Component
Regression of cervical intraepithelial lesions
Regression of cervical intraepithelial lesions. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The pilot study found no statistically significant difference between DIM and placebo on its reported outcomes.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/dim-research/19939441.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ba95e25bccf862a414ecb9d5b54d2c95f19d76f5c2bc5cb5176ec31e635c5777", "start_char": 0, "end_char": 2504, "text_sha256": "ba95e25bccf862a414ecb9d5b54d2c95f19d76f5c2bc5cb5176ec31e635c5777"}
- experimental_model
- Randomized placebo-controlled pilot trial
- exposure
- Oral DIM approximately 2 mg/kg/day for 12 weeks
- limitations
- Incomplete follow-up biopsies and improvement in both arms; no statistically significant group difference.
- nutrient_topic
- Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect. · 3,3'-Diindolylmethane / DIM
- organism
- 64 women enrolled; 60 available for analysis
- plain_language
- Improvement within a treated group is not proof that the treatment caused it.
- primary_references
- [dim-p19939441] Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia. (2010). https://pubmed.ncbi.nlm.nih.gov/19939441/ DOI: 10.1016/j.ygyno.2009.10.060
- tissue_or_cell_type
- Biopsy-confirmed CIN2/3
Diindolylmethane (DIM): formation, receptor signaling, metabolism and drug interactions (2026-09-17) · lines 1195–1206
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized placebo-controlled pilot trial · source_derived_draft · unverified_draft
### dim-cervical-pilot-null The pilot study found no statistically significant difference between DIM and placebo on its reported outcomes. Condition category: normal nutrient_topic: Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect. plain_language: Improvement within a treated group is not proof that the treatment caused it. organism: 64 women enrolled; 60 available for analysis tissue_or_cell_type: Biopsy-confirmed CIN2/3 experimental_model: Randomized placebo-controlled pilot trial limitations: Incomplete follow-up biopsies and improvement in both arms; no statistically significant group difference. exposure: Oral DIM approximately 2 mg/kg/day for 12 weeks evidence_span: {"source_cache": "artifacts/dim-research/19939441.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ba95e25bccf862a414ecb9d5b54d2c95f19d76f5c2bc5cb5176ec31e635c5777", "start_char": 0, "end_char": 2504, "text_sha256": "ba95e25bccf862a414ecb9d5b54d2c95f19d76f5c2bc5cb5176ec31e635c5777"} [dim-p19939441] Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia. (2010). https://pubmed.ncbi.nlm.nih.gov/19939441/ DOI: 10.1016/j.ygyno.2009.10.060
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.