Component
B. thetaiotaomicron BT2157 loss in a monoassociated mouse experiment
B. thetaiotaomicron BT2157 loss in a monoassociated mouse experiment. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Mice monoassociated with the BT2157-mutant strain had lower gastrointestinal isothiocyanate production.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/sulforaphane-research/32084341.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "08eaa102da24fdee1f16fa9376338c557ba4f3919adb1122f3e13d509a171293", "start_char": 0, "end_char": 1031, "text_sha256": "08eaa102da24fdee1f16fa9376338c557ba4f3919adb1122f3e13d509a171293"}
- experimental_model
- Bacterial genetics, purified-enzyme reconstitution and gnotobiotic mice
- exposure
- BT2159-BT2156 transfer; individual enzyme combinations and BT2157 mutant
- limitations
- Microbial enzymes are distinct from plant myrosinase; general glucosinolate experiments do not prove every substrate follows identical kinetics.
- nutrient_topic
- Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. · Sulforaphane / SFN, stereochemistry specified per study
- organism
- B. thetaiotaomicron, engineered B. fragilis and monoassociated mice
- plain_language
- Losing microbial conversion capacity can reduce activation of the precursor.
- primary_references
- [sulforaphane-p32084341] A Metabolic Pathway for Activation of Dietary Glucosinolates by a Human Gut Symbiont. (2020). https://pubmed.ncbi.nlm.nih.gov/32084341/ DOI: 10.1016/j.cell.2020.01.023
- tissue_or_cell_type
- Microbial glucosinolate activation
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Sulforaphane: formation, electrophile sensing and nutrient connections (2026-09-17) · lines 242–253
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Bacterial genetics, purified-enzyme reconstitution and gnotobiotic mice · source_derived_draft · unverified_draft
### sulforaphane-microbial-loss Mice monoassociated with the BT2157-mutant strain had lower gastrointestinal isothiocyanate production. Condition category: machinery_impairment nutrient_topic: Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. plain_language: Losing microbial conversion capacity can reduce activation of the precursor. organism: B. thetaiotaomicron, engineered B. fragilis and monoassociated mice tissue_or_cell_type: Microbial glucosinolate activation experimental_model: Bacterial genetics, purified-enzyme reconstitution and gnotobiotic mice limitations: Microbial enzymes are distinct from plant myrosinase; general glucosinolate experiments do not prove every substrate follows identical kinetics. exposure: BT2159-BT2156 transfer; individual enzyme combinations and BT2157 mutant evidence_span: {"source_cache": "artifacts/sulforaphane-research/32084341.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "08eaa102da24fdee1f16fa9376338c557ba4f3919adb1122f3e13d509a171293", "start_char": 0, "end_char": 1031, "text_sha256": "08eaa102da24fdee1f16fa9376338c557ba4f3919adb1122f3e13d509a171293"} [sulforaphane-p32084341] A Metabolic Pathway for Activation of Dietary Glucosinolates by a Human Gut Symbiont. (2020). https://pubmed.ncbi.nlm.nih.gov/32084341/ DOI: 10.1016/j.cell.2020.01.023
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.