C. zeylanicum bark oil in the 2018 Candida study: molecular mechanisms & dependencies

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

Human evidence only

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

The bark oil compromised Candida membrane integrity and allowed cellular-component leakage.
C. zeylanicum bark oil in the 2018 Candida study → Candida albicans membrane leakage source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/ceylon-research/29456868.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a42223fd2d170b3cba7a0d3ab2670bb33bde4e05c1be831f6ebac45c66ecbce2", "start_char": 0, "end_char": 1751, "text_sha256": "a42223fd2d170b3cba7a0d3ab2670bb33bde4e05c1be831f6ebac45c66ecbce2"}
experimental_model
Cultured yeast imaging, viability and cell-wall mutant assays
exposure
Oil including subinhibitory 62.5 micrograms/mL; cinnamaldehyde MIC 112 micrograms/mL
limitations
In-vitro antifungal activity is not clinical eradication; fungal spindle effects do not establish equivalent mammalian tubulin inhibition.
nutrient_topic
Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. · Ceylon cinnamon / Cinnamomum verum bark preparations
organism
Candida albicans RSY150 and clinical isolates
plain_language
The cultured fungal cells lost membrane containment.
primary_references
[ceylon-p29456868] Cinnamomum zeylanicum bark essential oil induces cell wall remodelling and spindle defects in Candida albicans. (2018). https://pubmed.ncbi.nlm.nih.gov/29456868/ DOI: 10.1186/s40694-018-0046-5
tissue_or_cell_type
Fungal cell wall, membrane and mitotic spindle
Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17) · lines 974–985
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Cultured yeast imaging, viability and cell-wall mutant assays · source_derived_draft · unverified_draft
### ceylon-candida-leak The bark oil compromised Candida membrane integrity and allowed cellular-component leakage. Condition category: normal nutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. plain_language: The cultured fungal cells lost membrane containment. organism: Candida albicans RSY150 and clinical isolates tissue_or_cell_type: Fungal cell wall, membrane and mitotic spindle experimental_model: Cultured yeast imaging, viability and cell-wall mutant assays limitations: In-vitro antifungal activity is not clinical eradication; fungal spindle effects do not establish equivalent mammalian tubulin inhibition. exposure: Oil including subinhibitory 62.5 micrograms/mL; cinnamaldehyde MIC 112 micrograms/mL evidence_span: {"source_cache": "artifacts/ceylon-research/29456868.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a42223fd2d170b3cba7a0d3ab2670bb33bde4e05c1be831f6ebac45c66ecbce2", "start_char": 0, "end_char": 1751, "text_sha256": "a42223fd2d170b3cba7a0d3ab2670bb33bde4e05c1be831f6ebac45c66ecbce2"} [ceylon-p29456868] Cinnamomum zeylanicum bark essential oil induces cell wall remodelling and spindle defects in Candida albicans. (2018). https://pubmed.ncbi.nlm.nih.gov/29456868/ DOI: 10.1186/s40694-018-0046-5
Complete structured claim and evidence
The bark oil reduced Candida cell-wall integrity and altered cell-surface ultrastructure.
C. zeylanicum bark oil in the 2018 Candida study → Candida albicans cell-wall integrity source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/ceylon-research/29456868.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a42223fd2d170b3cba7a0d3ab2670bb33bde4e05c1be831f6ebac45c66ecbce2", "start_char": 0, "end_char": 1751, "text_sha256": "a42223fd2d170b3cba7a0d3ab2670bb33bde4e05c1be831f6ebac45c66ecbce2"}
experimental_model
Cultured yeast imaging, viability and cell-wall mutant assays
exposure
Oil including subinhibitory 62.5 micrograms/mL; cinnamaldehyde MIC 112 micrograms/mL
limitations
In-vitro antifungal activity is not clinical eradication; fungal spindle effects do not establish equivalent mammalian tubulin inhibition.
nutrient_topic
Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. · Ceylon cinnamon / Cinnamomum verum bark preparations
organism
Candida albicans RSY150 and clinical isolates
plain_language
The fungal surface was damaged in culture.
primary_references
[ceylon-p29456868] Cinnamomum zeylanicum bark essential oil induces cell wall remodelling and spindle defects in Candida albicans. (2018). https://pubmed.ncbi.nlm.nih.gov/29456868/ DOI: 10.1186/s40694-018-0046-5
tissue_or_cell_type
Fungal cell wall, membrane and mitotic spindle
Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17) · lines 961–972
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Cultured yeast imaging, viability and cell-wall mutant assays · source_derived_draft · unverified_draft
### ceylon-candida-wall The bark oil reduced Candida cell-wall integrity and altered cell-surface ultrastructure. Condition category: normal nutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. plain_language: The fungal surface was damaged in culture. organism: Candida albicans RSY150 and clinical isolates tissue_or_cell_type: Fungal cell wall, membrane and mitotic spindle experimental_model: Cultured yeast imaging, viability and cell-wall mutant assays limitations: In-vitro antifungal activity is not clinical eradication; fungal spindle effects do not establish equivalent mammalian tubulin inhibition. exposure: Oil including subinhibitory 62.5 micrograms/mL; cinnamaldehyde MIC 112 micrograms/mL evidence_span: {"source_cache": "artifacts/ceylon-research/29456868.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a42223fd2d170b3cba7a0d3ab2670bb33bde4e05c1be831f6ebac45c66ecbce2", "start_char": 0, "end_char": 1751, "text_sha256": "a42223fd2d170b3cba7a0d3ab2670bb33bde4e05c1be831f6ebac45c66ecbce2"} [ceylon-p29456868] Cinnamomum zeylanicum bark essential oil induces cell wall remodelling and spindle defects in Candida albicans. (2018). https://pubmed.ncbi.nlm.nih.gov/29456868/ DOI: 10.1186/s40694-018-0046-5
Complete structured claim and evidence

The events it takes part in

A mechanism often involves more than two components. These are the full events, with every participant and its role.

Situations it appears in

Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

Open hypotheses

Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.

This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

C. zeylanicum bark oil in the 2018 Candida study