Component
Cell adhesion and intracellular mechanical tension
Cell adhesion and intracellular mechanical tension. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Slc4a11 silencing abolished the boron-associated enhancement of adhesion and tension in C2C12 cells; replacing fibronectin with laminin-111 also abolished the response.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/boron-research/40270477.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e55fb244b3c6f4adc9c4b1ab4ed2e8bb2a866b01bc9b50b16ed85e1f4737aeab", "start_char": 0, "end_char": 997, "text_sha256": "e55fb244b3c6f4adc9c4b1ab4ed2e8bb2a866b01bc9b50b16ed85e1f4737aeab"}
- experimental_model
- Substrate-stiffness experiments, traction measurements and Slc4a11 silencing
- exposure
- Soluble boron supplied as borax; reported experimental concentrations 0.59 and 1.47 mM; variable substrate stiffness
- limitations
- Protein-dependence of a cell-mechanics phenotype does not demonstrate transmembrane borate transport. The authors use the historical transporter label; human transport remains disputed. Matrix coating and exposure are essential context.
- nutrient_topic
- Boron research collection; topical membership is not evidence of a direct dietary effect. · Boron
- organism
- Mouse C2C12 myoblasts
- plain_language
- Both the protein and the cells’ attachment surface mattered.
- primary_references
- [boron-p40270477] NaBC1 Boron Transporter Enables Myoblast Response to Substrate Rigidity via Fibronectin-Binding Integrins. (2025). https://pubmed.ncbi.nlm.nih.gov/40270477/ DOI: 10.1002/advs.202407548
- tissue_or_cell_type
- Cells on fibronectin-functionalized polyacrylamide hydrogels
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Boron: chemistry, nutrient interactions, low-intake studies and mechanistic uncertainties (2026-09-17) · lines 586–597
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Substrate-stiffness experiments, traction measurements and Slc4a11 silencing · source_derived_draft · unverified_draft
### boron-myoblast-slc4a11-dependence Slc4a11 silencing abolished the boron-associated enhancement of adhesion and tension in C2C12 cells; replacing fibronectin with laminin-111 also abolished the response. Condition category: machinery_impairment nutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect. plain_language: Both the protein and the cells’ attachment surface mattered. organism: Mouse C2C12 myoblasts tissue_or_cell_type: Cells on fibronectin-functionalized polyacrylamide hydrogels experimental_model: Substrate-stiffness experiments, traction measurements and Slc4a11 silencing limitations: Protein-dependence of a cell-mechanics phenotype does not demonstrate transmembrane borate transport. The authors use the historical transporter label; human transport remains disputed. Matrix coating and exposure are essential context. exposure: Soluble boron supplied as borax; reported experimental concentrations 0.59 and 1.47 mM; variable substrate stiffness evidence_span: {"source_cache": "artifacts/boron-research/40270477.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e55fb244b3c6f4adc9c4b1ab4ed2e8bb2a866b01bc9b50b16ed85e1f4737aeab", "start_char": 0, "end_char": 997, "text_sha256": "e55fb244b3c6f4adc9c4b1ab4ed2e8bb2a866b01bc9b50b16ed85e1f4737aeab"} [boron-p40270477] NaBC1 Boron Transporter Enables Myoblast Response to Substrate Rigidity via Fibronectin-Binding Integrins. (2025). https://pubmed.ncbi.nlm.nih.gov/40270477/ DOI: 10.1002/advs.202407548
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.