{"id":"906981ff-1e47-556c-9192-b0ba3def24b1","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-fasn-nadph","predicate":"protects_against_egcg_inhibition","statement":"NADPH protected against inhibition, and ketoacyl-reductase experiments supported competition near the NADPH-binding function.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"362f0b13-86a3-5c54-b2fb-e4e1f456825a","mechanism_event_label":"The enzyme’s reducing cofactor altered EGCG inhibition.","subject":{"id":"4aba2a5e-8d06-5304-bb01-c0402b225a94","slug":"nadph","display_name":"NADPH","entity_type_key":"small_molecule"},"object":{"id":"fefe83c7-5f2d-50e0-83b9-2e463be0ae68","slug":"chicken-fasn","display_name":"Chicken fatty acid synthase / FASN","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"362f0b13-86a3-5c54-b2fb-e4e1f456825a","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-fasn-nadph-event","event_type":"observed_relationship","label":"The enzyme’s reducing cofactor altered EGCG inhibition.","description":"NADPH protected against inhibition, and ketoacyl-reductase experiments supported competition near the NADPH-binding function.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4aba2a5e-8d06-5304-bb01-c0402b225a94","slug":"nadph","display_name":"NADPH","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"fefe83c7-5f2d-50e0-83b9-2e463be0ae68","slug":"chicken-fasn","display_name":"Chicken fatty acid synthase / FASN","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"22e1b8eb-f35f-5afa-be20-b0534df9f6be","slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Purified chicken FAS kinetics.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This does not show that niacin supplementation cancels EGCG or improves a clinical outcome.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"EGCG collection; comparator and shared-pathway records retain their actual intervention.","comparator":null,"unit":null,"notes":"","entity":{"slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The enzyme’s reducing cofactor altered EGCG inhibition.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Green tea epigallocatechin gallate: a natural inhibitor of fatty-acid synthase. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11700039/ · DOI 10.1006/bbrc.2001.5923","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"55afb77a-c655-542f-a9c9-81c5d154d76e","evidence_kind":"source_excerpt","locator":"Lines 204-210","start_line":204,"end_line":210,"excerpt":"## egcg-fasn-nadph\nThe enzyme’s reducing cofactor altered EGCG inhibition.\nNADPH protected against inhibition, and ketoacyl-reductase experiments supported competition near the NADPH-binding function.\nModel: Purified chicken FAS kinetics.\nLimitations: This does not show that niacin supplementation cancels EGCG or improves a clinical outcome.\nEvidence access: primary abstract.\nGreen tea epigallocatechin gallate: a natural inhibitor of fatty-acid synthase. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11700039/ · DOI 10.1006/bbrc.2001.5923","model_system":"Purified chicken FAS kinetics.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Primary-abstract paraphrase; no full-text methods verification claimed.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1f6d09e8-3aae-5c41-9ea7-15d0d1cab72d","stable_key":"import-ec987f3e-0b3c-55cc-b304-c703a738e35d","title":"EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b101c8d4d96ee03ff97eb1922c7bb0f96943295af473fdc3ef98b0dbd62fe8c7","revision_id":"e19bc5b2-ee3c-5f67-b5c5-9dc3b7d5f850","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}