Component
Circulating calcifediol retention
Residence of circulating 25-hydroxyvitamin D3 in a measured tracer experiment.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Deletion of mouse vitamin D-binding protein accelerated the loss of injected radiolabeled calcifediol from plasma.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- false
- evidence_location
- Full primary Methods, Vitamin D kinetics; Results, kinetics of 25(OH)D3; abstract.
- experimental_model
- Radiotracer kinetics in Gc-null and wild-type mice
- exposure
- After 4-6 weeks on D3-deficient diet, 0.5 microCi or 100000 cpm tracer in homologous serum was injected intravenously; sampling over 24 h.
- limitations
- Both genotypes experienced dietary depletion; the comparison isolates an additional carrier defect. Tracer plasma residence is not a human dietary-dose trial.
- nutrient
- Vitamin D2 and D3 · Vitamin D2 and D3
- nutrient_topic
- Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin D2 and D3
- organism
- Mus musculus
- plain_language
- The blood carrier helps vitamin D precursor stay in circulation.
- primary_references
- [safadi1999] Osteopathy and resistance to vitamin D toxicity in mice null for vitamin D binding protein. (1999). https://pubmed.ncbi.nlm.nih.gov/9916136/ DOI: 10.1172/jci5244
- tissue_or_cell_type
- plasma and liver
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 272–285
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Radiotracer kinetics in Gc-null and wild-type mice · source_derived_draft · unverified_draft
### vd-act-dbp-null-retention Deletion of mouse vitamin D-binding protein accelerated the loss of injected radiolabeled calcifediol from plasma. Condition category: machinery_impairment nutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. plain_language: The blood carrier helps vitamin D precursor stay in circulation. organism: Mus musculus tissue_or_cell_type: plasma and liver experimental_model: Radiotracer kinetics in Gc-null and wild-type mice limitations: Both genotypes experienced dietary depletion; the comparison isolates an additional carrier defect. Tracer plasma residence is not a human dietary-dose trial. exposure: After 4-6 weeks on D3-deficient diet, 0.5 microCi or 100000 cpm tracer in homologous serum was injected intravenously; sampling over 24 h. cross_nutrient: false evidence_location: Full primary Methods, Vitamin D kinetics; Results, kinetics of 25(OH)D3; abstract. nutrient: Vitamin D2 and D3 [safadi1999] Osteopathy and resistance to vitamin D toxicity in mice null for vitamin D binding protein. (1999). https://pubmed.ncbi.nlm.nih.gov/9916136/ DOI: 10.1172/jci5244
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.