Component
Chicken fatty acid synthase / FASN
Study-scoped entity; inspect species, exposure, model and limitations on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
EGCG inhibited chicken liver FAS through rapid reversible and slower irreversible components; rapid 50% inhibition occurred at 52 micromolar.
Experimental context and source evidence
- experimental_model
- Chicken liver FAS; biochemical kinetics.
- limitations
- Not a human weight-loss trial or a direct measurement of human FASN.
- nutrient_topic
- EGCG collection; comparator and shared-pathway records retain their actual intervention. · Epigallocatechin-3-gallate (EGCG)
- plain_language
- EGCG acted on a lipid-synthesis enzyme in a purified preparation.
- primary_references
- Green tea epigallocatechin gallate: a natural inhibitor of fatty-acid synthase. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11700039/ · DOI 10.1006/bbrc.2001.5923
EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18) · lines 196–202
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Chicken liver FAS; biochemical kinetics. · source_derived_draft · unverified_draft
## egcg-fasn EGCG acted on a lipid-synthesis enzyme in a purified preparation. EGCG inhibited chicken liver FAS through rapid reversible and slower irreversible components; rapid 50% inhibition occurred at 52 micromolar. Model: Chicken liver FAS; biochemical kinetics. Limitations: Not a human weight-loss trial or a direct measurement of human FASN. Evidence access: primary abstract. Green tea epigallocatechin gallate: a natural inhibitor of fatty-acid synthase. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11700039/ · DOI 10.1006/bbrc.2001.5923
Complete structured claim and evidenceNADPH protected against inhibition, and ketoacyl-reductase experiments supported competition near the NADPH-binding function.
Experimental context and source evidence
- experimental_model
- Purified chicken FAS kinetics.
- limitations
- This does not show that niacin supplementation cancels EGCG or improves a clinical outcome.
- nutrient_topic
- EGCG collection; comparator and shared-pathway records retain their actual intervention. · Epigallocatechin-3-gallate (EGCG)
- plain_language
- The enzyme’s reducing cofactor altered EGCG inhibition.
- primary_references
- Green tea epigallocatechin gallate: a natural inhibitor of fatty-acid synthase. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11700039/ · DOI 10.1006/bbrc.2001.5923
EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18) · lines 204–210
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Purified chicken FAS kinetics. · source_derived_draft · unverified_draft
## egcg-fasn-nadph The enzyme’s reducing cofactor altered EGCG inhibition. NADPH protected against inhibition, and ketoacyl-reductase experiments supported competition near the NADPH-binding function. Model: Purified chicken FAS kinetics. Limitations: This does not show that niacin supplementation cancels EGCG or improves a clinical outcome. Evidence access: primary abstract. Green tea epigallocatechin gallate: a natural inhibitor of fatty-acid synthase. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11700039/ · DOI 10.1006/bbrc.2001.5923
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.