Component
Human alpha7 nicotinic acetylcholine receptor / CHRNA7
Homopentameric ligand-gated cation channel.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Preapplication of ivermectin in the micromolar range strongly enhanced the acetylcholine-evoked current of alpha7 nicotinic acetylcholine receptors, acting as a positive allosteric effector.
Experimental context and source evidence
- duration
- Acute
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- experimental_model
- Chick and human alpha7 nicotinic acetylcholine receptors in Xenopus laevis oocytes and K-28 cells
- exposure
- Micromolar ivermectin preapplication
- limitations
- Micromolar exposure in a heterologous expression system is well above ordinary antiparasitic plasma concentrations, and the authors exclude a nonspecific chloride current rather than establishing an in vivo effect.
- organism
- Chick and human alpha7 nicotinic acetylcholine receptors in Xenopus laevis oocytes and K-28 cells
- plain_language
- Preapplication of ivermectin in the micromolar range strongly enhanced the acetylcholine-evoked current of alpha7 nicotinic acetylcholine receptors, acting as a positive allosteric effector.
- primary_references
- Ivermectin: a positive allosteric effector of the alpha7 neuronal nicotinic acetylcholine receptor. (1998). https://pubmed.ncbi.nlm.nih.gov/9463487/ DOI: 10.1124/mol.53.2.283
- route
- In vitro
- tissue
- Ligand-gated cation channel current
Ivermectin: mechanism of action across parasite, host barrier and mammalian targets (2026-09-22) · lines 79–88
Original AI-assisted curation of sixteen primary studies resolved by PubMed title search and cross-checked against live PubMed metadata. Study-specific citations, concentrations, negative findings and limitations retained. Not publisher full text. · supports · · source_derived_draft · unverified_draft
## ivermectin-alpha7-nicotinic-potentiation Preapplication of ivermectin in the micromolar range strongly enhanced the acetylcholine-evoked current of alpha7 nicotinic acetylcholine receptors, acting as a positive allosteric effector. Model/species: Chick and human alpha7 nicotinic acetylcholine receptors in Xenopus laevis oocytes and K-28 cells Tissue/system: Ligand-gated cation channel current Exposure: Micromolar ivermectin preapplication Route: In vitro Duration: Acute Limits: Micromolar exposure in a heterologous expression system is well above ordinary antiparasitic plasma concentrations, and the authors exclude a nonspecific chloride current rather than establishing an in vivo effect. Primary reference: Ivermectin: a positive allosteric effector of the alpha7 neuronal nicotinic acetylcholine receptor. (1998). https://pubmed.ncbi.nlm.nih.gov/9463487/ DOI: 10.1124/mol.53.2.283 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.