{"id":"fefbea32-2903-50dc-a8ed-184669c360ef","stable_key":"3d41d18a-e13a-59a0-a081-55bfcdd43e55:ceylon-nasal-symptoms","predicate":"improves","statement":"IND02 nasal spray improved the total daily rhinitis symptom score compared with placebo after seven days.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"ca73ea28-167b-5b10-8339-fbbf51d1bb33","mechanism_event_label":"The tested nasal formulation improved this allergy outcome; the route and preparation are part of the result.","subject":{"id":"db758cff-b71d-5927-8c69-46d8a2524f8d","slug":"ceylon-ind02-nasal","display_name":"IND02 C. zeylanicum polyphenol-rich nasal spray","entity_type_key":"chemical_species"},"object":{"id":"9dd3fa59-08c6-5690-bc99-250aa7b9e368","slug":"rhinitis-daily-symptom-score","display_name":"Seasonal allergic-rhinitis total daily symptom score","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ca73ea28-167b-5b10-8339-fbbf51d1bb33","stable_key":"3d41d18a-e13a-59a0-a081-55bfcdd43e55:ceylon-nasal-symptoms-event","event_type":"observed_intervention","label":"The tested nasal formulation improved this allergy outcome; the route and preparation are part of the result.","description":"IND02 nasal spray improved the total daily rhinitis symptom score compared with placebo after seven days.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"db758cff-b71d-5927-8c69-46d8a2524f8d","slug":"ceylon-ind02-nasal","display_name":"IND02 C. zeylanicum polyphenol-rich nasal spray","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9dd3fa59-08c6-5690-bc99-250aa7b9e368","slug":"rhinitis-daily-symptom-score","display_name":"Seasonal allergic-rhinitis total daily symptom score","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/ceylon-research/31780001.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"9dec4d6fda0520bf0d9fb8adf77c76254bfc44c05308367b8486a39d8d8611b2\", \"start_char\": 0, \"end_char\": 1863, \"text_sha256\": \"9dec4d6fda0520bf0d9fb8adf77c76254bfc44c05308367b8486a39d8d8611b2\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized double-blind placebo-controlled nasal-spray trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"IND02 100 micrograms/100 microliters in each nostril twice daily for seven days","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Intranasal formulated extract, not eating cinnamon, inhaling powder or using essential oil. Short follow-up and formulation-specific outcomes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ceylon","display_name":"Ceylon cinnamon / Cinnamomum verum bark preparations","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The tested nasal formulation improved this allergy outcome; the route and preparation are part of the result.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ceylon-p31780001] A randomized, double-blind placebo-controlled study of intranasal standardized cinnamon bark extract for seasonal allergic rhinitis. (2019). https://pubmed.ncbi.nlm.nih.gov/31780001/ DOI: 10.1016/j.ctim.2019.102198","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Adults 18–75 with seasonal allergic rhinitis","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"184389b7-30b6-5156-ac81-f208f82dab96","evidence_kind":"source_excerpt","locator":"Lines 1273-1284","start_line":1273,"end_line":1284,"excerpt":"### ceylon-nasal-symptoms\nIND02 nasal spray improved the total daily rhinitis symptom score compared with placebo after seven days.\nCondition category: normal\nnutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The tested nasal formulation improved this allergy outcome; the route and preparation are part of the result.\norganism: Human\ntissue_or_cell_type: Adults 18–75 with seasonal allergic rhinitis\nexperimental_model: Randomized double-blind placebo-controlled nasal-spray trial\nlimitations: Intranasal formulated extract, not eating cinnamon, inhaling powder or using essential oil. Short follow-up and formulation-specific outcomes.\nexposure: IND02 100 micrograms/100 microliters in each nostril twice daily for seven days\nevidence_span: {\"source_cache\": \"artifacts/ceylon-research/31780001.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"9dec4d6fda0520bf0d9fb8adf77c76254bfc44c05308367b8486a39d8d8611b2\", \"start_char\": 0, \"end_char\": 1863, \"text_sha256\": \"9dec4d6fda0520bf0d9fb8adf77c76254bfc44c05308367b8486a39d8d8611b2\"}\n[ceylon-p31780001] A randomized, double-blind placebo-controlled study of intranasal standardized cinnamon bark extract for seasonal allergic rhinitis. 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