Component
Human CaSR R62A construct
Human CaSR R62A construct. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
The R62A CaSR construct lost the phosphate-induced receptor inhibition observed with wild-type receptor.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/phosphorus-research/31619668.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e4fe1ed7eb92175f99f446afa19fb184147ceed0413f3a6dffa85aa80927015d", "start_char": 0, "end_char": 1144, "text_sha256": "e4fe1ed7eb92175f99f446afa19fb184147ceed0413f3a6dffa85aa80927015d"}
- experimental_model
- CaSR expression/mutagenesis and isolated human/mouse parathyroid experiments
- exposure
- Extracellular phosphate in pathophysiologic CKD ranges; R62A substitution and mouse Casr deletion
- limitations
- R62A identity resolved in full text; not a common variant or a dietary model.
- nutrient_topic
- Phosphorus research collection; topical membership is not evidence of a direct dietary effect. · Phosphorus
- organism
- Human CaSR construct
- plain_language
- Altering a specific receptor site removed the phosphate response.
- primary_references
- [phosphorus-p31619668] Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion. (2019). https://pubmed.ncbi.nlm.nih.gov/31619668/ DOI: 10.1038/s41467-019-12399-9
- tissue_or_cell_type
- CaSR reporter cells and freshly isolated parathyroid cells/glands
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Phosphorus: metabolism, signaling and nutrient connections (2026-09-17) · lines 464–475
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · CaSR expression/mutagenesis and isolated human/mouse parathyroid experiments · source_derived_draft · unverified_draft
### phosphorus-casr-r62 The R62A CaSR construct lost the phosphate-induced receptor inhibition observed with wild-type receptor. Condition category: machinery_impairment nutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect. plain_language: Altering a specific receptor site removed the phosphate response. organism: Human CaSR construct tissue_or_cell_type: CaSR reporter cells and freshly isolated parathyroid cells/glands experimental_model: CaSR expression/mutagenesis and isolated human/mouse parathyroid experiments limitations: R62A identity resolved in full text; not a common variant or a dietary model. exposure: Extracellular phosphate in pathophysiologic CKD ranges; R62A substitution and mouse Casr deletion evidence_span: {"source_cache": "artifacts/phosphorus-research/31619668.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e4fe1ed7eb92175f99f446afa19fb184147ceed0413f3a6dffa85aa80927015d", "start_char": 0, "end_char": 1144, "text_sha256": "e4fe1ed7eb92175f99f446afa19fb184147ceed0413f3a6dffa85aa80927015d"} [phosphorus-p31619668] Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion. (2019). https://pubmed.ncbi.nlm.nih.gov/31619668/ DOI: 10.1038/s41467-019-12399-9
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.