{"id":"be00829e-ee6a-5f3b-821c-911894216fa2","stable_key":"182336c6-ed36-5ec6-8a09-25c31096262e:dim-cervical-pilot-null","predicate":"did_not_outperform_placebo_for","statement":"The pilot study found no statistically significant difference between DIM and placebo on its reported outcomes.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"189c4770-c036-5b55-8488-d82c6cf52ea6","mechanism_event_label":"Improvement within a treated group is not proof that the treatment caused it.","subject":{"id":"6009bdd4-f1b5-5867-b5c3-cdf7c9645cd0","slug":"dim","display_name":"3,3'-Diindolylmethane / DIM","entity_type_key":"small_molecule"},"object":{"id":"3793296a-7380-5b41-9a09-1aad2455a187","slug":"cervical-lesion-regression","display_name":"Regression of cervical intraepithelial lesions","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"189c4770-c036-5b55-8488-d82c6cf52ea6","stable_key":"182336c6-ed36-5ec6-8a09-25c31096262e:dim-cervical-pilot-null-event","event_type":"observed_intervention","label":"Improvement within a treated group is not proof that the treatment caused it.","description":"The pilot study found no statistically significant difference between DIM and placebo on its reported outcomes.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6009bdd4-f1b5-5867-b5c3-cdf7c9645cd0","slug":"dim","display_name":"3,3'-Diindolylmethane / DIM","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3793296a-7380-5b41-9a09-1aad2455a187","slug":"cervical-lesion-regression","display_name":"Regression of cervical intraepithelial lesions","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/dim-research/19939441.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"ba95e25bccf862a414ecb9d5b54d2c95f19d76f5c2bc5cb5176ec31e635c5777\", \"start_char\": 0, \"end_char\": 2504, \"text_sha256\": \"ba95e25bccf862a414ecb9d5b54d2c95f19d76f5c2bc5cb5176ec31e635c5777\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized placebo-controlled pilot trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Oral DIM approximately 2 mg/kg/day for 12 weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Incomplete follow-up biopsies and improvement in both arms; no statistically significant group difference.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"dim","display_name":"3,3'-Diindolylmethane / DIM","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"64 women enrolled; 60 available for analysis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Improvement within a treated group is not proof that the treatment caused it.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[dim-p19939441] Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia. (2010). https://pubmed.ncbi.nlm.nih.gov/19939441/ DOI: 10.1016/j.ygyno.2009.10.060","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Biopsy-confirmed CIN2/3","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ff1effec-ddae-5691-83f1-c99e20e18c58","evidence_kind":"source_excerpt","locator":"Lines 1195-1206","start_line":1195,"end_line":1206,"excerpt":"### dim-cervical-pilot-null\nThe pilot study found no statistically significant difference between DIM and placebo on its reported outcomes.\nCondition category: normal\nnutrient_topic: Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Improvement within a treated group is not proof that the treatment caused it.\norganism: 64 women enrolled; 60 available for analysis\ntissue_or_cell_type: Biopsy-confirmed CIN2/3\nexperimental_model: Randomized placebo-controlled pilot trial\nlimitations: Incomplete follow-up biopsies and improvement in both arms; no statistically significant group difference.\nexposure: Oral DIM approximately 2 mg/kg/day for 12 weeks\nevidence_span: {\"source_cache\": \"artifacts/dim-research/19939441.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"ba95e25bccf862a414ecb9d5b54d2c95f19d76f5c2bc5cb5176ec31e635c5777\", \"start_char\": 0, \"end_char\": 2504, \"text_sha256\": \"ba95e25bccf862a414ecb9d5b54d2c95f19d76f5c2bc5cb5176ec31e635c5777\"}\n[dim-p19939441] Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia. 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