{"id":"07bfd765-5255-513b-bdf8-0922a534ab0e","stable_key":"3d41d18a-e13a-59a0-a081-55bfcdd43e55:ceylon-candida-leak","predicate":"increases","statement":"The bark oil compromised Candida membrane integrity and allowed cellular-component leakage.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"bd280330-a5f9-51cf-bcf2-80bb6756ecd7","mechanism_event_label":"The cultured fungal cells lost membrane containment.","subject":{"id":"bac0f1ca-7eda-5b9d-803d-f9a8c89cc518","slug":"ceylon-bark-oil-candida","display_name":"C. zeylanicum bark oil in the 2018 Candida study","entity_type_key":"chemical_species"},"object":{"id":"8feb2e3b-5dd7-5fd4-a203-fef1eb843e88","slug":"candida-membrane-leakage","display_name":"Candida albicans membrane leakage","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"bd280330-a5f9-51cf-bcf2-80bb6756ecd7","stable_key":"3d41d18a-e13a-59a0-a081-55bfcdd43e55:ceylon-candida-leak-event","event_type":"biochemical_relationship","label":"The cultured fungal cells lost membrane containment.","description":"The bark oil compromised Candida membrane integrity and allowed cellular-component leakage.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"bac0f1ca-7eda-5b9d-803d-f9a8c89cc518","slug":"ceylon-bark-oil-candida","display_name":"C. zeylanicum bark oil in the 2018 Candida study","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8feb2e3b-5dd7-5fd4-a203-fef1eb843e88","slug":"candida-membrane-leakage","display_name":"Candida albicans membrane leakage","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/ceylon-research/29456868.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"a42223fd2d170b3cba7a0d3ab2670bb33bde4e05c1be831f6ebac45c66ecbce2\", \"start_char\": 0, \"end_char\": 1751, \"text_sha256\": \"a42223fd2d170b3cba7a0d3ab2670bb33bde4e05c1be831f6ebac45c66ecbce2\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cultured yeast imaging, viability and cell-wall mutant assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Oil including subinhibitory 62.5 micrograms/mL; cinnamaldehyde MIC 112 micrograms/mL","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"In-vitro antifungal activity is not clinical eradication; fungal spindle effects do not establish equivalent mammalian tubulin inhibition.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ceylon","display_name":"Ceylon cinnamon / Cinnamomum verum bark preparations","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Candida albicans RSY150 and clinical isolates","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The cultured fungal cells lost membrane containment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ceylon-p29456868] Cinnamomum zeylanicum bark essential oil induces cell wall remodelling and spindle defects in Candida albicans. 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