Component
Cellular zinc secretion
Cellular zinc secretion
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Coexpressing human ZnT2 H54R with wild-type ZnT2 did not abolish the increased zinc secretion produced by wild-type ZnT2 overexpression alone.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- false
- experimental_model
- Wild-type/mutant coexpression in HEK293 cells
- exposure
- H54R plus wild type compared with wild type alone.
- limitations
- Negative result in an overexpression assay; it does not establish complete compensation in lactating women or the penetrance of the variant.
- nutrient_topic
- Zinc research collection; topical membership is not evidence of a direct dietary effect. · Zinc
- organism
- Homo sapiens
- plain_language
- In this assay, the H54R variant did not block the working ZnT2 protein.
- primary_references
- [zinc-trans-17065149] Identification of a mutation in SLC30A2 (ZnT-2) in women with low milk zinc concentration that results in transient neonatal zinc deficiency. (2006). https://pubmed.ncbi.nlm.nih.gov/17065149/ DOI: 10.1074/jbc.m605821200
- tissue_or_cell_type
- HEK293 cells
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17) · lines 323–334
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Wild-type/mutant coexpression in HEK293 cells · source_derived_draft · unverified_draft
### zinc-trans-znt2-h54r-coexpression Coexpressing human ZnT2 H54R with wild-type ZnT2 did not abolish the increased zinc secretion produced by wild-type ZnT2 overexpression alone. Condition category: machinery_impairment nutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect. plain_language: In this assay, the H54R variant did not block the working ZnT2 protein. organism: Homo sapiens tissue_or_cell_type: HEK293 cells experimental_model: Wild-type/mutant coexpression in HEK293 cells limitations: Negative result in an overexpression assay; it does not establish complete compensation in lactating women or the penetrance of the variant. exposure: H54R plus wild type compared with wild type alone. cross_nutrient: false [zinc-trans-17065149] Identification of a mutation in SLC30A2 (ZnT-2) in women with low milk zinc concentration that results in transient neonatal zinc deficiency. (2006). https://pubmed.ncbi.nlm.nih.gov/17065149/ DOI: 10.1074/jbc.m605821200
Complete structured claim and evidenceHuman ZnT2 H54R expressed in HEK293 cells accumulated in perinuclear aggresomal structures and showed reduced zinc secretion.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- false
- experimental_model
- H54R expression and localization assays in HEK293 cells
- exposure
- H54R compared with wild-type ZnT2.
- limitations
- Cultured kidney-derived cells do not reproduce all lactating mammary processes; a specific variant cannot represent all maternal low-zinc milk.
- nutrient_topic
- Zinc research collection; topical membership is not evidence of a direct dietary effect. · Zinc
- organism
- Homo sapiens
- plain_language
- A milk-zinc-associated ZnT2 variant was misplaced inside cells and exported less zinc.
- primary_references
- [zinc-trans-17065149] Identification of a mutation in SLC30A2 (ZnT-2) in women with low milk zinc concentration that results in transient neonatal zinc deficiency. (2006). https://pubmed.ncbi.nlm.nih.gov/17065149/ DOI: 10.1074/jbc.m605821200
- tissue_or_cell_type
- HEK293 cells; variant identified in mothers with low milk zinc
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17) · lines 310–321
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · H54R expression and localization assays in HEK293 cells · source_derived_draft · unverified_draft
### zinc-trans-znt2-h54r-export Human ZnT2 H54R expressed in HEK293 cells accumulated in perinuclear aggresomal structures and showed reduced zinc secretion. Condition category: machinery_impairment nutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect. plain_language: A milk-zinc-associated ZnT2 variant was misplaced inside cells and exported less zinc. organism: Homo sapiens tissue_or_cell_type: HEK293 cells; variant identified in mothers with low milk zinc experimental_model: H54R expression and localization assays in HEK293 cells limitations: Cultured kidney-derived cells do not reproduce all lactating mammary processes; a specific variant cannot represent all maternal low-zinc milk. exposure: H54R compared with wild-type ZnT2. cross_nutrient: false [zinc-trans-17065149] Identification of a mutation in SLC30A2 (ZnT-2) in women with low milk zinc concentration that results in transient neonatal zinc deficiency. (2006). https://pubmed.ncbi.nlm.nih.gov/17065149/ DOI: 10.1074/jbc.m605821200
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.