Component
Cellular iron export
Cellular iron export. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Hepcidin-induced ferroportin removal reduced cellular iron export.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/iron-research/15514116.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "00a292f6693116798182b0f9418f2eb8466aa029f32905019416422002158c4a", "start_char": 0, "end_char": 758, "text_sha256": "00a292f6693116798182b0f9418f2eb8466aa029f32905019416422002158c4a"}
- experimental_model
- Hepcidin binding and cellular export experiments
- exposure
- Hepcidin exposure
- limitations
- Post-translational export regulation; no dose-response to dietary iron is inferred from the cell experiment.
- nutrient_topic
- Iron research collection; topical membership is not evidence of a direct dietary effect. · Iron
- organism
- Tissue-culture ferroportin systems
- plain_language
- Iron can be held inside cells instead of reaching the circulation.
- primary_references
- [iron-p15514116] Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. (2004). https://pubmed.ncbi.nlm.nih.gov/15514116/ DOI: 10.1126/science.1104742
- tissue_or_cell_type
- Plasma membrane
Iron: absorption, trafficking, iron-dependent enzymes and nutrient interactions (2026-09-17) · lines 732–743
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Hepcidin binding and cellular export experiments · source_derived_draft · unverified_draft
### iron-hepcidin-export Hepcidin-induced ferroportin removal reduced cellular iron export. Condition category: normal nutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect. plain_language: Iron can be held inside cells instead of reaching the circulation. organism: Tissue-culture ferroportin systems tissue_or_cell_type: Plasma membrane experimental_model: Hepcidin binding and cellular export experiments limitations: Post-translational export regulation; no dose-response to dietary iron is inferred from the cell experiment. exposure: Hepcidin exposure evidence_span: {"source_cache": "artifacts/iron-research/15514116.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "00a292f6693116798182b0f9418f2eb8466aa029f32905019416422002158c4a", "start_char": 0, "end_char": 758, "text_sha256": "00a292f6693116798182b0f9418f2eb8466aa029f32905019416422002158c4a"} [iron-p15514116] Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. (2004). https://pubmed.ncbi.nlm.nih.gov/15514116/ DOI: 10.1126/science.1104742
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.