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It is a recombinant system.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates.","comparator":null,"unit":null,"notes":"","entity":{"slug":"tetrahydrocannabinol","display_name":"Delta-9-tetrahydrocannabinol / THC","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Recombinant receptor","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Going deaf to the drug and removing the receptor from the surface are two different things.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[thc-p10234009] Distinct domains of the CB1 cannabinoid receptor mediate desensitization and internalization. (1999). https://pubmed.ncbi.nlm.nih.gov/10234009/ DOI: 10.1523/jneurosci.19-10-03773.1999","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Transfected cells","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"c6be7670-d584-574f-887c-50e3ca2cef3b","evidence_kind":"source_excerpt","locator":"Lines 205-216","start_line":205,"end_line":216,"excerpt":"### thc-desensitisation-domains\nDistinct domains of the CB1 receptor mediate desensitisation and internalisation, so the two adaptive responses are separable.\nCondition category: machinery_impairment\nnutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates.\nplain_language: Going deaf to the drug and removing the receptor from the surface are two different things.\norganism: Recombinant receptor\ntissue_or_cell_type: Transfected cells\nexperimental_model: Mutational mapping of CB1 receptor domains against desensitisation and internalisation\nlimitations: Separates two adaptive processes that are often conflated. It is a recombinant system.\nexposure: Sustained agonist exposure with receptor trafficking measurement\nevidence_span: {\"source_cache\": \"artifacts/thc-research/10234009.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"73965589817407e173255ab6db300e7969b0e91a4ca4cd3d39cee1f5873d1e05\", \"start_char\": 0, \"end_char\": 1911, \"text_sha256\": \"73965589817407e173255ab6db300e7969b0e91a4ca4cd3d39cee1f5873d1e05\"}\n[thc-p10234009] Distinct domains of the CB1 cannabinoid receptor mediate desensitization and internalization. (1999). https://pubmed.ncbi.nlm.nih.gov/10234009/ DOI: 10.1523/jneurosci.19-10-03773.1999","model_system":"Mutational mapping of CB1 receptor domains against desensitisation and internalisation","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [thc-p10234009] Distinct domains of the CB1 cannabinoid receptor mediate desensitization and internalization. (1999). https://pubmed.ncbi.nlm.nih.gov/10234009/ DOI: 10.1523/jneurosci.19-10-03773.1999","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b4367320-9724-507a-bead-6932fa0a78cb","stable_key":"import-05a3cf47-e660-5ab3-8c32-5eba9847cf0a","title":"THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"60abc81737d18b7a50b01ca487e38291774ee15d9777651aa2d3eac8670ac3b2","revision_id":"2cba3552-af89-580d-b20a-8cfb1b14f9e7","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}