{"id":"0d049d19-495e-57b8-8d41-089661dd87ef","stable_key":"e13b03e1-a614-543a-ac1b-97df18cfe30d:iron-hepcidin-export","predicate":"reduces","statement":"Hepcidin-induced ferroportin removal reduced cellular iron export.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"71d980cf-e58c-56f2-97e3-e7ebc5aa599f","mechanism_event_label":"Iron can be held inside cells instead of reaching the circulation.","subject":{"id":"6d4be6b8-eba9-5d6b-93f9-4642b87f7b6f","slug":"hamp","display_name":"Hepcidin","entity_type_key":"protein"},"object":{"id":"9908f520-9246-57c4-acce-627e53b9c20b","slug":"cellular-iron-efflux","display_name":"Cellular iron export","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"71d980cf-e58c-56f2-97e3-e7ebc5aa599f","stable_key":"e13b03e1-a614-543a-ac1b-97df18cfe30d:iron-hepcidin-export-event","event_type":"biochemical_relationship","label":"Iron can be held inside cells instead of reaching the circulation.","description":"Hepcidin-induced ferroportin removal reduced cellular iron export.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2210be14-d81c-5a26-a3fb-5b566f47f1fd","slug":"slc40a1","display_name":"Ferroportin / SLC40A1","entity_type_key":"protein"},"role":"exporter","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"role":"retained_element","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"6d4be6b8-eba9-5d6b-93f9-4642b87f7b6f","slug":"hamp","display_name":"Hepcidin","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"9908f520-9246-57c4-acce-627e53b9c20b","slug":"cellular-iron-efflux","display_name":"Cellular iron export","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/iron-research/15514116.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"00a292f6693116798182b0f9418f2eb8466aa029f32905019416422002158c4a\", \"start_char\": 0, \"end_char\": 758, \"text_sha256\": \"00a292f6693116798182b0f9418f2eb8466aa029f32905019416422002158c4a\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Hepcidin binding and cellular export experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Hepcidin exposure","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Post-translational export regulation; no dose-response to dietary iron is inferred from the cell experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Iron research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Tissue-culture ferroportin systems","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Iron can be held inside cells instead of reaching the circulation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[iron-p15514116] Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. (2004). https://pubmed.ncbi.nlm.nih.gov/15514116/ DOI: 10.1126/science.1104742","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma membrane","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"bc320d70-06a4-5949-ae00-231e3a5b0736","evidence_kind":"source_excerpt","locator":"Lines 732-743","start_line":732,"end_line":743,"excerpt":"### iron-hepcidin-export\nHepcidin-induced ferroportin removal reduced cellular iron export.\nCondition category: normal\nnutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Iron can be held inside cells instead of reaching the circulation.\norganism: Tissue-culture ferroportin systems\ntissue_or_cell_type: Plasma membrane\nexperimental_model: Hepcidin binding and cellular export experiments\nlimitations: Post-translational export regulation; no dose-response to dietary iron is inferred from the cell experiment.\nexposure: Hepcidin exposure\nevidence_span: {\"source_cache\": \"artifacts/iron-research/15514116.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"00a292f6693116798182b0f9418f2eb8466aa029f32905019416422002158c4a\", \"start_char\": 0, \"end_char\": 758, \"text_sha256\": \"00a292f6693116798182b0f9418f2eb8466aa029f32905019416422002158c4a\"}\n[iron-p15514116] Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. (2004). https://pubmed.ncbi.nlm.nih.gov/15514116/ DOI: 10.1126/science.1104742","model_system":"Hepcidin binding and cellular export experiments","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [iron-p15514116] Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. (2004). https://pubmed.ncbi.nlm.nih.gov/15514116/ DOI: 10.1126/science.1104742","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1560864c-91d1-58dc-90c4-49bf61aba3de","stable_key":"import-e13b03e1-a614-543a-ac1b-97df18cfe30d","title":"Iron: absorption, trafficking, iron-dependent enzymes and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"f9dab767a21c9bbfef3227707fe3c82953536bb1335599dd4ef93b5ea2dbf03f","revision_id":"77700d7f-2902-54b9-adae-8cbc77b24682","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}