Component
Human CD247 messenger RNA
Study-scoped entity; inspect species, exposure and experimental limitations on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Arginine removal shortened CD247 mRNA half-life without reducing its transcription rate.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- evidence_access
- Primary abstract
- experimental_model
- Jurkat T cells in arginine-free culture medium.
- limitations
- Cell-line result; primary T cells showed a different regulatory level in the later study.
- nutrient_topic
- L-Arginine collection; tissue, species, dose and formulation distinctions retained. · L-Arginine
- plain_language
- Low availability changed how long an immune-signaling message survived.
- primary_references
- Regulation of T cell receptor CD3zeta chain expression by L-arginine. · 2002 · https://pubmed.ncbi.nlm.nih.gov/11950832/ · DOI 10.1074/jbc.m110675200
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
L-Arginine: transport, metabolic branches, nutrient interactions, availability and discovery questions (2026-09-18) · lines 270–276
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Jurkat T cells in arginine-free culture medium. · source_derived_draft · unverified_draft
## arg-jurkat-rna Low availability changed how long an immune-signaling message survived. Arginine removal shortened CD247 mRNA half-life without reducing its transcription rate. Model: Jurkat T cells in arginine-free culture medium. Limitations: Cell-line result; primary T cells showed a different regulatory level in the later study. Evidence access: Primary abstract Regulation of T cell receptor CD3zeta chain expression by L-arginine. · 2002 · https://pubmed.ncbi.nlm.nih.gov/11950832/ · DOI 10.1074/jbc.m110675200
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.