Component
Glucuronide conjugates of capsaicin and dihydrocapsaicin
Glucuronide conjugates of capsaicin and dihydrocapsaicin. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The structure of the glucuronide metabolites of capsaicin and dihydrocapsaicin that appeared in the perfusate during 90 minutes of luminal perfusion of a standardised Capsicum extract was identified by mass spectrometry.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/dihydrocapsaicin-research/25462121.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "667a4d33ee4b6423efe4532d0138ba6eb68a08fcc41b33ff5d04f442ad6f6177", "start_char": 0, "end_char": 1576, "text_sha256": "667a4d33ee4b6423efe4532d0138ba6eb68a08fcc41b33ff5d04f442ad6f6177"}
- experimental_model
- Validated reverse-phase HPLC with fluorescence detection applied to rat small intestine luminal perfusion
- exposure
- Standardised Capsicum extract at 30 micrograms per millilitre perfused luminally for 90 minutes
- limitations
- Primarily a method development paper. The substantive finding recorded here is the identification of glucuronide conjugates of both compounds in the perfusate by mass spectrometry.
- nutrient_topic
- Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. · Dihydrocapsaicin
- organism
- Rat
- plain_language
- The gut also attaches a sugar group to both compounds while they are being absorbed.
- primary_references
- [dhc-p25462121] A validated HPLC-FLD method for analysis of intestinal absorption and metabolism of capsaicin and dihydrocapsaicin in the rat. (2015). https://pubmed.ncbi.nlm.nih.gov/25462121/ DOI: 10.1016/j.jpba.2014.10.007
- tissue_or_cell_type
- Small intestine lumen
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Validated reverse-phase HPLC with fluorescence detection applied to rat small intestine luminal perfusion · source_derived_draft · unverified_draft
### dhc-glucuronidation-in-gut The structure of the glucuronide metabolites of capsaicin and dihydrocapsaicin that appeared in the perfusate during 90 minutes of luminal perfusion of a standardised Capsicum extract was identified by mass spectrometry. Condition category: normal nutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. plain_language: The gut also attaches a sugar group to both compounds while they are being absorbed. organism: Rat tissue_or_cell_type: Small intestine lumen experimental_model: Validated reverse-phase HPLC with fluorescence detection applied to rat small intestine luminal perfusion limitations: Primarily a method development paper. The substantive finding recorded here is the identification of glucuronide conjugates of both compounds in the perfusate by mass spectrometry. exposure: Standardised Capsicum extract at 30 micrograms per millilitre perfused luminally for 90 minutes evidence_span: {"source_cache": "artifacts/dihydrocapsaicin-research/25462121.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "667a4d33ee4b6423efe4532d0138ba6eb68a08fcc41b33ff5d04f442ad6f6177", "start_char": 0, "end_char": 1576, "text_sha256": "667a4d33ee4b6423efe4532d0138ba6eb68a08fcc41b33ff5d04f442ad6f6177"} [dhc-p25462121] A validated HPLC-FLD method for analysis of intestinal absorption and metabolism of capsaicin and dihydrocapsaicin in the rat. (2015). https://pubmed.ncbi.nlm.nih.gov/25462121/ DOI: 10.1016/j.jpba.2014.10.007
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.