Component
Human choline dehydrogenase / CHDH
Human choline dehydrogenase / CHDH. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
The pathway model identifies CHDH-mediated oxidation of choline to betaine aldehyde upstream of aldehyde-dehydrogenase-mediated betaine production.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/choline-research/39111307.fulltext.txt", "locator": "Primary full-text span; zero-based, end-exclusive Unicode character offsets", "file_sha256": "086a515ebf324a03baeb82e7fe21771eb7f819da09ef7a22372e06db25d3c571", "start_char": 3335, "end_char": 3656, "text_sha256": "580d72b54dac50ca5d1cfdb4e2ffe3719e957af76ac81d761422471424636d69"}
- experimental_model
- Slc25a48 knockout, rescue, mitochondrial assays and isotope tracing
- exposure
- Biochemical pathway described in the study introduction
- limitations
- Established pathway background in this carrier study, not a newly isolated human CHDH catalytic assay. No cofactor identity or exclusive downstream ALDH isoform is inferred.
- nutrient_topic
- Choline research collection; topical membership is not evidence of a direct dietary effect. · Choline
- organism
- Mammalian pathway background applied to the human-cell arm
- plain_language
- Choline oxidation has an aldehyde intermediate; it is not one undifferentiated jump to betaine.
- primary_references
- [choline-p39111307] SLC25A48 controls mitochondrial choline import and metabolism. (2024). https://pubmed.ncbi.nlm.nih.gov/39111307/ DOI: 10.1016/j.cmet.2024.07.010
- tissue_or_cell_type
- Mitochondrial choline metabolism
Choline: metabolism, signaling and nutrient connections (2026-09-17) · lines 464–475
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Slc25a48 knockout, rescue, mitochondrial assays and isotope tracing · source_derived_draft · unverified_draft
### choline-chdh-aldehyde-step The pathway model identifies CHDH-mediated oxidation of choline to betaine aldehyde upstream of aldehyde-dehydrogenase-mediated betaine production. Condition category: normal nutrient_topic: Choline research collection; topical membership is not evidence of a direct dietary effect. plain_language: Choline oxidation has an aldehyde intermediate; it is not one undifferentiated jump to betaine. organism: Mammalian pathway background applied to the human-cell arm tissue_or_cell_type: Mitochondrial choline metabolism experimental_model: Slc25a48 knockout, rescue, mitochondrial assays and isotope tracing limitations: Established pathway background in this carrier study, not a newly isolated human CHDH catalytic assay. No cofactor identity or exclusive downstream ALDH isoform is inferred. exposure: Biochemical pathway described in the study introduction evidence_span: {"source_cache": "artifacts/choline-research/39111307.fulltext.txt", "locator": "Primary full-text span; zero-based, end-exclusive Unicode character offsets", "file_sha256": "086a515ebf324a03baeb82e7fe21771eb7f819da09ef7a22372e06db25d3c571", "start_char": 3335, "end_char": 3656, "text_sha256": "580d72b54dac50ca5d1cfdb4e2ffe3719e957af76ac81d761422471424636d69"} [choline-p39111307] SLC25A48 controls mitochondrial choline import and metabolism. (2024). https://pubmed.ncbi.nlm.nih.gov/39111307/ DOI: 10.1016/j.cmet.2024.07.010
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.