IND02 C. zeylanicum polyphenol-rich nasal spray: molecular mechanisms & dependencies

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

Human evidence only

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

IND02 nasal spray improved the rhinoconjunctivitis quality-of-life score compared with placebo after seven days.
IND02 C. zeylanicum polyphenol-rich nasal spray → Rhinoconjunctivitis quality-of-life questionnaire score source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/ceylon-research/31780001.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9dec4d6fda0520bf0d9fb8adf77c76254bfc44c05308367b8486a39d8d8611b2", "start_char": 0, "end_char": 1863, "text_sha256": "9dec4d6fda0520bf0d9fb8adf77c76254bfc44c05308367b8486a39d8d8611b2"}
experimental_model
Randomized double-blind placebo-controlled nasal-spray trial
exposure
IND02 100 micrograms/100 microliters in each nostril twice daily for seven days
limitations
Intranasal formulated extract, not eating cinnamon, inhaling powder or using essential oil. Short follow-up and formulation-specific outcomes.
nutrient_topic
Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. · Ceylon cinnamon / Cinnamomum verum bark preparations
organism
Human
plain_language
The tested nasal formulation improved this allergy outcome; the route and preparation are part of the result.
primary_references
[ceylon-p31780001] A randomized, double-blind placebo-controlled study of intranasal standardized cinnamon bark extract for seasonal allergic rhinitis. (2019). https://pubmed.ncbi.nlm.nih.gov/31780001/ DOI: 10.1016/j.ctim.2019.102198
tissue_or_cell_type
Adults 18–75 with seasonal allergic rhinitis
Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17) · lines 1260–1271
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized double-blind placebo-controlled nasal-spray trial · source_derived_draft · unverified_draft
### ceylon-nasal-rqlq IND02 nasal spray improved the rhinoconjunctivitis quality-of-life score compared with placebo after seven days. Condition category: normal nutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. plain_language: The tested nasal formulation improved this allergy outcome; the route and preparation are part of the result. organism: Human tissue_or_cell_type: Adults 18–75 with seasonal allergic rhinitis experimental_model: Randomized double-blind placebo-controlled nasal-spray trial limitations: Intranasal formulated extract, not eating cinnamon, inhaling powder or using essential oil. Short follow-up and formulation-specific outcomes. exposure: IND02 100 micrograms/100 microliters in each nostril twice daily for seven days evidence_span: {"source_cache": "artifacts/ceylon-research/31780001.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9dec4d6fda0520bf0d9fb8adf77c76254bfc44c05308367b8486a39d8d8611b2", "start_char": 0, "end_char": 1863, "text_sha256": "9dec4d6fda0520bf0d9fb8adf77c76254bfc44c05308367b8486a39d8d8611b2"} [ceylon-p31780001] A randomized, double-blind placebo-controlled study of intranasal standardized cinnamon bark extract for seasonal allergic rhinitis. (2019). https://pubmed.ncbi.nlm.nih.gov/31780001/ DOI: 10.1016/j.ctim.2019.102198
Complete structured claim and evidence
IND02 nasal spray improved the total daily rhinitis symptom score compared with placebo after seven days.
IND02 C. zeylanicum polyphenol-rich nasal spray → Seasonal allergic-rhinitis total daily symptom score source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/ceylon-research/31780001.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9dec4d6fda0520bf0d9fb8adf77c76254bfc44c05308367b8486a39d8d8611b2", "start_char": 0, "end_char": 1863, "text_sha256": "9dec4d6fda0520bf0d9fb8adf77c76254bfc44c05308367b8486a39d8d8611b2"}
experimental_model
Randomized double-blind placebo-controlled nasal-spray trial
exposure
IND02 100 micrograms/100 microliters in each nostril twice daily for seven days
limitations
Intranasal formulated extract, not eating cinnamon, inhaling powder or using essential oil. Short follow-up and formulation-specific outcomes.
nutrient_topic
Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. · Ceylon cinnamon / Cinnamomum verum bark preparations
organism
Human
plain_language
The tested nasal formulation improved this allergy outcome; the route and preparation are part of the result.
primary_references
[ceylon-p31780001] A randomized, double-blind placebo-controlled study of intranasal standardized cinnamon bark extract for seasonal allergic rhinitis. (2019). https://pubmed.ncbi.nlm.nih.gov/31780001/ DOI: 10.1016/j.ctim.2019.102198
tissue_or_cell_type
Adults 18–75 with seasonal allergic rhinitis
Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17) · lines 1273–1284
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized double-blind placebo-controlled nasal-spray trial · source_derived_draft · unverified_draft
### ceylon-nasal-symptoms IND02 nasal spray improved the total daily rhinitis symptom score compared with placebo after seven days. Condition category: normal nutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. plain_language: The tested nasal formulation improved this allergy outcome; the route and preparation are part of the result. organism: Human tissue_or_cell_type: Adults 18–75 with seasonal allergic rhinitis experimental_model: Randomized double-blind placebo-controlled nasal-spray trial limitations: Intranasal formulated extract, not eating cinnamon, inhaling powder or using essential oil. Short follow-up and formulation-specific outcomes. exposure: IND02 100 micrograms/100 microliters in each nostril twice daily for seven days evidence_span: {"source_cache": "artifacts/ceylon-research/31780001.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9dec4d6fda0520bf0d9fb8adf77c76254bfc44c05308367b8486a39d8d8611b2", "start_char": 0, "end_char": 1863, "text_sha256": "9dec4d6fda0520bf0d9fb8adf77c76254bfc44c05308367b8486a39d8d8611b2"} [ceylon-p31780001] A randomized, double-blind placebo-controlled study of intranasal standardized cinnamon bark extract for seasonal allergic rhinitis. (2019). https://pubmed.ncbi.nlm.nih.gov/31780001/ DOI: 10.1016/j.ctim.2019.102198
Complete structured claim and evidence

The events it takes part in

A mechanism often involves more than two components. These are the full events, with every participant and its role.

Situations it appears in

Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

Open hypotheses

Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.

This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

IND02 C. zeylanicum polyphenol-rich nasal spray