_cell_type
    Peripheral blood, platelets and skin wound margins

    Hyperbaric oxygen: the exposure, its reactive species, the signals they carry, and the nutrient-dependent enzymes that handle them (2026-09-19) · lines 582–593

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Diabetic patients undergoing hyperbaric oxygen for refractory neuropathic ulcers, with wound margin biopsies · source_derived_draft · unverified_draft

    ### hbot-diabetic-stem-mobilisation Diabetic patients showed a more than twofold elevation in circulating stem cells after treatments, and the post-treatment CD34-positive population contained two- to threefold higher levels of hypoxia inducible factors 1, 2 and 3 and of thioredoxin-1. Condition category: normal nutrient_topic: Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: The cells released carry more of the low-oxygen sensing proteins and more thioredoxin inside them. organism: Human tissue_or_cell_type: Peripheral blood, platelets and skin wound margins experimental_model: Diabetic patients undergoing hyperbaric oxygen for refractory neuropathic ulcers, with wound margin biopsies limitations: Human observational measurements within a treatment course, without a randomised comparison. Protein content is measured in the mobilised cells, not in healed tissue. exposure: Clinical hyperbaric oxygen therapy courses for refractory lower-extremity ulcers evidence_span: {"source_cache": "artifacts/hbot-research/21362081.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a830ae6900d884b73f4e5eac335263db6f9d981a0f95aa45ad3e266c44800e0b", "start_char": 0, "end_char": 1077, "text_sha256": "a830ae6900d884b73f4e5eac335263db6f9d981a0f95aa45ad3e266c44800e0b"} [hbot-p21362081] Vasculogenic stem cell mobilization and wound recruitment in diabetic patients: increased cell number and intracellular regulatory protein content associated with hyperbaric oxygen therapy. (2011). https://pubmed.ncbi.nlm.nih.gov/21362081/ DOI: 10.1111/j.1524-475x.2010.00660.x
    Complete structured claim and evidence

  3. Stem cell mobilisation did not occur in knockout mice lacking genes for endothelial nitric oxide synthase, and pretreatment of wild-type mice with a nitric oxide synthase inhibitor prevented the elevation in stem cell factor and circulating stem cells.

    Experimental endothelial nitric oxide synthase knockout mouse genotype → Circulating CD34-positive stem and progenitor cells source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/hbot-research/16299259.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "76c0554557a30ac9a32f25b74b27edb5f8f8a57ee0c0660dfe5619b78732c730", "start_char": 0, "end_char": 1502, "text_sha256": "76c0554557a30ac9a32f25b74b27edb5f8f8a57ee0c0660dfe5619b78732c730"}
    experimental_model
    Human volunteers, mice, and endothelial nitric oxide synthase knockout mice
    exposure
    2.0 atmospheres absolute oxygen for 2 hours, single and over 20 treatments
    limitations
    The knockout and inhibitor arms carry the causal claim. Progenitor phenotype is defined by surface markers and colony formation, not by a demonstrated contribution to a healed vessel.
    nutrient_topic
    Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Hyperbaric oxygen therapy
    organism
    Human and mouse
    plain_language
    Remove the enzyme that makes nitric oxide and the cells stay in the marrow.
    primary_references
    [hbot-p16299259] Stem cell mobilization by hyperbaric oxygen. (2006). https://pubmed.ncbi.nlm.nih.gov/16299259/ DOI: 10.1152/ajpheart.00888.2005
    tissue_or_cell_type
    Bone marrow and peripheral blood
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Hyperbaric oxygen: the exposure, its reactive species, the signals they carry, and the nutrient-dependent enzymes that handle them (2026-09-19) · lines 569–580

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human volunteers, mice, and endothelial nitric oxide synthase knockout mice · source_derived_draft · unverified_draft

    ### hbot-nos3-required Stem cell mobilisation did not occur in knockout mice lacking genes for endothelial nitric oxide synthase, and pretreatment of wild-type mice with a nitric oxide synthase inhibitor prevented the elevation in stem cell factor and circulating stem cells. Condition category: machinery_impairment nutrient_topic: Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: Remove the enzyme that makes nitric oxide and the cells stay in the marrow. organism: Human and mouse tissue_or_cell_type: Bone marrow and peripheral blood experimental_model: Human volunteers, mice, and endothelial nitric oxide synthase knockout mice limitations: The knockout and inhibitor arms carry the causal claim. Progenitor phenotype is defined by surface markers and colony formation, not by a demonstrated contribution to a healed vessel. exposure: 2.0 atmospheres absolute oxygen for 2 hours, single and over 20 treatments evidence_span: {"source_cache": "artifacts/hbot-research/16299259.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "76c0554557a30ac9a32f25b74b27edb5f8f8a57ee0c0660dfe5619b78732c730", "start_char": 0, "end_char": 1502, "text_sha256": "76c0554557a30ac9a32f25b74b27edb5f8f8a57ee0c0660dfe5619b78732c730"} [hbot-p16299259] Stem cell mobilization by hyperbaric oxygen. (2006). https://pubmed.ncbi.nlm.nih.gov/16299259/ DOI: 10.1152/ajpheart.00888.2005
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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