Component

Bacteroides thetaiotaomicron BT2157

Bacteroides thetaiotaomicron BT2157. Species, exposure and limitations are retained in each linked claim.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. BT2157 supported glucosinolate activation when combined with BT2158 in vitro.

    Bacteroides thetaiotaomicron BT2157 → Glucosinolate-to-isothiocyanate conversion by B. thetaiotaomicron enzymes source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/sulforaphane-research/32084341.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "08eaa102da24fdee1f16fa9376338c557ba4f3919adb1122f3e13d509a171293", "start_char": 0, "end_char": 1031, "text_sha256": "08eaa102da24fdee1f16fa9376338c557ba4f3919adb1122f3e13d509a171293"}
    experimental_model
    Bacterial genetics, purified-enzyme reconstitution and gnotobiotic mice
    exposure
    BT2159-BT2156 transfer; individual enzyme combinations and BT2157 mutant
    limitations
    Microbial enzymes are distinct from plant myrosinase; general glucosinolate experiments do not prove every substrate follows identical kinetics.
    nutrient_topic
    Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. · Sulforaphane / SFN, stereochemistry specified per study
    organism
    B. thetaiotaomicron, engineered B. fragilis and monoassociated mice
    plain_language
    An alternative partner was active in the enzyme assay.
    primary_references
    [sulforaphane-p32084341] A Metabolic Pathway for Activation of Dietary Glucosinolates by a Human Gut Symbiont. (2020). https://pubmed.ncbi.nlm.nih.gov/32084341/ DOI: 10.1016/j.cell.2020.01.023
    tissue_or_cell_type
    Microbial glucosinolate activation

    Sulforaphane: formation, electrophile sensing and nutrient connections (2026-09-17) · lines 229–240

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Bacterial genetics, purified-enzyme reconstitution and gnotobiotic mice · source_derived_draft · unverified_draft

    ### sulforaphane-bt2157 BT2157 supported glucosinolate activation when combined with BT2158 in vitro. Condition category: normal nutrient_topic: Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. plain_language: An alternative partner was active in the enzyme assay. organism: B. thetaiotaomicron, engineered B. fragilis and monoassociated mice tissue_or_cell_type: Microbial glucosinolate activation experimental_model: Bacterial genetics, purified-enzyme reconstitution and gnotobiotic mice limitations: Microbial enzymes are distinct from plant myrosinase; general glucosinolate experiments do not prove every substrate follows identical kinetics. exposure: BT2159-BT2156 transfer; individual enzyme combinations and BT2157 mutant evidence_span: {"source_cache": "artifacts/sulforaphane-research/32084341.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "08eaa102da24fdee1f16fa9376338c557ba4f3919adb1122f3e13d509a171293", "start_char": 0, "end_char": 1031, "text_sha256": "08eaa102da24fdee1f16fa9376338c557ba4f3919adb1122f3e13d509a171293"} [sulforaphane-p32084341] A Metabolic Pathway for Activation of Dietary Glucosinolates by a Human Gut Symbiont. (2020). https://pubmed.ncbi.nlm.nih.gov/32084341/ DOI: 10.1016/j.cell.2020.01.023
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. BT2156 supported glucosinolate activation when combined with BT2158 in the biochemical reconstitution.

    Bacteroides thetaiotaomicron BT2156 → Glucosinolate-to-isothiocyanate conversion by B. thetaiotaomicron enzymes source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/sulforaphane-research/32084341.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "08eaa102da24fdee1f16fa9376338c557ba4f3919adb1122f3e13d509a171293", "start_char": 0, "end_char": 1031, "text_sha256": "08eaa102da24fdee1f16fa9376338c557ba4f3919adb1122f3e13d509a171293"}
    experimental_model
    Bacterial genetics, purified-enzyme reconstitution and gnotobiotic mice
    exposure
    BT2159-BT2156 transfer; individual enzyme combinations and BT2157 mutant
    limitations
    Microbial enzymes are distinct from plant myrosinase; general glucosinolate experiments do not prove every substrate follows identical kinetics.
    nutrient_topic
    Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. · Sulforaphane / SFN, stereochemistry specified per study
    organism
    B. thetaiotaomicron, engineered B. fragilis and monoassociated mice
    plain_language
    One partner can support this conversion.
    primary_references
    [sulforaphane-p32084341] A Metabolic Pathway for Activation of Dietary Glucosinolates by a Human Gut Symbiont. (2020). https://pubmed.ncbi.nlm.nih.gov/32084341/ DOI: 10.1016/j.cell.2020.01.023
    tissue_or_cell_type
    Microbial glucosinolate activation

    Sulforaphane: formation, electrophile sensing and nutrient connections (2026-09-17) · lines 216–227

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Bacterial genetics, purified-enzyme reconstitution and gnotobiotic mice · source_derived_draft · unverified_draft

    ### sulforaphane-bt2156 BT2156 supported glucosinolate activation when combined with BT2158 in the biochemical reconstitution. Condition category: normal nutrient_topic: Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. plain_language: One partner can support this conversion. organism: B. thetaiotaomicron, engineered B. fragilis and monoassociated mice tissue_or_cell_type: Microbial glucosinolate activation experimental_model: Bacterial genetics, purified-enzyme reconstitution and gnotobiotic mice limitations: Microbial enzymes are distinct from plant myrosinase; general glucosinolate experiments do not prove every substrate follows identical kinetics. exposure: BT2159-BT2156 transfer; individual enzyme combinations and BT2157 mutant evidence_span: {"source_cache": "artifacts/sulforaphane-research/32084341.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "08eaa102da24fdee1f16fa9376338c557ba4f3919adb1122f3e13d509a171293", "start_char": 0, "end_char": 1031, "text_sha256": "08eaa102da24fdee1f16fa9376338c557ba4f3919adb1122f3e13d509a171293"} [sulforaphane-p32084341] A Metabolic Pathway for Activation of Dietary Glucosinolates by a Human Gut Symbiont. (2020). https://pubmed.ncbi.nlm.nih.gov/32084341/ DOI: 10.1016/j.cell.2020.01.023
    Complete structured claim and evidence

  2. In vitro isothiocyanate formation required BT2158 together with either BT2156 or BT2157.

    Bacteroides thetaiotaomicron BT2158 → Glucosinolate-to-isothiocyanate conversion by B. thetaiotaomicron enzymes source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/sulforaphane-research/32084341.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "08eaa102da24fdee1f16fa9376338c557ba4f3919adb1122f3e13d509a171293", "start_char": 0, "end_char": 1031, "text_sha256": "08eaa102da24fdee1f16fa9376338c557ba4f3919adb1122f3e13d509a171293"}
    experimental_model
    Bacterial genetics, purified-enzyme reconstitution and gnotobiotic mice
    exposure
    BT2159-BT2156 transfer; individual enzyme combinations and BT2157 mutant
    limitations
    Microbial enzymes are distinct from plant myrosinase; general glucosinolate experiments do not prove every substrate follows identical kinetics.
    nutrient_topic
    Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. · Sulforaphane / SFN, stereochemistry specified per study
    organism
    B. thetaiotaomicron, engineered B. fragilis and monoassociated mice
    plain_language
    The bacterial route uses cooperating proteins.
    primary_references
    [sulforaphane-p32084341] A Metabolic Pathway for Activation of Dietary Glucosinolates by a Human Gut Symbiont. (2020). https://pubmed.ncbi.nlm.nih.gov/32084341/ DOI: 10.1016/j.cell.2020.01.023
    tissue_or_cell_type
    Microbial glucosinolate activation

    Sulforaphane: formation, electrophile sensing and nutrient connections (2026-09-17) · lines 203–214

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Bacterial genetics, purified-enzyme reconstitution and gnotobiotic mice · source_derived_draft · unverified_draft

    ### sulforaphane-bt2158 In vitro isothiocyanate formation required BT2158 together with either BT2156 or BT2157. Condition category: normal nutrient_topic: Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. plain_language: The bacterial route uses cooperating proteins. organism: B. thetaiotaomicron, engineered B. fragilis and monoassociated mice tissue_or_cell_type: Microbial glucosinolate activation experimental_model: Bacterial genetics, purified-enzyme reconstitution and gnotobiotic mice limitations: Microbial enzymes are distinct from plant myrosinase; general glucosinolate experiments do not prove every substrate follows identical kinetics. exposure: BT2159-BT2156 transfer; individual enzyme combinations and BT2157 mutant evidence_span: {"source_cache": "artifacts/sulforaphane-research/32084341.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "08eaa102da24fdee1f16fa9376338c557ba4f3919adb1122f3e13d509a171293", "start_char": 0, "end_char": 1031, "text_sha256": "08eaa102da24fdee1f16fa9376338c557ba4f3919adb1122f3e13d509a171293"} [sulforaphane-p32084341] A Metabolic Pathway for Activation of Dietary Glucosinolates by a Human Gut Symbiont. (2020). https://pubmed.ncbi.nlm.nih.gov/32084341/ DOI: 10.1016/j.cell.2020.01.023
    Complete structured claim and evidence

  3. Mice monoassociated with the BT2157-mutant strain had lower gastrointestinal isothiocyanate production.

    B. thetaiotaomicron BT2157 loss in a monoassociated mouse experiment → Glucosinolate-to-isothiocyanate conversion by B. thetaiotaomicron enzymes source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/sulforaphane-research/32084341.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "08eaa102da24fdee1f16fa9376338c557ba4f3919adb1122f3e13d509a171293", "start_char": 0, "end_char": 1031, "text_sha256": "08eaa102da24fdee1f16fa9376338c557ba4f3919adb1122f3e13d509a171293"}
    experimental_model
    Bacterial genetics, purified-enzyme reconstitution and gnotobiotic mice
    exposure
    BT2159-BT2156 transfer; individual enzyme combinations and BT2157 mutant
    limitations
    Microbial enzymes are distinct from plant myrosinase; general glucosinolate experiments do not prove every substrate follows identical kinetics.
    nutrient_topic
    Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. · Sulforaphane / SFN, stereochemistry specified per study
    organism
    B. thetaiotaomicron, engineered B. fragilis and monoassociated mice
    plain_language
    Losing microbial conversion capacity can reduce activation of the precursor.
    primary_references
    [sulforaphane-p32084341] A Metabolic Pathway for Activation of Dietary Glucosinolates by a Human Gut Symbiont. (2020). https://pubmed.ncbi.nlm.nih.gov/32084341/ DOI: 10.1016/j.cell.2020.01.023
    tissue_or_cell_type
    Microbial glucosinolate activation
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Sulforaphane: formation, electrophile sensing and nutrient connections (2026-09-17) · lines 242–253

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Bacterial genetics, purified-enzyme reconstitution and gnotobiotic mice · source_derived_draft · unverified_draft

    ### sulforaphane-microbial-loss Mice monoassociated with the BT2157-mutant strain had lower gastrointestinal isothiocyanate production. Condition category: machinery_impairment nutrient_topic: Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. plain_language: Losing microbial conversion capacity can reduce activation of the precursor. organism: B. thetaiotaomicron, engineered B. fragilis and monoassociated mice tissue_or_cell_type: Microbial glucosinolate activation experimental_model: Bacterial genetics, purified-enzyme reconstitution and gnotobiotic mice limitations: Microbial enzymes are distinct from plant myrosinase; general glucosinolate experiments do not prove every substrate follows identical kinetics. exposure: BT2159-BT2156 transfer; individual enzyme combinations and BT2157 mutant evidence_span: {"source_cache": "artifacts/sulforaphane-research/32084341.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "08eaa102da24fdee1f16fa9376338c557ba4f3919adb1122f3e13d509a171293", "start_char": 0, "end_char": 1031, "text_sha256": "08eaa102da24fdee1f16fa9376338c557ba4f3919adb1122f3e13d509a171293"} [sulforaphane-p32084341] A Metabolic Pathway for Activation of Dietary Glucosinolates by a Human Gut Symbiont. (2020). https://pubmed.ncbi.nlm.nih.gov/32084341/ DOI: 10.1016/j.cell.2020.01.023
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards