Component
CB1 receptor desensitisation
CB1 receptor desensitisation. Species, exposure and limitations are retained in each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Rapid CB1 receptor desensitisation defines the time course of ERK1/2 MAP kinase signalling.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/thc-research/17681354.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dda88f2600ad5892232cf931091df54c5fc62b303062f725df663d65778c4821", "start_char": 0, "end_char": 1915, "text_sha256": "dda88f2600ad5892232cf931091df54c5fc62b303062f725df663d65778c4821"}
- experimental_model
- Time-course measurement of CB1 desensitisation against ERK signalling
- exposure
- Agonist exposure with kinase and receptor measurement
- limitations
- Ties the adaptation timescale to a downstream kinase, which is what makes desensitisation measurable as a signalling change rather than only as binding.
- nutrient_topic
- THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
- organism
- Cultured cells
- plain_language
- How fast the receptor goes deaf sets how long the downstream signal lasts.
- primary_references
- [thc-p17681354] Rapid CB1 cannabinoid receptor desensitization defines the time course of ERK1/2 MAP kinase signaling. (2008). https://pubmed.ncbi.nlm.nih.gov/17681354/ DOI: 10.1016/j.neuropharm.2007.06.005
- tissue_or_cell_type
- Transfected cells
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 218–229
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Time-course measurement of CB1 desensitisation against ERK signalling · source_derived_draft · unverified_draft
### thc-desensitisation-erk Rapid CB1 receptor desensitisation defines the time course of ERK1/2 MAP kinase signalling. Condition category: machinery_impairment nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: How fast the receptor goes deaf sets how long the downstream signal lasts. organism: Cultured cells tissue_or_cell_type: Transfected cells experimental_model: Time-course measurement of CB1 desensitisation against ERK signalling limitations: Ties the adaptation timescale to a downstream kinase, which is what makes desensitisation measurable as a signalling change rather than only as binding. exposure: Agonist exposure with kinase and receptor measurement evidence_span: {"source_cache": "artifacts/thc-research/17681354.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dda88f2600ad5892232cf931091df54c5fc62b303062f725df663d65778c4821", "start_char": 0, "end_char": 1915, "text_sha256": "dda88f2600ad5892232cf931091df54c5fc62b303062f725df663d65778c4821"} [thc-p17681354] Rapid CB1 cannabinoid receptor desensitization defines the time course of ERK1/2 MAP kinase signaling. (2008). https://pubmed.ncbi.nlm.nih.gov/17681354/ DOI: 10.1016/j.neuropharm.2007.06.005
Complete structured claim and evidence
What acts on it
Distinct domains of the CB1 receptor mediate desensitisation and internalisation, so the two adaptive responses are separable.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/thc-research/10234009.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "73965589817407e173255ab6db300e7969b0e91a4ca4cd3d39cee1f5873d1e05", "start_char": 0, "end_char": 1911, "text_sha256": "73965589817407e173255ab6db300e7969b0e91a4ca4cd3d39cee1f5873d1e05"}
- experimental_model
- Mutational mapping of CB1 receptor domains against desensitisation and internalisation
- exposure
- Sustained agonist exposure with receptor trafficking measurement
- limitations
- Separates two adaptive processes that are often conflated. It is a recombinant system.
- nutrient_topic
- THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
- organism
- Recombinant receptor
- plain_language
- Going deaf to the drug and removing the receptor from the surface are two different things.
- primary_references
- [thc-p10234009] Distinct domains of the CB1 cannabinoid receptor mediate desensitization and internalization. (1999). https://pubmed.ncbi.nlm.nih.gov/10234009/ DOI: 10.1523/jneurosci.19-10-03773.1999
- tissue_or_cell_type
- Transfected cells
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 205–216
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mutational mapping of CB1 receptor domains against desensitisation and internalisation · source_derived_draft · unverified_draft
### thc-desensitisation-domains Distinct domains of the CB1 receptor mediate desensitisation and internalisation, so the two adaptive responses are separable. Condition category: machinery_impairment nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: Going deaf to the drug and removing the receptor from the surface are two different things. organism: Recombinant receptor tissue_or_cell_type: Transfected cells experimental_model: Mutational mapping of CB1 receptor domains against desensitisation and internalisation limitations: Separates two adaptive processes that are often conflated. It is a recombinant system. exposure: Sustained agonist exposure with receptor trafficking measurement evidence_span: {"source_cache": "artifacts/thc-research/10234009.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "73965589817407e173255ab6db300e7969b0e91a4ca4cd3d39cee1f5873d1e05", "start_char": 0, "end_char": 1911, "text_sha256": "73965589817407e173255ab6db300e7969b0e91a4ca4cd3d39cee1f5873d1e05"} [thc-p10234009] Distinct domains of the CB1 cannabinoid receptor mediate desensitization and internalization. (1999). https://pubmed.ncbi.nlm.nih.gov/10234009/ DOI: 10.1523/jneurosci.19-10-03773.1999
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.