Component
Human carbonic anhydrase VI / CA6
Human secreted carbonic anhydrase VI purified from saliva or milk; not a CA2-based mimic.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Purified human salivary and milk CA6 catalyzed CO2 hydration, with reported kcat values of 3.3×10^5 and 2.3×10^5 s−1, respectively.
Experimental context and source evidence
- cross_nutrient
- false
- experimental_model
- Human CA6 purified from pooled saliva or breast milk; stopped-flow enzymology
- exposure
- Stopped-flow CO2 hydration assay of proteins purified from pooled human saliva and milk.
- limitations
- Protein kinetic measurements; no test of dietary zinc treatment or infant health outcomes. Table values characterize the isolated preparations.
- nutrient_topic
- Zinc research collection; topical membership is not evidence of a direct dietary effect. · Zinc
- organism
- Homo sapiens
- plain_language
- Secreted CA6 accelerates conversion of carbon dioxide and water into bicarbonate.
- primary_references
- [zinc-enz-ca6-2022] Biochemical and Biophysical Characterization of Carbonic Anhydrase VI from Human Milk and Saliva. (2022). https://pubmed.ncbi.nlm.nih.gov/35947329/ DOI: 10.1007/s10930-022-10070-9
- tissue_or_cell_type
- Human saliva and breast milk; purified enzyme assay
Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17) · lines 664–675
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human CA6 purified from pooled saliva or breast milk; stopped-flow enzymology · source_derived_draft · unverified_draft
### zinc-enz-ca6-hydration Purified human salivary and milk CA6 catalyzed CO2 hydration, with reported kcat values of 3.3×10^5 and 2.3×10^5 s−1, respectively. Condition category: normal nutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect. plain_language: Secreted CA6 accelerates conversion of carbon dioxide and water into bicarbonate. organism: Homo sapiens tissue_or_cell_type: Human saliva and breast milk; purified enzyme assay experimental_model: Human CA6 purified from pooled saliva or breast milk; stopped-flow enzymology limitations: Protein kinetic measurements; no test of dietary zinc treatment or infant health outcomes. Table values characterize the isolated preparations. exposure: Stopped-flow CO2 hydration assay of proteins purified from pooled human saliva and milk. cross_nutrient: false [zinc-enz-ca6-2022] Biochemical and Biophysical Characterization of Carbonic Anhydrase VI from Human Milk and Saliva. (2022). https://pubmed.ncbi.nlm.nih.gov/35947329/ DOI: 10.1007/s10930-022-10070-9
Complete structured claim and evidence
What acts on it
Acetazolamide inhibited salivary and milk human CA6 with reported Ki values of 16 and 23 nM in the enzyme assay.
Experimental context and source evidence
- cross_nutrient
- false
- experimental_model
- Human CA6 purified from pooled saliva or breast milk; stopped-flow enzymology
- exposure
- Inhibitor dilution series in stopped-flow enzymology; not oral treatment.
- limitations
- Assay inhibition does not measure nutrient deficiency or treatment efficacy.
- nutrient_topic
- Zinc research collection; topical membership is not evidence of a direct dietary effect. · Zinc
- organism
- Homo sapiens
- plain_language
- A carbonic anhydrase inhibitor blocked the purified secreted enzyme.
- primary_references
- [zinc-enz-ca6-2022] Biochemical and Biophysical Characterization of Carbonic Anhydrase VI from Human Milk and Saliva. (2022). https://pubmed.ncbi.nlm.nih.gov/35947329/ DOI: 10.1007/s10930-022-10070-9
- tissue_or_cell_type
- Purified human saliva and milk CA6
Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17) · lines 677–688
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human CA6 purified from pooled saliva or breast milk; stopped-flow enzymology · source_derived_draft · unverified_draft
### zinc-enz-ca6-inhibition Acetazolamide inhibited salivary and milk human CA6 with reported Ki values of 16 and 23 nM in the enzyme assay. Condition category: normal nutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect. plain_language: A carbonic anhydrase inhibitor blocked the purified secreted enzyme. organism: Homo sapiens tissue_or_cell_type: Purified human saliva and milk CA6 experimental_model: Human CA6 purified from pooled saliva or breast milk; stopped-flow enzymology limitations: Assay inhibition does not measure nutrient deficiency or treatment efficacy. exposure: Inhibitor dilution series in stopped-flow enzymology; not oral treatment. cross_nutrient: false [zinc-enz-ca6-2022] Biochemical and Biophysical Characterization of Carbonic Anhydrase VI from Human Milk and Saliva. (2022). https://pubmed.ncbi.nlm.nih.gov/35947329/ DOI: 10.1007/s10930-022-10070-9
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.