Component
Brugia malayi microfilarial viability in culture
Direct parasite survival in culture, separate from clearance in a host.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Ivermectin had little direct effect on Brugia malayi microfilariae in culture at pharmacologically relevant concentrations.
Experimental context and source evidence
- duration
- Not stated here
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- experimental_model
- Brugia malayi microfilariae in culture
- exposure
- Pharmacologically relevant ivermectin concentrations
- limitations
- A null result in culture does not exclude killing in the host, where immune clearance is available; it is the reason the secretion mechanism was investigated.
- organism
- Brugia malayi microfilariae in culture
- plain_language
- Ivermectin had little direct effect on Brugia malayi microfilariae in culture at pharmacologically relevant concentrations.
- primary_references
- Ivermectin disrupts the function of the excretory-secretory apparatus in microfilariae of Brugia malayi. (2010). https://pubmed.ncbi.nlm.nih.gov/21041637/ DOI: 10.1073/pnas.1011983107
- route
- In vitro
- tissue
- Parasite viability
Ivermectin: mechanism of action across parasite, host barrier and mammalian targets (2026-09-22) · lines 46–55
Original AI-assisted curation of sixteen primary studies resolved by PubMed title search and cross-checked against live PubMed metadata. Study-specific citations, concentrations, negative findings and limitations retained. Not publisher full text. · supports · · source_derived_draft · unverified_draft
## ivermectin-microfilaria-direct-kill-null Ivermectin had little direct effect on Brugia malayi microfilariae in culture at pharmacologically relevant concentrations. Model/species: Brugia malayi microfilariae in culture Tissue/system: Parasite viability Exposure: Pharmacologically relevant ivermectin concentrations Route: In vitro Duration: Not stated here Limits: A null result in culture does not exclude killing in the host, where immune clearance is available; it is the reason the secretion mechanism was investigated. Primary reference: Ivermectin disrupts the function of the excretory-secretory apparatus in microfilariae of Brugia malayi. (2010). https://pubmed.ncbi.nlm.nih.gov/21041637/ DOI: 10.1073/pnas.1011983107 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.