Component

Cellular pyridoxine uptake

Uptake of the pyridoxine form of B6; not total vitamin B6 metabolism.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Human SLC19A3 expression increased pyridoxine uptake at pH 5.5; transport favored acidic over neutral/basic conditions.

    Human thiamine transporter 2 / SLC19A3 → Cellular pyridoxine uptake source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    A pH-dependent shared transport route links B1 and the pyridoxine form of B6.
    evidence-scope
    Cultured epithelial cells
    evidence_locator
    Figures 1-3, 6 and 9
    evidence_spans
    [{"source_document": "artifacts/thiamine_transport_sources/yamashiro-2020-pyridoxine-source-record.json", "source_field": "resultList.result[0].abstractText", "start_char": 0, "end_char": 1718}]
    experimental_model
    Human transporter constructs in MDCKII/HEK293 cells; radiotracer uptake at pH 5.5.
    extracellular-pH
    5.5
    limitations
    No systemic B6 transport fraction or supplementation benefit established.
    nutrient_topic
    Thiamine research collection; topical membership is not evidence of a direct dietary effect. · Thiamine (vitamin B1)
    organism
    Human proteins; canine and human cell hosts
    plain_language
    The B1 carrier can also carry one B6 form under acidic conditions.
    primary_references
    [yamashiro-2020-pyridoxine] pH-dependent pyridoxine transport by SLC19A2 and SLC19A3: Implications for absorption in acidic microclimates (2020). https://pmc.ncbi.nlm.nih.gov/articles/PMC7863892/ DOI: 10.1074/jbc.RA120.013610
    tissue_or_cell_type
    Cultured epithelial cells

    Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 631–645

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human transporter constructs in MDCKII/HEK293 cells; radiotracer uptake at pH 5.5. · source_derived_draft · unverified_draft

    ### b1-slc19a3-pyridoxine-transport Human SLC19A3 expression increased pyridoxine uptake at pH 5.5; transport favored acidic over neutral/basic conditions. Condition category: normal nutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect. plain_language: The B1 carrier can also carry one B6 form under acidic conditions. organism: Human proteins; canine and human cell hosts tissue_or_cell_type: Cultured epithelial cells experimental_model: Human transporter constructs in MDCKII/HEK293 cells; radiotracer uptake at pH 5.5. limitations: No systemic B6 transport fraction or supplementation benefit established. cross_nutrient: A pH-dependent shared transport route links B1 and the pyridoxine form of B6. evidence_spans: [{"source_document": "artifacts/thiamine_transport_sources/yamashiro-2020-pyridoxine-source-record.json", "source_field": "resultList.result[0].abstractText", "start_char": 0, "end_char": 1718}] evidence_locator: Figures 1-3, 6 and 9 extracellular-pH: 5.5 evidence-scope: Cultured epithelial cells [yamashiro-2020-pyridoxine] pH-dependent pyridoxine transport by SLC19A2 and SLC19A3: Implications for absorption in acidic microclimates (2020). https://pmc.ncbi.nlm.nih.gov/articles/PMC7863892/ DOI: 10.1074/jbc.RA120.013610
    Complete structured claim and evidence

  2. Thiamine inhibited SLC19A2- and SLC19A3-mediated pyridoxine uptake in acidic-pH transfectant assays.

    Thiamine (vitamin B1) → Cellular pyridoxine uptake source_derived_draftungraded
    Experimental context and source evidence
    cross_nutrient
    Direct B1-to-pyridoxine transport inhibition is demonstrated in vitro, with pH and exposure limitations.
    evidence-scope
    Cultured epithelial cells
    evidence_locator
    Figures 1-3, 6 and 9
    evidence_spans
    [{"source_document": "artifacts/thiamine_transport_sources/yamashiro-2020-pyridoxine-source-record.json", "source_field": "resultList.result[0].abstractText", "start_char": 0, "end_char": 1718}]
    experimental_model
    Human transporter constructs in MDCKII/HEK293 cells; radiotracer uptake at pH 5.5.
    extracellular-pH
    5.5
    limitations
    Assay inhibition does not show clinical B6 deficiency from dietary thiamine.
    nutrient_topic
    Thiamine research collection; topical membership is not evidence of a direct dietary effect. · Thiamine (vitamin B1)
    organism
    Human proteins; canine and human cell hosts
    plain_language
    B1 reduced uptake of a B6 form in these transporter experiments.
    primary_references
    [yamashiro-2020-pyridoxine] pH-dependent pyridoxine transport by SLC19A2 and SLC19A3: Implications for absorption in acidic microclimates (2020). https://pmc.ncbi.nlm.nih.gov/articles/PMC7863892/ DOI: 10.1074/jbc.RA120.013610
    tissue_or_cell_type
    Cultured epithelial cells

    Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 647–661

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human transporter constructs in MDCKII/HEK293 cells; radiotracer uptake at pH 5.5. · source_derived_draft · unverified_draft

    ### b1-thiamine-inhibits-pyridoxine-uptake Thiamine inhibited SLC19A2- and SLC19A3-mediated pyridoxine uptake in acidic-pH transfectant assays. Condition category: normal nutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect. plain_language: B1 reduced uptake of a B6 form in these transporter experiments. organism: Human proteins; canine and human cell hosts tissue_or_cell_type: Cultured epithelial cells experimental_model: Human transporter constructs in MDCKII/HEK293 cells; radiotracer uptake at pH 5.5. limitations: Assay inhibition does not show clinical B6 deficiency from dietary thiamine. cross_nutrient: Direct B1-to-pyridoxine transport inhibition is demonstrated in vitro, with pH and exposure limitations. evidence_spans: [{"source_document": "artifacts/thiamine_transport_sources/yamashiro-2020-pyridoxine-source-record.json", "source_field": "resultList.result[0].abstractText", "start_char": 0, "end_char": 1718}] evidence_locator: Figures 1-3, 6 and 9 extracellular-pH: 5.5 evidence-scope: Cultured epithelial cells [yamashiro-2020-pyridoxine] pH-dependent pyridoxine transport by SLC19A2 and SLC19A3: Implications for absorption in acidic microclimates (2020). https://pmc.ncbi.nlm.nih.gov/articles/PMC7863892/ DOI: 10.1074/jbc.RA120.013610
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards